| Full name: coiled-coil domain containing 86 | Alias Symbol: MGC2574 | ||
| Type: protein-coding gene | Cytoband: 11q12.2 | ||
| Entrez ID: 79080 | HGNC ID: HGNC:28359 | Ensembl Gene: ENSG00000110104 | OMIM ID: 611293 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CCDC86:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCDC86 | 79080 | 203119_at | 0.6910 | 0.0197 | |
| GSE20347 | CCDC86 | 79080 | 203119_at | 0.7252 | 0.0004 | |
| GSE23400 | CCDC86 | 79080 | 203119_at | 0.5883 | 0.0000 | |
| GSE26886 | CCDC86 | 79080 | 203119_at | 1.9088 | 0.0000 | |
| GSE29001 | CCDC86 | 79080 | 203119_at | 0.3376 | 0.1837 | |
| GSE38129 | CCDC86 | 79080 | 203119_at | 0.8121 | 0.0000 | |
| GSE45670 | CCDC86 | 79080 | 203119_at | 0.7082 | 0.0001 | |
| GSE63941 | CCDC86 | 79080 | 203119_at | 0.6852 | 0.2393 | |
| GSE77861 | CCDC86 | 79080 | 203119_at | 0.9457 | 0.0046 | |
| GSE97050 | CCDC86 | 79080 | A_23_P161918 | 0.3542 | 0.4831 | |
| SRP007169 | CCDC86 | 79080 | RNAseq | 1.4241 | 0.0002 | |
| SRP008496 | CCDC86 | 79080 | RNAseq | 1.2190 | 0.0000 | |
| SRP064894 | CCDC86 | 79080 | RNAseq | 0.3185 | 0.0960 | |
| SRP133303 | CCDC86 | 79080 | RNAseq | 1.1571 | 0.0000 | |
| SRP159526 | CCDC86 | 79080 | RNAseq | 1.5206 | 0.0000 | |
| SRP193095 | CCDC86 | 79080 | RNAseq | 0.9776 | 0.0000 | |
| SRP219564 | CCDC86 | 79080 | RNAseq | 0.6701 | 0.0807 | |
| TCGA | CCDC86 | 79080 | RNAseq | 0.3122 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by CCDC86 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CCDC86:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCDC86 | 79080 | 2 | 5 | 23 | |
| GSE20123 | CCDC86 | 79080 | 2 | 5 | 23 | |
| GSE43470 | CCDC86 | 79080 | 2 | 6 | 35 | |
| GSE46452 | CCDC86 | 79080 | 8 | 4 | 47 | |
| GSE47630 | CCDC86 | 79080 | 3 | 8 | 29 | |
| GSE54993 | CCDC86 | 79080 | 3 | 0 | 67 | |
| GSE54994 | CCDC86 | 79080 | 5 | 5 | 43 | |
| GSE60625 | CCDC86 | 79080 | 0 | 3 | 8 | |
| GSE74703 | CCDC86 | 79080 | 2 | 3 | 31 | |
| GSE74704 | CCDC86 | 79080 | 2 | 3 | 15 | |
| TCGA | CCDC86 | 79080 | 15 | 10 | 71 |
Total number of gains: 44; Total number of losses: 52; Total Number of normals: 392.
Somatic mutations of CCDC86:
Generating mutation plots.
Highly correlated genes for CCDC86:
Showing top 20/1982 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCDC86 | DEPDC1B | 0.798506 | 3 | 0 | 3 |
| CCDC86 | SCYL1 | 0.781021 | 5 | 0 | 5 |
| CCDC86 | C1orf131 | 0.777886 | 5 | 0 | 5 |
| CCDC86 | PSMG3 | 0.774746 | 5 | 0 | 5 |
| CCDC86 | WDR66 | 0.772555 | 5 | 0 | 5 |
| CCDC86 | UBE2T | 0.769429 | 5 | 0 | 5 |
| CCDC86 | NUF2 | 0.76747 | 5 | 0 | 5 |
| CCDC86 | GMNN | 0.767043 | 8 | 0 | 8 |
| CCDC86 | DHX37 | 0.764796 | 4 | 0 | 4 |
| CCDC86 | ANLN | 0.760665 | 4 | 0 | 4 |
| CCDC86 | MSTO1 | 0.759296 | 5 | 0 | 4 |
| CCDC86 | RTKN | 0.759022 | 5 | 0 | 5 |
| CCDC86 | ATP11C | 0.758871 | 3 | 0 | 3 |
| CCDC86 | SHANK3 | 0.758809 | 3 | 0 | 3 |
| CCDC86 | PSME4 | 0.758536 | 8 | 0 | 8 |
| CCDC86 | BRAT1 | 0.757198 | 5 | 0 | 5 |
| CCDC86 | POLR1A | 0.756702 | 3 | 0 | 3 |
| CCDC86 | ITPR3 | 0.756458 | 8 | 0 | 8 |
| CCDC86 | CENPO | 0.755946 | 3 | 0 | 3 |
| CCDC86 | MPLKIP | 0.755799 | 4 | 0 | 4 |
For details and further investigation, click here
