| Full name: eukaryotic translation initiation factor 4 gamma 1 | Alias Symbol: p220|PARK18 | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 1981 | HGNC ID: HGNC:3296 | Ensembl Gene: ENSG00000114867 | OMIM ID: 600495 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EIF4G1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF4G1 | 1981 | 208625_s_at | 0.4529 | 0.2048 | |
| GSE20347 | EIF4G1 | 1981 | 208625_s_at | 0.3136 | 0.0091 | |
| GSE23400 | EIF4G1 | 1981 | 208625_s_at | 0.3393 | 0.0000 | |
| GSE26886 | EIF4G1 | 1981 | 208624_s_at | -0.5618 | 0.0018 | |
| GSE29001 | EIF4G1 | 1981 | 208625_s_at | 0.1505 | 0.7198 | |
| GSE38129 | EIF4G1 | 1981 | 208625_s_at | 0.5220 | 0.0000 | |
| GSE45670 | EIF4G1 | 1981 | 208625_s_at | 0.5875 | 0.0005 | |
| GSE53622 | EIF4G1 | 1981 | 4711 | 0.6251 | 0.0000 | |
| GSE53624 | EIF4G1 | 1981 | 4711 | 0.5586 | 0.0000 | |
| GSE63941 | EIF4G1 | 1981 | 208625_s_at | 0.1537 | 0.7580 | |
| GSE77861 | EIF4G1 | 1981 | 208625_s_at | 0.3596 | 0.1319 | |
| GSE97050 | EIF4G1 | 1981 | A_23_P218892 | 0.4411 | 0.2528 | |
| SRP007169 | EIF4G1 | 1981 | RNAseq | 1.6321 | 0.0006 | |
| SRP008496 | EIF4G1 | 1981 | RNAseq | 1.2402 | 0.0002 | |
| SRP064894 | EIF4G1 | 1981 | RNAseq | 0.3040 | 0.1196 | |
| SRP133303 | EIF4G1 | 1981 | RNAseq | 0.5948 | 0.0005 | |
| SRP159526 | EIF4G1 | 1981 | RNAseq | 0.6173 | 0.0167 | |
| SRP193095 | EIF4G1 | 1981 | RNAseq | 0.4818 | 0.0007 | |
| SRP219564 | EIF4G1 | 1981 | RNAseq | -0.0782 | 0.8030 | |
| TCGA | EIF4G1 | 1981 | RNAseq | 0.0992 | 0.0158 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by EIF4G1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF4G1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF4G1 | 1981 | 25 | 0 | 5 | |
| GSE20123 | EIF4G1 | 1981 | 25 | 0 | 5 | |
| GSE43470 | EIF4G1 | 1981 | 25 | 0 | 18 | |
| GSE46452 | EIF4G1 | 1981 | 19 | 1 | 39 | |
| GSE47630 | EIF4G1 | 1981 | 27 | 2 | 11 | |
| GSE54993 | EIF4G1 | 1981 | 1 | 19 | 50 | |
| GSE54994 | EIF4G1 | 1981 | 41 | 0 | 12 | |
| GSE60625 | EIF4G1 | 1981 | 0 | 6 | 5 | |
| GSE74703 | EIF4G1 | 1981 | 21 | 0 | 15 | |
| GSE74704 | EIF4G1 | 1981 | 17 | 0 | 3 | |
| TCGA | EIF4G1 | 1981 | 77 | 0 | 19 |
Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.
Somatic mutations of EIF4G1:
Generating mutation plots.
Highly correlated genes for EIF4G1:
Showing top 20/665 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF4G1 | ZNF142 | 0.838248 | 3 | 0 | 3 |
| EIF4G1 | PSMD2 | 0.773047 | 12 | 0 | 12 |
| EIF4G1 | SPCS2 | 0.760121 | 3 | 0 | 3 |
| EIF4G1 | RNF166 | 0.741417 | 3 | 0 | 3 |
| EIF4G1 | ALG3 | 0.72974 | 11 | 0 | 11 |
| EIF4G1 | ABCF3 | 0.728006 | 13 | 0 | 12 |
| EIF4G1 | LEMD2 | 0.722999 | 3 | 0 | 3 |
| EIF4G1 | APEH | 0.72276 | 3 | 0 | 3 |
| EIF4G1 | TMEM203 | 0.720019 | 3 | 0 | 3 |
| EIF4G1 | TMEM189 | 0.71995 | 3 | 0 | 3 |
| EIF4G1 | DDIAS | 0.719487 | 3 | 0 | 3 |
| EIF4G1 | COMMD2 | 0.715284 | 4 | 0 | 4 |
| EIF4G1 | DGKQ | 0.714019 | 4 | 0 | 3 |
| EIF4G1 | ZNF765 | 0.711352 | 3 | 0 | 3 |
| EIF4G1 | RNF4 | 0.709987 | 4 | 0 | 3 |
| EIF4G1 | TBC1D22B | 0.708875 | 3 | 0 | 3 |
| EIF4G1 | C12orf60 | 0.706424 | 3 | 0 | 3 |
| EIF4G1 | DNAJC19 | 0.705704 | 4 | 0 | 4 |
| EIF4G1 | KANSL2 | 0.704265 | 3 | 0 | 3 |
| EIF4G1 | GART | 0.700693 | 7 | 0 | 7 |
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