| Full name: cytochrome b-245 alpha chain | Alias Symbol: p22-PHOX | ||
| Type: protein-coding gene | Cytoband: 16q24.2 | ||
| Entrez ID: 1535 | HGNC ID: HGNC:2577 | Ensembl Gene: ENSG00000051523 | OMIM ID: 608508 |
| Drug and gene relationship at DGIdb | |||
CYBA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa04670 | Leukocyte transendothelial migration | |
| hsa05140 | Leishmaniasis |
Expression of CYBA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYBA | 1535 | 203028_s_at | 0.6613 | 0.3032 | |
| GSE20347 | CYBA | 1535 | 203028_s_at | 0.4610 | 0.0235 | |
| GSE23400 | CYBA | 1535 | 203028_s_at | 0.5498 | 0.0000 | |
| GSE26886 | CYBA | 1535 | 203028_s_at | 0.3853 | 0.2806 | |
| GSE29001 | CYBA | 1535 | 203028_s_at | 0.6159 | 0.0842 | |
| GSE38129 | CYBA | 1535 | 203028_s_at | 0.8411 | 0.0002 | |
| GSE45670 | CYBA | 1535 | 203028_s_at | 0.4569 | 0.0622 | |
| GSE53622 | CYBA | 1535 | 41275 | 0.7461 | 0.0000 | |
| GSE53624 | CYBA | 1535 | 41275 | 0.8486 | 0.0000 | |
| GSE63941 | CYBA | 1535 | 203028_s_at | 0.8398 | 0.4853 | |
| GSE77861 | CYBA | 1535 | 203028_s_at | 0.1405 | 0.7320 | |
| GSE97050 | CYBA | 1535 | A_33_P3372332 | 1.2604 | 0.0888 | |
| SRP007169 | CYBA | 1535 | RNAseq | 0.8472 | 0.0872 | |
| SRP008496 | CYBA | 1535 | RNAseq | 0.4832 | 0.1451 | |
| SRP064894 | CYBA | 1535 | RNAseq | 1.8196 | 0.0000 | |
| SRP133303 | CYBA | 1535 | RNAseq | 0.8666 | 0.0054 | |
| SRP159526 | CYBA | 1535 | RNAseq | 0.6390 | 0.1080 | |
| SRP193095 | CYBA | 1535 | RNAseq | 0.2674 | 0.2984 | |
| SRP219564 | CYBA | 1535 | RNAseq | 1.3383 | 0.0012 | |
| TCGA | CYBA | 1535 | RNAseq | 0.2226 | 0.0074 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CYBA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYBA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYBA | 1535 | 4 | 3 | 23 | |
| GSE20123 | CYBA | 1535 | 4 | 3 | 23 | |
| GSE43470 | CYBA | 1535 | 1 | 13 | 29 | |
| GSE46452 | CYBA | 1535 | 38 | 1 | 20 | |
| GSE47630 | CYBA | 1535 | 11 | 9 | 20 | |
| GSE54993 | CYBA | 1535 | 3 | 4 | 63 | |
| GSE54994 | CYBA | 1535 | 9 | 11 | 33 | |
| GSE60625 | CYBA | 1535 | 4 | 0 | 7 | |
| GSE74703 | CYBA | 1535 | 1 | 9 | 26 | |
| GSE74704 | CYBA | 1535 | 3 | 2 | 15 | |
| TCGA | CYBA | 1535 | 28 | 15 | 53 |
Total number of gains: 106; Total number of losses: 70; Total Number of normals: 312.
Somatic mutations of CYBA:
Generating mutation plots.
Highly correlated genes for CYBA:
Showing top 20/950 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYBA | CERKL | 0.782797 | 3 | 0 | 3 |
| CYBA | PDIA5 | 0.773457 | 3 | 0 | 3 |
| CYBA | SUSD1 | 0.760779 | 4 | 0 | 4 |
| CYBA | KTI12 | 0.756175 | 3 | 0 | 3 |
| CYBA | ASF1A | 0.75299 | 3 | 0 | 3 |
| CYBA | FCGR3A | 0.749125 | 3 | 0 | 3 |
| CYBA | LRRC8C | 0.743326 | 3 | 0 | 3 |
| CYBA | SORD | 0.740614 | 3 | 0 | 3 |
| CYBA | BCCIP | 0.740425 | 3 | 0 | 3 |
| CYBA | IKBIP | 0.720094 | 4 | 0 | 4 |
| CYBA | TMEM200A | 0.715035 | 3 | 0 | 3 |
| CYBA | WDR54 | 0.711176 | 4 | 0 | 4 |
| CYBA | TNFAIP1 | 0.704986 | 3 | 0 | 3 |
| CYBA | ALG2 | 0.70429 | 4 | 0 | 4 |
| CYBA | TMEM186 | 0.703119 | 3 | 0 | 3 |
| CYBA | C19orf38 | 0.701992 | 3 | 0 | 3 |
| CYBA | ZFPL1 | 0.700384 | 3 | 0 | 3 |
| CYBA | SLC30A7 | 0.696937 | 4 | 0 | 3 |
| CYBA | GEMIN4 | 0.694934 | 3 | 0 | 3 |
| CYBA | GPR132 | 0.693344 | 4 | 0 | 4 |
For details and further investigation, click here
