| Full name: eukaryotic translation initiation factor 2 subunit beta | Alias Symbol: EIF2beta|PPP1R67 | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 8894 | HGNC ID: HGNC:3266 | Ensembl Gene: ENSG00000125977 | OMIM ID: 603908 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF2S2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2S2 | 8894 | 208726_s_at | 0.3035 | 0.4476 | |
| GSE20347 | EIF2S2 | 8894 | 208726_s_at | 0.2614 | 0.1643 | |
| GSE23400 | EIF2S2 | 8894 | 208726_s_at | 0.3163 | 0.0000 | |
| GSE26886 | EIF2S2 | 8894 | 208726_s_at | -0.2937 | 0.2131 | |
| GSE29001 | EIF2S2 | 8894 | 208726_s_at | 0.2152 | 0.7734 | |
| GSE38129 | EIF2S2 | 8894 | 208726_s_at | 0.4554 | 0.0008 | |
| GSE45670 | EIF2S2 | 8894 | 208726_s_at | 0.2130 | 0.1266 | |
| GSE53622 | EIF2S2 | 8894 | 16985 | 0.3865 | 0.0000 | |
| GSE53624 | EIF2S2 | 8894 | 16985 | 0.2652 | 0.0020 | |
| GSE63941 | EIF2S2 | 8894 | 208726_s_at | 0.8482 | 0.0050 | |
| GSE77861 | EIF2S2 | 8894 | 208726_s_at | 0.6168 | 0.0273 | |
| GSE97050 | EIF2S2 | 8894 | A_32_P157965 | 0.3305 | 0.3732 | |
| SRP007169 | EIF2S2 | 8894 | RNAseq | -0.5839 | 0.1007 | |
| SRP008496 | EIF2S2 | 8894 | RNAseq | -0.1979 | 0.4165 | |
| SRP064894 | EIF2S2 | 8894 | RNAseq | 0.2349 | 0.1853 | |
| SRP133303 | EIF2S2 | 8894 | RNAseq | 0.3932 | 0.0053 | |
| SRP159526 | EIF2S2 | 8894 | RNAseq | -0.0442 | 0.8510 | |
| SRP193095 | EIF2S2 | 8894 | RNAseq | -0.1651 | 0.1561 | |
| SRP219564 | EIF2S2 | 8894 | RNAseq | 0.0167 | 0.9538 | |
| TCGA | EIF2S2 | 8894 | RNAseq | 0.1045 | 0.0320 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF2S2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2S2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2S2 | 8894 | 15 | 0 | 15 | |
| GSE20123 | EIF2S2 | 8894 | 15 | 0 | 15 | |
| GSE43470 | EIF2S2 | 8894 | 12 | 0 | 31 | |
| GSE46452 | EIF2S2 | 8894 | 29 | 0 | 30 | |
| GSE47630 | EIF2S2 | 8894 | 24 | 1 | 15 | |
| GSE54993 | EIF2S2 | 8894 | 0 | 18 | 52 | |
| GSE54994 | EIF2S2 | 8894 | 25 | 1 | 27 | |
| GSE60625 | EIF2S2 | 8894 | 0 | 0 | 11 | |
| GSE74703 | EIF2S2 | 8894 | 11 | 0 | 25 | |
| GSE74704 | EIF2S2 | 8894 | 10 | 0 | 10 | |
| TCGA | EIF2S2 | 8894 | 51 | 1 | 44 |
Total number of gains: 192; Total number of losses: 21; Total Number of normals: 275.
Somatic mutations of EIF2S2:
Generating mutation plots.
Highly correlated genes for EIF2S2:
Showing top 20/1007 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2S2 | MRPL30 | 0.836221 | 3 | 0 | 3 |
| EIF2S2 | RPS6KB1 | 0.795103 | 3 | 0 | 3 |
| EIF2S2 | FBXW2 | 0.775101 | 3 | 0 | 3 |
| EIF2S2 | TRADD | 0.772442 | 3 | 0 | 3 |
| EIF2S2 | DNAJC1 | 0.769492 | 3 | 0 | 3 |
| EIF2S2 | AP1AR | 0.763546 | 4 | 0 | 4 |
| EIF2S2 | STAM2 | 0.733473 | 4 | 0 | 4 |
| EIF2S2 | STX6 | 0.727666 | 3 | 0 | 3 |
| EIF2S2 | DUS3L | 0.727566 | 3 | 0 | 3 |
| EIF2S2 | NEMF | 0.723276 | 4 | 0 | 4 |
| EIF2S2 | MRPS31 | 0.722922 | 3 | 0 | 3 |
| EIF2S2 | EIF4G2 | 0.713187 | 3 | 0 | 3 |
| EIF2S2 | UBTD2 | 0.712524 | 3 | 0 | 3 |
| EIF2S2 | BZW1 | 0.710342 | 5 | 0 | 4 |
| EIF2S2 | PPM1D | 0.708402 | 3 | 0 | 3 |
| EIF2S2 | USP8 | 0.707497 | 3 | 0 | 3 |
| EIF2S2 | VPS26A | 0.705786 | 4 | 0 | 4 |
| EIF2S2 | NMT1 | 0.704508 | 7 | 0 | 7 |
| EIF2S2 | IRF2BPL | 0.703846 | 3 | 0 | 3 |
| EIF2S2 | DCP2 | 0.701536 | 3 | 0 | 3 |
For details and further investigation, click here
