BRIX1

 

Full name: biogenesis of ribosomes BRX1 Alias Symbol: BRIX|FLJ11100
Type: protein-coding gene Cytoband: 5p13.2
Entrez ID: 55299 HGNC ID: HGNC:24170 Ensembl Gene: ENSG00000113460 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of BRIX1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BRIX1 55299 219177_at 1.2266 0.0286
GSE20347 BRIX1 55299 219177_at 1.0374 0.0000
GSE23400 BRIX1 55299 219177_at 0.4557 0.0000
GSE26886 BRIX1 55299 219177_at 1.5149 0.0000
GSE29001 BRIX1 55299 219177_at 0.9933 0.0003
GSE38129 BRIX1 55299 219177_at 1.0908 0.0000
GSE45670 BRIX1 55299 219177_at 0.6705 0.0018
GSE53622 BRIX1 55299 130500 0.9377 0.0000
GSE53624 BRIX1 55299 130500 1.2234 0.0000
GSE63941 BRIX1 55299 219177_at 0.3415 0.2047
GSE77861 BRIX1 55299 219177_at 0.9249 0.0271
GSE97050 BRIX1 55299 A_23_P252855 0.8318 0.0976
SRP007169 BRIX1 55299 RNAseq 1.0266 0.0087
SRP008496 BRIX1 55299 RNAseq 1.0308 0.0036
SRP064894 BRIX1 55299 RNAseq 0.3914 0.0461
SRP133303 BRIX1 55299 RNAseq 0.7409 0.0015
SRP159526 BRIX1 55299 RNAseq 1.0175 0.0100
SRP193095 BRIX1 55299 RNAseq 0.4787 0.0010
SRP219564 BRIX1 55299 RNAseq 0.6587 0.0195
TCGA BRIX1 55299 RNAseq 0.4254 0.0000

Upregulated datasets: 8; Downregulated datasets: 0.  

 

Survival by BRIX1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BRIX1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BRIX1 55299 10 0 20
GSE20123 BRIX1 55299 10 0 20
GSE43470 BRIX1 55299 18 0 25
GSE46452 BRIX1 55299 6 21 32
GSE47630 BRIX1 55299 6 12 22
GSE54993 BRIX1 55299 5 4 61
GSE54994 BRIX1 55299 26 2 25
GSE60625 BRIX1 55299 0 0 11
GSE74703 BRIX1 55299 14 0 22
GSE74704 BRIX1 55299 9 0 11
TCGA BRIX1 55299 52 6 38

Total number of gains: 156; Total number of losses: 45; Total Number of normals: 287.  

 

Somatic mutations of BRIX1:

 

Generating mutation plots.

 

Highly correlated genes for BRIX1:

 

Showing top 20/2171 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BRIX1PYCR20.805581303
BRIX1NOP560.791429303
BRIX1ECT20.7911510010
BRIX1NUP1550.78649812011
BRIX1MET0.784736909
BRIX1TRIP130.7839712012
BRIX1SLC25A320.76864311011
BRIX1UBE2C0.76643312011
BRIX1SIX40.764968707
BRIX1ACTL6A0.76292812012
BRIX1B3GALT60.759284606
BRIX1ICE10.75821710010
BRIX1DNAJC20.75664312011
BRIX1FMNL20.756329707
BRIX1CENPF0.75537611011
BRIX1ZSCAN210.75533404
BRIX1MMS22L0.753014303
BRIX1PLXNA10.75273611011
BRIX1U2SURP0.752082909
BRIX1SPC250.751449909

For details and further investigation, click here