ATAD3A

 

Full name: ATPase family AAA domain containing 3A Alias Symbol: FLJ10709
Type: protein-coding gene Cytoband: 1p36.33
Entrez ID: 55210 HGNC ID: HGNC:25567 Ensembl Gene: ENSG00000197785 OMIM ID: 612316
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ATAD3A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATAD3A 55210 227700_x_at 0.5579 0.1802
GSE26886 ATAD3A 55210 227700_x_at 0.5676 0.0000
GSE45670 ATAD3A 55210 227700_x_at 0.3445 0.0003
GSE53622 ATAD3A 55210 52001 0.1195 0.0342
GSE53624 ATAD3A 55210 52001 0.6179 0.0000
GSE63941 ATAD3A 55210 227700_x_at 0.3609 0.0975
GSE77861 ATAD3A 55210 227700_x_at 0.0488 0.7138
GSE97050 ATAD3A 55210 A_33_P3349469 0.2121 0.5930
SRP007169 ATAD3A 55210 RNAseq 0.3185 0.5548
SRP008496 ATAD3A 55210 RNAseq 0.4972 0.1946
SRP064894 ATAD3A 55210 RNAseq 1.0408 0.0000
SRP133303 ATAD3A 55210 RNAseq 0.7894 0.0010
SRP159526 ATAD3A 55210 RNAseq 0.5607 0.1041
SRP193095 ATAD3A 55210 RNAseq 0.6375 0.0000
SRP219564 ATAD3A 55210 RNAseq 0.7333 0.0430
TCGA ATAD3A 55210 RNAseq 0.2274 0.0022

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ATAD3A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATAD3A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATAD3A 55210 3 7 20
GSE20123 ATAD3A 55210 3 6 21
GSE43470 ATAD3A 55210 3 5 35
GSE46452 ATAD3A 55210 7 1 51
GSE47630 ATAD3A 55210 8 4 28
GSE54993 ATAD3A 55210 2 2 66
GSE54994 ATAD3A 55210 15 2 36
GSE60625 ATAD3A 55210 0 0 11
GSE74703 ATAD3A 55210 3 3 30
GSE74704 ATAD3A 55210 3 0 17
TCGA ATAD3A 55210 14 20 62

Total number of gains: 61; Total number of losses: 50; Total Number of normals: 377.  

 

Somatic mutations of ATAD3A:

 

Generating mutation plots.

 

Highly correlated genes for ATAD3A:

 

Showing top 20/828 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATAD3AATAD3B0.859446808
ATAD3AWRAP730.729021404
ATAD3ACCDC860.704198404
ATAD3ABRIX10.704058404
ATAD3ACNPY30.70399303
ATAD3ARNF20.701593303
ATAD3AHDAC70.700052303
ATAD3ACOMMD70.695174303
ATAD3AAP2A10.69404504
ATAD3AMEA10.693424303
ATAD3AARMC60.692964606
ATAD3ARBM150.689474403
ATAD3ANOP140.683064505
ATAD3ADNASE20.683017303
ATAD3AGPATCH40.682391404
ATAD3ALRFN40.681957303
ATAD3ANOC2L0.680315605
ATAD3APPP1R370.678265404
ATAD3AMTERF30.677427303
ATAD3APSMB40.677092303

For details and further investigation, click here