| Full name: protein kinase N1 | Alias Symbol: DBK|PRK1|PKN|MGC46204|PAK1 | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 5585 | HGNC ID: HGNC:9405 | Ensembl Gene: ENSG00000123143 | OMIM ID: 601032 |
| Drug and gene relationship at DGIdb | |||
PKN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa05132 | Salmonella infection |
Expression of PKN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKN1 | 5585 | 202161_at | 0.2975 | 0.5870 | |
| GSE20347 | PKN1 | 5585 | 202161_at | 0.3216 | 0.0894 | |
| GSE23400 | PKN1 | 5585 | 202161_at | 0.0165 | 0.8863 | |
| GSE26886 | PKN1 | 5585 | 202161_at | 0.4476 | 0.0172 | |
| GSE29001 | PKN1 | 5585 | 202161_at | 0.2269 | 0.3208 | |
| GSE38129 | PKN1 | 5585 | 202161_at | 0.2095 | 0.5054 | |
| GSE45670 | PKN1 | 5585 | 202161_at | 0.0772 | 0.4965 | |
| GSE53622 | PKN1 | 5585 | 97297 | 0.2679 | 0.0337 | |
| GSE53624 | PKN1 | 5585 | 97297 | 0.7339 | 0.0000 | |
| GSE63941 | PKN1 | 5585 | 202161_at | 0.3709 | 0.4694 | |
| GSE77861 | PKN1 | 5585 | 202161_at | 0.4703 | 0.0253 | |
| GSE97050 | PKN1 | 5585 | A_23_P67271 | -0.0176 | 0.9611 | |
| SRP007169 | PKN1 | 5585 | RNAseq | 1.4078 | 0.0062 | |
| SRP008496 | PKN1 | 5585 | RNAseq | 1.9649 | 0.0000 | |
| SRP064894 | PKN1 | 5585 | RNAseq | 0.9899 | 0.0132 | |
| SRP133303 | PKN1 | 5585 | RNAseq | 0.1615 | 0.4433 | |
| SRP159526 | PKN1 | 5585 | RNAseq | 0.5636 | 0.0055 | |
| SRP193095 | PKN1 | 5585 | RNAseq | 0.9033 | 0.0028 | |
| SRP219564 | PKN1 | 5585 | RNAseq | 0.7780 | 0.2772 | |
| TCGA | PKN1 | 5585 | RNAseq | -0.2412 | 0.0069 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PKN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKN1 | 5585 | 4 | 2 | 24 | |
| GSE20123 | PKN1 | 5585 | 3 | 1 | 26 | |
| GSE43470 | PKN1 | 5585 | 2 | 6 | 35 | |
| GSE46452 | PKN1 | 5585 | 47 | 1 | 11 | |
| GSE47630 | PKN1 | 5585 | 4 | 7 | 29 | |
| GSE54993 | PKN1 | 5585 | 15 | 4 | 51 | |
| GSE54994 | PKN1 | 5585 | 6 | 13 | 34 | |
| GSE60625 | PKN1 | 5585 | 9 | 0 | 2 | |
| GSE74703 | PKN1 | 5585 | 2 | 4 | 30 | |
| GSE74704 | PKN1 | 5585 | 0 | 1 | 19 | |
| TCGA | PKN1 | 5585 | 19 | 11 | 66 |
Total number of gains: 111; Total number of losses: 50; Total Number of normals: 327.
Somatic mutations of PKN1:
Generating mutation plots.
Highly correlated genes for PKN1:
Showing top 20/972 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKN1 | RFTN2 | 0.791248 | 3 | 0 | 3 |
| PKN1 | DHRSX | 0.759454 | 3 | 0 | 3 |
| PKN1 | FIBCD1 | 0.752484 | 3 | 0 | 3 |
| PKN1 | SNAPC2 | 0.737839 | 4 | 0 | 3 |
| PKN1 | NVL | 0.736414 | 3 | 0 | 3 |
| PKN1 | TRIM47 | 0.734323 | 3 | 0 | 3 |
| PKN1 | TBL2 | 0.730617 | 3 | 0 | 3 |
| PKN1 | SLC26A11 | 0.727185 | 3 | 0 | 3 |
| PKN1 | SETX | 0.725487 | 3 | 0 | 3 |
| PKN1 | PARVB | 0.723897 | 8 | 0 | 8 |
| PKN1 | ATP2A3 | 0.720772 | 5 | 0 | 4 |
| PKN1 | ZNF317 | 0.719683 | 4 | 0 | 4 |
| PKN1 | CYTH3 | 0.718926 | 3 | 0 | 3 |
| PKN1 | ZNF683 | 0.716283 | 3 | 0 | 3 |
| PKN1 | GNG7 | 0.715746 | 3 | 0 | 3 |
| PKN1 | ZFAND3 | 0.711238 | 4 | 0 | 3 |
| PKN1 | DDX19A | 0.709422 | 3 | 0 | 3 |
| PKN1 | PREX1 | 0.708075 | 3 | 0 | 3 |
| PKN1 | ZBTB2 | 0.707587 | 3 | 0 | 3 |
| PKN1 | ADCY3 | 0.706674 | 5 | 0 | 5 |
For details and further investigation, click here
