| Full name: syntaxin binding protein 2 | Alias Symbol: UNC18B|Hunc18b | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 6813 | HGNC ID: HGNC:11445 | Ensembl Gene: ENSG00000076944 | OMIM ID: 601717 |
| Drug and gene relationship at DGIdb | |||
Expression of STXBP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STXBP2 | 6813 | 209367_at | 0.1378 | 0.8475 | |
| GSE20347 | STXBP2 | 6813 | 209367_at | -0.5829 | 0.0000 | |
| GSE23400 | STXBP2 | 6813 | 209367_at | -0.1636 | 0.0437 | |
| GSE26886 | STXBP2 | 6813 | 1570420_at | -0.3272 | 0.0139 | |
| GSE29001 | STXBP2 | 6813 | 209367_at | -0.4048 | 0.0751 | |
| GSE38129 | STXBP2 | 6813 | 209367_at | -0.1224 | 0.5910 | |
| GSE45670 | STXBP2 | 6813 | 209367_at | 0.1004 | 0.3585 | |
| GSE53622 | STXBP2 | 6813 | 173000 | -0.2177 | 0.0365 | |
| GSE53624 | STXBP2 | 6813 | 173000 | -0.2904 | 0.0000 | |
| GSE63941 | STXBP2 | 6813 | 209367_at | 2.0022 | 0.0001 | |
| GSE77861 | STXBP2 | 6813 | 209367_at | -0.0469 | 0.8736 | |
| GSE97050 | STXBP2 | 6813 | A_33_P3388835 | 0.4937 | 0.3907 | |
| SRP007169 | STXBP2 | 6813 | RNAseq | -1.0766 | 0.0069 | |
| SRP008496 | STXBP2 | 6813 | RNAseq | -1.0170 | 0.0001 | |
| SRP064894 | STXBP2 | 6813 | RNAseq | 0.1238 | 0.6140 | |
| SRP133303 | STXBP2 | 6813 | RNAseq | -0.3134 | 0.1005 | |
| SRP159526 | STXBP2 | 6813 | RNAseq | -0.5112 | 0.0547 | |
| SRP193095 | STXBP2 | 6813 | RNAseq | -0.3677 | 0.0412 | |
| SRP219564 | STXBP2 | 6813 | RNAseq | 0.7676 | 0.2963 | |
| TCGA | STXBP2 | 6813 | RNAseq | 0.0185 | 0.7880 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by STXBP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STXBP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STXBP2 | 6813 | 5 | 3 | 22 | |
| GSE20123 | STXBP2 | 6813 | 4 | 2 | 24 | |
| GSE43470 | STXBP2 | 6813 | 2 | 6 | 35 | |
| GSE46452 | STXBP2 | 6813 | 47 | 1 | 11 | |
| GSE47630 | STXBP2 | 6813 | 5 | 7 | 28 | |
| GSE54993 | STXBP2 | 6813 | 16 | 3 | 51 | |
| GSE54994 | STXBP2 | 6813 | 6 | 13 | 34 | |
| GSE60625 | STXBP2 | 6813 | 9 | 0 | 2 | |
| GSE74703 | STXBP2 | 6813 | 2 | 4 | 30 | |
| GSE74704 | STXBP2 | 6813 | 1 | 2 | 17 | |
| TCGA | STXBP2 | 6813 | 9 | 20 | 67 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of STXBP2:
Generating mutation plots.
Highly correlated genes for STXBP2:
Showing top 20/664 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STXBP2 | MAL2 | 0.73808 | 5 | 0 | 4 |
| STXBP2 | AP1S3 | 0.723041 | 3 | 0 | 3 |
| STXBP2 | RTKN2 | 0.720602 | 3 | 0 | 3 |
| STXBP2 | FAM83H | 0.69425 | 5 | 0 | 5 |
| STXBP2 | STAP2 | 0.689042 | 8 | 0 | 7 |
| STXBP2 | MVB12A | 0.685983 | 5 | 0 | 4 |
| STXBP2 | TXNDC2 | 0.677805 | 4 | 0 | 4 |
| STXBP2 | CHMP4C | 0.677792 | 4 | 0 | 3 |
| STXBP2 | DRD3 | 0.676509 | 3 | 0 | 3 |
| STXBP2 | SDC1 | 0.672588 | 11 | 0 | 8 |
| STXBP2 | CAPZA1 | 0.670868 | 5 | 0 | 4 |
| STXBP2 | GRHL2 | 0.66925 | 6 | 0 | 5 |
| STXBP2 | ATP2A2 | 0.666848 | 5 | 0 | 4 |
| STXBP2 | MAPK13 | 0.663669 | 10 | 0 | 8 |
| STXBP2 | TECR | 0.663175 | 12 | 0 | 10 |
| STXBP2 | ATAD3C | 0.660169 | 3 | 0 | 3 |
| STXBP2 | LRFN1 | 0.65887 | 3 | 0 | 3 |
| STXBP2 | SEC24C | 0.656106 | 5 | 0 | 5 |
| STXBP2 | CDS1 | 0.655648 | 9 | 0 | 6 |
| STXBP2 | SEMA3F | 0.651266 | 9 | 0 | 8 |
For details and further investigation, click here
