| Full name: proline rich acidic protein 1 | Alias Symbol: UPA | ||
| Type: protein-coding gene | Cytoband: 10q26.3 | ||
| Entrez ID: 118471 | HGNC ID: HGNC:23304 | Ensembl Gene: ENSG00000165828 | OMIM ID: 609776 |
| Drug and gene relationship at DGIdb | |||
Expression of PRAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRAP1 | 118471 | 243669_s_at | -0.0916 | 0.7954 | |
| GSE26886 | PRAP1 | 118471 | 243669_s_at | -0.0717 | 0.6251 | |
| GSE45670 | PRAP1 | 118471 | 243669_s_at | -0.2121 | 0.0382 | |
| GSE53622 | PRAP1 | 118471 | 135105 | 0.2984 | 0.0013 | |
| GSE53624 | PRAP1 | 118471 | 135105 | 0.3183 | 0.0004 | |
| GSE63941 | PRAP1 | 118471 | 243669_s_at | 0.1697 | 0.3225 | |
| GSE77861 | PRAP1 | 118471 | 243669_s_at | -0.2456 | 0.0726 | |
| GSE97050 | PRAP1 | 118471 | A_33_P3260969 | -0.0090 | 0.9738 | |
| SRP133303 | PRAP1 | 118471 | RNAseq | 0.0146 | 0.9619 | |
| SRP159526 | PRAP1 | 118471 | RNAseq | 3.0722 | 0.0008 | |
| SRP219564 | PRAP1 | 118471 | RNAseq | -0.2276 | 0.6204 | |
| TCGA | PRAP1 | 118471 | RNAseq | 0.7140 | 0.2954 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PRAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRAP1 | 118471 | 3 | 8 | 19 | |
| GSE20123 | PRAP1 | 118471 | 3 | 9 | 18 | |
| GSE43470 | PRAP1 | 118471 | 0 | 8 | 35 | |
| GSE46452 | PRAP1 | 118471 | 1 | 11 | 47 | |
| GSE47630 | PRAP1 | 118471 | 4 | 13 | 23 | |
| GSE54993 | PRAP1 | 118471 | 8 | 2 | 60 | |
| GSE54994 | PRAP1 | 118471 | 1 | 9 | 43 | |
| GSE60625 | PRAP1 | 118471 | 0 | 0 | 11 | |
| GSE74703 | PRAP1 | 118471 | 0 | 6 | 30 | |
| GSE74704 | PRAP1 | 118471 | 3 | 4 | 13 | |
| TCGA | PRAP1 | 118471 | 7 | 28 | 61 |
Total number of gains: 30; Total number of losses: 98; Total Number of normals: 360.
Somatic mutations of PRAP1:
Generating mutation plots.
Highly correlated genes for PRAP1:
Showing top 20/423 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRAP1 | ANKDD1A | 0.810278 | 3 | 0 | 3 |
| PRAP1 | TMEM235 | 0.808089 | 3 | 0 | 3 |
| PRAP1 | STRC | 0.799172 | 3 | 0 | 3 |
| PRAP1 | GRIK4 | 0.791147 | 3 | 0 | 3 |
| PRAP1 | C9orf153 | 0.779055 | 3 | 0 | 3 |
| PRAP1 | GFRA4 | 0.777909 | 3 | 0 | 3 |
| PRAP1 | SPACA3 | 0.774956 | 3 | 0 | 3 |
| PRAP1 | SLC6A3 | 0.759206 | 3 | 0 | 3 |
| PRAP1 | IL1F10 | 0.745381 | 3 | 0 | 3 |
| PRAP1 | SPRED3 | 0.744817 | 3 | 0 | 3 |
| PRAP1 | C2CD4D | 0.743645 | 3 | 0 | 3 |
| PRAP1 | MRGPRG | 0.742726 | 3 | 0 | 3 |
| PRAP1 | NTNG2 | 0.74081 | 3 | 0 | 3 |
| PRAP1 | DEFB128 | 0.740068 | 3 | 0 | 3 |
| PRAP1 | ATP2B2 | 0.738042 | 3 | 0 | 3 |
| PRAP1 | LRRC10 | 0.737058 | 3 | 0 | 3 |
| PRAP1 | TSPAN10 | 0.733285 | 3 | 0 | 3 |
| PRAP1 | C19orf71 | 0.728023 | 3 | 0 | 3 |
| PRAP1 | PLA2G2C | 0.726161 | 3 | 0 | 3 |
| PRAP1 | FOXB1 | 0.72224 | 3 | 0 | 3 |
For details and further investigation, click here
