SETX

 

Full name: senataxin Alias Symbol: KIAA0625|AOA2|Sen1
Type: protein-coding gene Cytoband: 9q34.13
Entrez ID: 23064 HGNC ID: HGNC:445 Ensembl Gene: ENSG00000107290 OMIM ID: 608465
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SETX:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SETX 23064 201964_at -0.0662 0.9074
GSE20347 SETX 23064 201964_at -0.1892 0.2828
GSE23400 SETX 23064 201964_at 0.1241 0.0937
GSE26886 SETX 23064 201964_at -0.8805 0.0026
GSE29001 SETX 23064 201964_at 0.2012 0.3404
GSE38129 SETX 23064 201964_at -0.1289 0.4280
GSE45670 SETX 23064 201964_at 0.1365 0.3429
GSE53622 SETX 23064 15273 -0.2074 0.0066
GSE53624 SETX 23064 15273 0.0439 0.5452
GSE63941 SETX 23064 201964_at -0.7917 0.0911
GSE77861 SETX 23064 201965_s_at 0.4377 0.0665
GSE97050 SETX 23064 A_24_P940921 -0.1501 0.4780
SRP007169 SETX 23064 RNAseq 1.3291 0.0001
SRP008496 SETX 23064 RNAseq 1.2725 0.0000
SRP064894 SETX 23064 RNAseq 0.1421 0.3457
SRP133303 SETX 23064 RNAseq 0.1568 0.2484
SRP159526 SETX 23064 RNAseq -0.0642 0.7671
SRP193095 SETX 23064 RNAseq 0.0319 0.7173
SRP219564 SETX 23064 RNAseq 0.0045 0.9829
TCGA SETX 23064 RNAseq -0.0282 0.5659

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SETX expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SETX:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SETX 23064 6 7 17
GSE20123 SETX 23064 6 7 17
GSE43470 SETX 23064 4 7 32
GSE46452 SETX 23064 6 13 40
GSE47630 SETX 23064 4 15 21
GSE54993 SETX 23064 3 3 64
GSE54994 SETX 23064 12 9 32
GSE60625 SETX 23064 0 0 11
GSE74703 SETX 23064 4 5 27
GSE74704 SETX 23064 4 5 11
TCGA SETX 23064 28 26 42

Total number of gains: 77; Total number of losses: 97; Total Number of normals: 314.  

 

Somatic mutations of SETX:

 

Generating mutation plots.

 

Highly correlated genes for SETX:

 

Showing top 20/294 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SETXAP3M10.804214303
SETXARMC80.797083303
SETXSTRAP0.793084303
SETXILF20.778797303
SETXMRPS140.778598303
SETXKDM4A0.776914303
SETXGOLT1B0.768589303
SETXNBN0.760412303
SETXSEC61A10.760002303
SETXNAPG0.748168303
SETXDNAJC110.740546303
SETXSLC30A60.736797303
SETXDRAM20.736495303
SETXGIMAP10.731534303
SETXM6PR0.730451505
SETXPHB0.730228303
SETXPHF5A0.729281303
SETXZBTB330.727046303
SETXBLOC1S20.725882303
SETXPKN10.725487303

For details and further investigation, click here