| Full name: deoxyribonuclease 2, lysosomal | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 1777 | HGNC ID: HGNC:2960 | Ensembl Gene: ENSG00000105612 | OMIM ID: 126350 |
| Drug and gene relationship at DGIdb | |||
Expression of DNASE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNASE2 | 1777 | 209831_x_at | 0.3342 | 0.2617 | |
| GSE20347 | DNASE2 | 1777 | 209831_x_at | 0.3838 | 0.0008 | |
| GSE23400 | DNASE2 | 1777 | 209831_x_at | 0.1315 | 0.0062 | |
| GSE26886 | DNASE2 | 1777 | 209831_x_at | 0.6075 | 0.0002 | |
| GSE29001 | DNASE2 | 1777 | 209831_x_at | 0.1455 | 0.2875 | |
| GSE38129 | DNASE2 | 1777 | 209831_x_at | 0.2494 | 0.0049 | |
| GSE45670 | DNASE2 | 1777 | 209831_x_at | 0.3577 | 0.0133 | |
| GSE53622 | DNASE2 | 1777 | 24254 | 0.7896 | 0.0000 | |
| GSE53624 | DNASE2 | 1777 | 24254 | 0.7427 | 0.0000 | |
| GSE63941 | DNASE2 | 1777 | 209831_x_at | 0.4660 | 0.1073 | |
| GSE77861 | DNASE2 | 1777 | 209831_x_at | 0.7183 | 0.0097 | |
| GSE97050 | DNASE2 | 1777 | A_23_P119266 | 0.4342 | 0.1860 | |
| SRP007169 | DNASE2 | 1777 | RNAseq | 0.7175 | 0.0647 | |
| SRP008496 | DNASE2 | 1777 | RNAseq | 0.7947 | 0.0005 | |
| SRP064894 | DNASE2 | 1777 | RNAseq | 1.2804 | 0.0000 | |
| SRP133303 | DNASE2 | 1777 | RNAseq | 0.7344 | 0.0000 | |
| SRP159526 | DNASE2 | 1777 | RNAseq | 0.6863 | 0.0380 | |
| SRP193095 | DNASE2 | 1777 | RNAseq | 0.4761 | 0.0003 | |
| SRP219564 | DNASE2 | 1777 | RNAseq | 0.9116 | 0.0249 | |
| TCGA | DNASE2 | 1777 | RNAseq | 0.0979 | 0.0749 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DNASE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNASE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNASE2 | 1777 | 4 | 2 | 24 | |
| GSE20123 | DNASE2 | 1777 | 3 | 1 | 26 | |
| GSE43470 | DNASE2 | 1777 | 2 | 6 | 35 | |
| GSE46452 | DNASE2 | 1777 | 47 | 1 | 11 | |
| GSE47630 | DNASE2 | 1777 | 4 | 7 | 29 | |
| GSE54993 | DNASE2 | 1777 | 16 | 3 | 51 | |
| GSE54994 | DNASE2 | 1777 | 8 | 13 | 32 | |
| GSE60625 | DNASE2 | 1777 | 9 | 0 | 2 | |
| GSE74703 | DNASE2 | 1777 | 2 | 4 | 30 | |
| GSE74704 | DNASE2 | 1777 | 0 | 1 | 19 | |
| TCGA | DNASE2 | 1777 | 16 | 13 | 67 |
Total number of gains: 111; Total number of losses: 51; Total Number of normals: 326.
Somatic mutations of DNASE2:
Generating mutation plots.
Highly correlated genes for DNASE2:
Showing top 20/1454 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNASE2 | SMARCAD1 | 0.810068 | 3 | 0 | 3 |
| DNASE2 | POLA1 | 0.803934 | 3 | 0 | 3 |
| DNASE2 | RAD18 | 0.800012 | 3 | 0 | 3 |
| DNASE2 | UROS | 0.784136 | 3 | 0 | 3 |
| DNASE2 | METAP1D | 0.775713 | 3 | 0 | 3 |
| DNASE2 | GCC1 | 0.763155 | 4 | 0 | 4 |
| DNASE2 | KTI12 | 0.756561 | 3 | 0 | 3 |
| DNASE2 | AURKAIP1 | 0.754196 | 4 | 0 | 3 |
| DNASE2 | SLC35B2 | 0.752394 | 3 | 0 | 3 |
| DNASE2 | NACC1 | 0.744899 | 4 | 0 | 3 |
| DNASE2 | FBXW9 | 0.736662 | 4 | 0 | 4 |
| DNASE2 | ALKBH6 | 0.736624 | 4 | 0 | 4 |
| DNASE2 | API5 | 0.735277 | 3 | 0 | 3 |
| DNASE2 | LSM2 | 0.729263 | 4 | 0 | 4 |
| DNASE2 | RICTOR | 0.729137 | 3 | 0 | 3 |
| DNASE2 | PHOSPHO2 | 0.728658 | 3 | 0 | 3 |
| DNASE2 | DHRSX | 0.72849 | 3 | 0 | 3 |
| DNASE2 | CHCHD6 | 0.723805 | 5 | 0 | 5 |
| DNASE2 | PYCR2 | 0.723192 | 3 | 0 | 3 |
| DNASE2 | GLT8D1 | 0.722336 | 3 | 0 | 3 |
For details and further investigation, click here
