CDCA3

 

Full name: cell division cycle associated 3 Alias Symbol: TOME-1|GRCC8
Type: protein-coding gene Cytoband: 12p13.31
Entrez ID: 83461 HGNC ID: HGNC:14624 Ensembl Gene: ENSG00000111665 OMIM ID: 607749
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of CDCA3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDCA3 83461 223307_at 1.3262 0.0331
GSE20347 CDCA3 83461 221436_s_at 1.1268 0.0000
GSE23400 CDCA3 83461 221436_s_at 0.4153 0.0000
GSE26886 CDCA3 83461 223307_at 1.0910 0.0113
GSE29001 CDCA3 83461 221436_s_at 0.8879 0.0006
GSE38129 CDCA3 83461 221436_s_at 1.3265 0.0000
GSE45670 CDCA3 83461 223307_at 1.4125 0.0000
GSE53622 CDCA3 83461 42497 2.0130 0.0000
GSE53624 CDCA3 83461 42497 2.0095 0.0000
GSE63941 CDCA3 83461 223307_at 2.3143 0.0089
GSE77861 CDCA3 83461 223307_at 0.7837 0.0018
GSE97050 CDCA3 83461 A_24_P218979 0.9551 0.1113
SRP007169 CDCA3 83461 RNAseq 2.4464 0.0000
SRP008496 CDCA3 83461 RNAseq 1.8861 0.0000
SRP064894 CDCA3 83461 RNAseq 1.7594 0.0000
SRP133303 CDCA3 83461 RNAseq 1.6010 0.0000
SRP159526 CDCA3 83461 RNAseq 1.6431 0.0000
SRP193095 CDCA3 83461 RNAseq 0.9429 0.0000
SRP219564 CDCA3 83461 RNAseq 1.3697 0.0183
TCGA CDCA3 83461 RNAseq 1.1609 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by CDCA3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDCA3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDCA3 83461 9 3 18
GSE20123 CDCA3 83461 9 3 18
GSE43470 CDCA3 83461 8 3 32
GSE46452 CDCA3 83461 10 1 48
GSE47630 CDCA3 83461 12 2 26
GSE54993 CDCA3 83461 1 10 59
GSE54994 CDCA3 83461 10 2 41
GSE60625 CDCA3 83461 0 1 10
GSE74703 CDCA3 83461 7 2 27
GSE74704 CDCA3 83461 5 3 12
TCGA CDCA3 83461 40 6 50

Total number of gains: 111; Total number of losses: 36; Total Number of normals: 341.  

 

Somatic mutations of CDCA3:

 

Generating mutation plots.

 

Highly correlated genes for CDCA3:

 

Showing top 20/2175 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDCA3FOXM10.86654712012
CDCA3NCAPH0.852824909
CDCA3BUB10.85158811011
CDCA3CCNB20.84625112012
CDCA3UBE2C0.84356613013
CDCA3CEP550.82877813013
CDCA3TPX20.82822913013
CDCA3SPAG50.8272613013
CDCA3MTFR20.824861707
CDCA3KNSTRN0.823196707
CDCA3MCM20.82219412012
CDCA3NEK20.82140613013
CDCA3RAD51AP10.82010613012
CDCA3NCAPD20.82006313013
CDCA3KIF20A0.81871513013
CDCA3ATAD20.81837413013
CDCA3NUF20.813568908
CDCA3AURKB0.81209713013
CDCA3BIRC50.80973912012
CDCA3UBE2T0.809322909

For details and further investigation, click here