| Full name: ADAM metallopeptidase domain 15 | Alias Symbol: MDC15 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 8751 | HGNC ID: HGNC:193 | Ensembl Gene: ENSG00000143537 | OMIM ID: 605548 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAM15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAM15 | 8751 | 1555896_a_at | 0.4819 | 0.1033 | |
| GSE20347 | ADAM15 | 8751 | 217007_s_at | -0.1603 | 0.0583 | |
| GSE23400 | ADAM15 | 8751 | 217007_s_at | -0.0950 | 0.1721 | |
| GSE26886 | ADAM15 | 8751 | 1555896_a_at | -0.3199 | 0.0535 | |
| GSE29001 | ADAM15 | 8751 | 217007_s_at | -0.0373 | 0.8386 | |
| GSE38129 | ADAM15 | 8751 | 217007_s_at | -0.1551 | 0.0377 | |
| GSE45670 | ADAM15 | 8751 | 1555896_a_at | 0.0426 | 0.7707 | |
| GSE53622 | ADAM15 | 8751 | 1556 | -0.7308 | 0.0000 | |
| GSE53624 | ADAM15 | 8751 | 1556 | -0.4028 | 0.0000 | |
| GSE63941 | ADAM15 | 8751 | 1555896_a_at | 0.8558 | 0.0079 | |
| GSE77861 | ADAM15 | 8751 | 1555896_a_at | -0.2204 | 0.3015 | |
| GSE97050 | ADAM15 | 8751 | A_33_P3380693 | 0.0960 | 0.7083 | |
| SRP007169 | ADAM15 | 8751 | RNAseq | -2.1103 | 0.0000 | |
| SRP008496 | ADAM15 | 8751 | RNAseq | -1.6728 | 0.0000 | |
| SRP064894 | ADAM15 | 8751 | RNAseq | -0.1316 | 0.5003 | |
| SRP133303 | ADAM15 | 8751 | RNAseq | -0.4413 | 0.0015 | |
| SRP159526 | ADAM15 | 8751 | RNAseq | -0.2404 | 0.5812 | |
| SRP193095 | ADAM15 | 8751 | RNAseq | -0.1944 | 0.1281 | |
| SRP219564 | ADAM15 | 8751 | RNAseq | 0.2599 | 0.6057 | |
| TCGA | ADAM15 | 8751 | RNAseq | -0.0060 | 0.9064 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ADAM15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAM15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAM15 | 8751 | 14 | 0 | 16 | |
| GSE20123 | ADAM15 | 8751 | 13 | 0 | 17 | |
| GSE43470 | ADAM15 | 8751 | 6 | 2 | 35 | |
| GSE46452 | ADAM15 | 8751 | 2 | 1 | 56 | |
| GSE47630 | ADAM15 | 8751 | 14 | 0 | 26 | |
| GSE54993 | ADAM15 | 8751 | 0 | 4 | 66 | |
| GSE54994 | ADAM15 | 8751 | 16 | 0 | 37 | |
| GSE60625 | ADAM15 | 8751 | 0 | 0 | 11 | |
| GSE74703 | ADAM15 | 8751 | 6 | 1 | 29 | |
| GSE74704 | ADAM15 | 8751 | 6 | 0 | 14 | |
| TCGA | ADAM15 | 8751 | 38 | 2 | 56 |
Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.
Somatic mutations of ADAM15:
Generating mutation plots.
Highly correlated genes for ADAM15:
Showing top 20/659 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAM15 | SARS2 | 0.830447 | 3 | 0 | 3 |
| ADAM15 | TRIM28 | 0.811898 | 3 | 0 | 3 |
| ADAM15 | SCAMP3 | 0.794039 | 3 | 0 | 3 |
| ADAM15 | CXCL16 | 0.763909 | 3 | 0 | 3 |
| ADAM15 | TRUB2 | 0.75123 | 3 | 0 | 3 |
| ADAM15 | XPNPEP1 | 0.7459 | 3 | 0 | 3 |
| ADAM15 | SNRPA | 0.743634 | 3 | 0 | 3 |
| ADAM15 | HPS4 | 0.741335 | 3 | 0 | 3 |
| ADAM15 | ZNF408 | 0.738799 | 4 | 0 | 4 |
| ADAM15 | REL | 0.732344 | 3 | 0 | 3 |
| ADAM15 | PLCB2 | 0.73188 | 3 | 0 | 3 |
| ADAM15 | PRKD2 | 0.731642 | 3 | 0 | 3 |
| ADAM15 | WDR37 | 0.731593 | 3 | 0 | 3 |
| ADAM15 | HDGF | 0.723755 | 3 | 0 | 3 |
| ADAM15 | ATG2A | 0.723319 | 3 | 0 | 3 |
| ADAM15 | TSEN54 | 0.723274 | 3 | 0 | 3 |
| ADAM15 | IMPDH1 | 0.722325 | 4 | 0 | 3 |
| ADAM15 | RNF149 | 0.722009 | 3 | 0 | 3 |
| ADAM15 | KIAA1522 | 0.720351 | 4 | 0 | 4 |
| ADAM15 | GNGT2 | 0.719278 | 3 | 0 | 3 |
For details and further investigation, click here
