| Full name: ASH2 like, histone lysine methyltransferase complex subunit | Alias Symbol: ASH2L2|ASH2|Bre2 | ||
| Type: protein-coding gene | Cytoband: 8p11.23 | ||
| Entrez ID: 9070 | HGNC ID: HGNC:744 | Ensembl Gene: ENSG00000129691 | OMIM ID: 604782 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ASH2L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASH2L | 9070 | 209517_s_at | 0.1133 | 0.8494 | |
| GSE20347 | ASH2L | 9070 | 209517_s_at | 0.2533 | 0.1339 | |
| GSE23400 | ASH2L | 9070 | 209517_s_at | 0.2401 | 0.0028 | |
| GSE26886 | ASH2L | 9070 | 209517_s_at | -0.6051 | 0.0126 | |
| GSE29001 | ASH2L | 9070 | 209517_s_at | 0.3291 | 0.2819 | |
| GSE38129 | ASH2L | 9070 | 209517_s_at | 0.0982 | 0.4370 | |
| GSE45670 | ASH2L | 9070 | 209517_s_at | 0.1195 | 0.4951 | |
| GSE53622 | ASH2L | 9070 | 108371 | 0.0262 | 0.8013 | |
| GSE53624 | ASH2L | 9070 | 108371 | 0.1578 | 0.0203 | |
| GSE63941 | ASH2L | 9070 | 209517_s_at | 0.1821 | 0.6191 | |
| GSE77861 | ASH2L | 9070 | 209517_s_at | 0.1914 | 0.2081 | |
| GSE97050 | ASH2L | 9070 | A_23_P134827 | -0.1276 | 0.6525 | |
| SRP007169 | ASH2L | 9070 | RNAseq | -0.1835 | 0.6202 | |
| SRP008496 | ASH2L | 9070 | RNAseq | -0.2793 | 0.2769 | |
| SRP064894 | ASH2L | 9070 | RNAseq | 0.0842 | 0.5370 | |
| SRP133303 | ASH2L | 9070 | RNAseq | 0.1630 | 0.4206 | |
| SRP159526 | ASH2L | 9070 | RNAseq | 0.2446 | 0.5250 | |
| SRP193095 | ASH2L | 9070 | RNAseq | 0.1348 | 0.3365 | |
| SRP219564 | ASH2L | 9070 | RNAseq | -0.1603 | 0.6168 | |
| TCGA | ASH2L | 9070 | RNAseq | -0.0141 | 0.8257 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ASH2L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASH2L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASH2L | 9070 | 10 | 4 | 16 | |
| GSE20123 | ASH2L | 9070 | 11 | 4 | 15 | |
| GSE43470 | ASH2L | 9070 | 8 | 7 | 28 | |
| GSE46452 | ASH2L | 9070 | 23 | 4 | 32 | |
| GSE47630 | ASH2L | 9070 | 12 | 7 | 21 | |
| GSE54993 | ASH2L | 9070 | 2 | 16 | 52 | |
| GSE54994 | ASH2L | 9070 | 16 | 8 | 29 | |
| GSE60625 | ASH2L | 9070 | 3 | 0 | 8 | |
| GSE74703 | ASH2L | 9070 | 8 | 5 | 23 | |
| GSE74704 | ASH2L | 9070 | 9 | 1 | 10 | |
| TCGA | ASH2L | 9070 | 35 | 25 | 36 |
Total number of gains: 137; Total number of losses: 81; Total Number of normals: 270.
Somatic mutations of ASH2L:
Generating mutation plots.
Highly correlated genes for ASH2L:
Showing top 20/400 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASH2L | CLDN12 | 0.851505 | 3 | 0 | 3 |
| ASH2L | RPS6KA3 | 0.828048 | 3 | 0 | 3 |
| ASH2L | PRPF38A | 0.802014 | 3 | 0 | 3 |
| ASH2L | TET2 | 0.789334 | 3 | 0 | 3 |
| ASH2L | PARK7 | 0.778688 | 4 | 0 | 4 |
| ASH2L | TMED10 | 0.772511 | 3 | 0 | 3 |
| ASH2L | ARPC1A | 0.76624 | 3 | 0 | 3 |
| ASH2L | CNOT1 | 0.762801 | 3 | 0 | 3 |
| ASH2L | DNAJC8 | 0.759596 | 3 | 0 | 3 |
| ASH2L | NOL9 | 0.758058 | 4 | 0 | 4 |
| ASH2L | SMURF1 | 0.757765 | 3 | 0 | 3 |
| ASH2L | BABAM1 | 0.751948 | 3 | 0 | 3 |
| ASH2L | LMBRD2 | 0.751302 | 3 | 0 | 3 |
| ASH2L | COPS7A | 0.748822 | 3 | 0 | 3 |
| ASH2L | ATP8B1 | 0.748281 | 3 | 0 | 3 |
| ASH2L | PDE9A | 0.744268 | 3 | 0 | 3 |
| ASH2L | CSNK1D | 0.728398 | 3 | 0 | 3 |
| ASH2L | KIAA0556 | 0.722432 | 3 | 0 | 3 |
| ASH2L | SAE1 | 0.721636 | 4 | 0 | 4 |
| ASH2L | WDR59 | 0.720978 | 3 | 0 | 3 |
For details and further investigation, click here
