Full name: activating transcription factor 2	Alias Symbol: TREB7|CRE-BP1|HB16
Type: protein-coding gene	Cytoband: 2q31.1
Entrez ID: 1386	HGNC ID: HGNC:784	Ensembl Gene: ENSG00000115966	OMIM ID: 123811
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 16/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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ATF2 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04668	TNF signaling pathway	View
hsa04728	Dopaminergic synapse	View
hsa04911	Insulin secretion	View
hsa04915	Estrogen signaling pathway	View
hsa04918	Thyroid hormone synthesis	View
hsa04922	Glucagon signaling pathway	View
hsa04925	Aldosterone synthesis and secretion	View
hsa05030	Cocaine addiction	View
hsa05031	Amphetamine addiction	View
hsa05034	Alcoholism	View
hsa05161	Hepatitis B	View
hsa05164	Influenza A	View
hsa05166	HTLV-I infection	View
hsa05169	Epstein-Barr virus infection	View

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Expression of ATF2:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ATF2	1386	212984_at	0.4297	0.2698	Show
GSE20347	ATF2	1386	212984_at	0.3596	0.0297	Show
GSE23400	ATF2	1386	205446_s_at	0.2357	0.0000	Show
GSE26886	ATF2	1386	212984_at	0.9815	0.0000	Show
GSE29001	ATF2	1386	212984_at	0.3663	0.4745	Show
GSE38129	ATF2	1386	212984_at	0.2511	0.0722	Show
GSE45670	ATF2	1386	212984_at	-0.0929	0.6625	Show
GSE53622	ATF2	1386	6889	0.4368	0.0000	Show
GSE53624	ATF2	1386	115039	0.1957	0.0016	Show
GSE63941	ATF2	1386	212984_at	-0.7152	0.1078	Show
GSE77861	ATF2	1386	212984_at	0.3715	0.0702	Show
GSE97050	ATF2	1386	A_24_P128145	0.0882	0.7519	Show
SRP007169	ATF2	1386	RNAseq	0.7283	0.0849	Show
SRP008496	ATF2	1386	RNAseq	0.6682	0.0033	Show
SRP064894	ATF2	1386	RNAseq	0.3553	0.0967	Show
SRP133303	ATF2	1386	RNAseq	0.4533	0.0004	Show
SRP159526	ATF2	1386	RNAseq	0.1674	0.4198	Show
SRP193095	ATF2	1386	RNAseq	0.1118	0.2705	Show
SRP219564	ATF2	1386	RNAseq	0.1378	0.5980	Show
TCGA	ATF2	1386	RNAseq	-0.0269	0.6459	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by ATF2 expression:

 

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Copy number change of ATF2:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ATF2	1386	9	0	21	Show
GSE20123	ATF2	1386	9	0	21	Show
GSE43470	ATF2	1386	5	1	37	Show
GSE46452	ATF2	1386	1	4	54	Show
GSE47630	ATF2	1386	5	3	32	Show
GSE54993	ATF2	1386	0	5	65	Show
GSE54994	ATF2	1386	12	3	38	Show
GSE60625	ATF2	1386	0	3	8	Show
GSE74703	ATF2	1386	4	1	31	Show
GSE74704	ATF2	1386	5	0	15	Show
TCGA	ATF2	1386	28	5	63	Show

Total number of gains: 78; Total number of losses: 25; Total Number of normals: 385.  Download Data

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Somatic mutations of ATF2:

 

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Highly correlated genes for ATF2:

 

Showing top 20/1091 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ATF2	IDS	0.793975	3	0	3
ATF2	PPRC1	0.753038	3	0	3
ATF2	NOL9	0.738916	3	0	3
ATF2	CEP170	0.730338	3	0	3
ATF2	EIF3M	0.729234	3	0	3
ATF2	BRAP	0.711157	4	0	4
ATF2	SP3	0.710765	10	0	10
ATF2	SLC38A10	0.707117	3	0	3
ATF2	RNF139	0.704488	4	0	3
ATF2	WDR81	0.703638	3	0	3
ATF2	SEC22A	0.702659	4	0	3
ATF2	ALKBH6	0.702656	4	0	4
ATF2	HES6	0.697792	3	0	3
ATF2	RNMT	0.690979	4	0	4
ATF2	JMY	0.690529	3	0	3
ATF2	SS18L1	0.688144	3	0	3
ATF2	SLC36A4	0.686262	3	0	3
ATF2	NOL8	0.684623	5	0	4
ATF2	EIF2S2	0.682728	3	0	3
ATF2	ZBTB26	0.681828	4	0	4

For details and further investigation, click here