| Full name: schlafen family member 11 | Alias Symbol: FLJ34922 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 91607 | HGNC ID: HGNC:26633 | Ensembl Gene: ENSG00000172716 | OMIM ID: 614953 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SLFN11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLFN11 | 91607 | 226743_at | 0.0619 | 0.9471 | |
| GSE26886 | SLFN11 | 91607 | 226743_at | 0.7032 | 0.0548 | |
| GSE45670 | SLFN11 | 91607 | 226743_at | 0.1442 | 0.7996 | |
| GSE53622 | SLFN11 | 91607 | 10322 | 0.3698 | 0.0113 | |
| GSE53624 | SLFN11 | 91607 | 10322 | 0.6685 | 0.0000 | |
| GSE63941 | SLFN11 | 91607 | 226743_at | -1.8701 | 0.2069 | |
| GSE77861 | SLFN11 | 91607 | 226743_at | 0.5364 | 0.0801 | |
| GSE97050 | SLFN11 | 91607 | A_33_P3315375 | 0.6101 | 0.1163 | |
| SRP007169 | SLFN11 | 91607 | RNAseq | 3.5107 | 0.0000 | |
| SRP008496 | SLFN11 | 91607 | RNAseq | 3.2637 | 0.0000 | |
| SRP064894 | SLFN11 | 91607 | RNAseq | 0.6315 | 0.0467 | |
| SRP133303 | SLFN11 | 91607 | RNAseq | 0.9365 | 0.0002 | |
| SRP159526 | SLFN11 | 91607 | RNAseq | 0.6486 | 0.2076 | |
| SRP193095 | SLFN11 | 91607 | RNAseq | 1.0493 | 0.0000 | |
| SRP219564 | SLFN11 | 91607 | RNAseq | 0.6621 | 0.2493 | |
| TCGA | SLFN11 | 91607 | RNAseq | 0.1263 | 0.3179 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SLFN11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLFN11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLFN11 | 91607 | 5 | 1 | 24 | |
| GSE20123 | SLFN11 | 91607 | 5 | 1 | 24 | |
| GSE43470 | SLFN11 | 91607 | 1 | 2 | 40 | |
| GSE46452 | SLFN11 | 91607 | 34 | 0 | 25 | |
| GSE47630 | SLFN11 | 91607 | 7 | 1 | 32 | |
| GSE54993 | SLFN11 | 91607 | 3 | 3 | 64 | |
| GSE54994 | SLFN11 | 91607 | 8 | 7 | 38 | |
| GSE60625 | SLFN11 | 91607 | 4 | 0 | 7 | |
| GSE74703 | SLFN11 | 91607 | 1 | 1 | 34 | |
| GSE74704 | SLFN11 | 91607 | 3 | 1 | 16 | |
| TCGA | SLFN11 | 91607 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 26; Total Number of normals: 371.
Somatic mutations of SLFN11:
Generating mutation plots.
Highly correlated genes for SLFN11:
Showing top 20/699 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLFN11 | FAM167B | 0.746633 | 3 | 0 | 3 |
| SLFN11 | CERKL | 0.746466 | 3 | 0 | 3 |
| SLFN11 | C19orf38 | 0.745696 | 3 | 0 | 3 |
| SLFN11 | FCGR3A | 0.740183 | 3 | 0 | 3 |
| SLFN11 | LMAN1 | 0.739354 | 3 | 0 | 3 |
| SLFN11 | GGT5 | 0.729086 | 4 | 0 | 4 |
| SLFN11 | AKAP5 | 0.728457 | 4 | 0 | 4 |
| SLFN11 | ATP2A3 | 0.725806 | 3 | 0 | 3 |
| SLFN11 | PLXNA1 | 0.72413 | 3 | 0 | 3 |
| SLFN11 | DDX60L | 0.720212 | 4 | 0 | 3 |
| SLFN11 | LCP2 | 0.705411 | 5 | 0 | 5 |
| SLFN11 | RAB23 | 0.704273 | 3 | 0 | 3 |
| SLFN11 | MOB3A | 0.703979 | 3 | 0 | 3 |
| SLFN11 | TLR1 | 0.697525 | 6 | 0 | 6 |
| SLFN11 | DHCR7 | 0.697204 | 3 | 0 | 3 |
| SLFN11 | TBL1XR1 | 0.694546 | 3 | 0 | 3 |
| SLFN11 | HEYL | 0.694487 | 3 | 0 | 3 |
| SLFN11 | ITGAM | 0.692857 | 6 | 0 | 6 |
| SLFN11 | HSPA13 | 0.692054 | 5 | 0 | 5 |
| SLFN11 | LRRC8C | 0.689719 | 3 | 0 | 3 |
For details and further investigation, click here
