| Full name: fibrillin 3 | Alias Symbol: KIAA1776 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 84467 | HGNC ID: HGNC:18794 | Ensembl Gene: ENSG00000142449 | OMIM ID: 608529 |
| Drug and gene relationship at DGIdb | |||
Expression of FBN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBN3 | 84467 | 240117_at | 0.0280 | 0.9506 | |
| GSE26886 | FBN3 | 84467 | 240117_at | 0.2429 | 0.0173 | |
| GSE45670 | FBN3 | 84467 | 240117_at | -0.0303 | 0.7707 | |
| GSE53622 | FBN3 | 84467 | 95648 | 0.2545 | 0.2344 | |
| GSE53624 | FBN3 | 84467 | 95648 | -0.0971 | 0.6875 | |
| GSE63941 | FBN3 | 84467 | 240117_at | 0.2075 | 0.0568 | |
| GSE77861 | FBN3 | 84467 | 240117_at | -0.0028 | 0.9853 | |
| TCGA | FBN3 | 84467 | RNAseq | 1.9226 | 0.0549 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FBN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBN3 | 84467 | 4 | 3 | 23 | |
| GSE20123 | FBN3 | 84467 | 3 | 2 | 25 | |
| GSE43470 | FBN3 | 84467 | 2 | 6 | 35 | |
| GSE46452 | FBN3 | 84467 | 47 | 1 | 11 | |
| GSE47630 | FBN3 | 84467 | 5 | 7 | 28 | |
| GSE54993 | FBN3 | 84467 | 16 | 3 | 51 | |
| GSE54994 | FBN3 | 84467 | 6 | 14 | 33 | |
| GSE60625 | FBN3 | 84467 | 9 | 0 | 2 | |
| GSE74703 | FBN3 | 84467 | 2 | 4 | 30 | |
| GSE74704 | FBN3 | 84467 | 0 | 2 | 18 | |
| TCGA | FBN3 | 84467 | 10 | 20 | 66 |
Total number of gains: 104; Total number of losses: 62; Total Number of normals: 322.
Somatic mutations of FBN3:
Generating mutation plots.
Highly correlated genes for FBN3:
Showing top 20/40 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBN3 | ATP2B2 | 0.755054 | 3 | 0 | 3 |
| FBN3 | LGI2 | 0.700418 | 3 | 0 | 3 |
| FBN3 | LINC01010 | 0.685597 | 3 | 0 | 3 |
| FBN3 | WDR62 | 0.653987 | 3 | 0 | 3 |
| FBN3 | LINC01169 | 0.64007 | 3 | 0 | 3 |
| FBN3 | SLC25A42 | 0.638978 | 3 | 0 | 3 |
| FBN3 | DLK1 | 0.621063 | 4 | 0 | 3 |
| FBN3 | DNAJC5B | 0.610933 | 3 | 0 | 3 |
| FBN3 | ZFAT | 0.610197 | 4 | 0 | 3 |
| FBN3 | PTP4A3 | 0.603323 | 4 | 0 | 3 |
| FBN3 | ALX4 | 0.599762 | 3 | 0 | 3 |
| FBN3 | NR2E3 | 0.586404 | 4 | 0 | 3 |
| FBN3 | MAP3K10 | 0.583858 | 3 | 0 | 3 |
| FBN3 | SLC29A4 | 0.582075 | 3 | 0 | 3 |
| FBN3 | C19orf44 | 0.582009 | 3 | 0 | 3 |
| FBN3 | PRPH | 0.581798 | 3 | 0 | 3 |
| FBN3 | EIF3H | 0.572012 | 3 | 0 | 3 |
| FBN3 | SIGLEC7 | 0.570556 | 4 | 0 | 3 |
| FBN3 | ANKRD13B | 0.568492 | 4 | 0 | 3 |
| FBN3 | HAP1 | 0.56121 | 4 | 0 | 3 |
For details and further investigation, click here
