| Full name: spastin | Alias Symbol: FSP2|ADPSP|KIAA1083 | ||
| Type: protein-coding gene | Cytoband: 2p22.3 | ||
| Entrez ID: 6683 | HGNC ID: HGNC:11233 | Ensembl Gene: ENSG00000021574 | OMIM ID: 604277 |
| Drug and gene relationship at DGIdb | |||
Expression of SPAST:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPAST | 6683 | 209748_at | 0.5003 | 0.3862 | |
| GSE20347 | SPAST | 6683 | 209748_at | 0.4828 | 0.0069 | |
| GSE23400 | SPAST | 6683 | 209748_at | 0.4021 | 0.0000 | |
| GSE26886 | SPAST | 6683 | 209748_at | 0.3486 | 0.1444 | |
| GSE29001 | SPAST | 6683 | 209748_at | 0.4868 | 0.0321 | |
| GSE38129 | SPAST | 6683 | 209748_at | 0.7061 | 0.0000 | |
| GSE45670 | SPAST | 6683 | 209748_at | 0.4903 | 0.0405 | |
| GSE53622 | SPAST | 6683 | 31516 | 0.3472 | 0.0047 | |
| GSE53624 | SPAST | 6683 | 31516 | 0.2544 | 0.0083 | |
| GSE63941 | SPAST | 6683 | 207724_s_at | 1.3019 | 0.0406 | |
| GSE77861 | SPAST | 6683 | 209748_at | 1.0549 | 0.0016 | |
| GSE97050 | SPAST | 6683 | A_24_P941988 | 0.0293 | 0.9063 | |
| SRP007169 | SPAST | 6683 | RNAseq | 0.6977 | 0.1187 | |
| SRP008496 | SPAST | 6683 | RNAseq | 0.7495 | 0.0083 | |
| SRP064894 | SPAST | 6683 | RNAseq | 0.3495 | 0.0652 | |
| SRP133303 | SPAST | 6683 | RNAseq | 0.6189 | 0.0017 | |
| SRP159526 | SPAST | 6683 | RNAseq | 0.9822 | 0.0027 | |
| SRP193095 | SPAST | 6683 | RNAseq | 0.2295 | 0.0348 | |
| SRP219564 | SPAST | 6683 | RNAseq | 0.1741 | 0.5541 | |
| TCGA | SPAST | 6683 | RNAseq | 0.2822 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SPAST expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPAST:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPAST | 6683 | 10 | 1 | 19 | |
| GSE20123 | SPAST | 6683 | 9 | 1 | 20 | |
| GSE43470 | SPAST | 6683 | 2 | 1 | 40 | |
| GSE46452 | SPAST | 6683 | 2 | 4 | 53 | |
| GSE47630 | SPAST | 6683 | 8 | 0 | 32 | |
| GSE54993 | SPAST | 6683 | 0 | 5 | 65 | |
| GSE54994 | SPAST | 6683 | 10 | 1 | 42 | |
| GSE60625 | SPAST | 6683 | 0 | 3 | 8 | |
| GSE74703 | SPAST | 6683 | 2 | 0 | 34 | |
| GSE74704 | SPAST | 6683 | 9 | 1 | 10 | |
| TCGA | SPAST | 6683 | 36 | 2 | 58 |
Total number of gains: 88; Total number of losses: 19; Total Number of normals: 381.
Somatic mutations of SPAST:
Generating mutation plots.
Highly correlated genes for SPAST:
Showing top 20/1237 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPAST | FAM220A | 0.789129 | 3 | 0 | 3 |
| SPAST | ATL2 | 0.764053 | 3 | 0 | 3 |
| SPAST | ATP8B1 | 0.761312 | 3 | 0 | 3 |
| SPAST | SLC41A1 | 0.74555 | 3 | 0 | 3 |
| SPAST | TMTC1 | 0.731758 | 3 | 0 | 3 |
| SPAST | PSMG3 | 0.72985 | 3 | 0 | 3 |
| SPAST | ANKS6 | 0.727427 | 3 | 0 | 3 |
| SPAST | MTFR2 | 0.726992 | 3 | 0 | 3 |
| SPAST | SFT2D3 | 0.726027 | 6 | 0 | 5 |
| SPAST | DCAF16 | 0.725036 | 3 | 0 | 3 |
| SPAST | TPMT | 0.721886 | 3 | 0 | 3 |
| SPAST | ALG2 | 0.713982 | 3 | 0 | 3 |
| SPAST | CCAR1 | 0.712955 | 3 | 0 | 3 |
| SPAST | TMTC3 | 0.712804 | 5 | 0 | 5 |
| SPAST | LGALSL | 0.711194 | 3 | 0 | 3 |
| SPAST | CERS5 | 0.707506 | 3 | 0 | 3 |
| SPAST | WDR92 | 0.704576 | 4 | 0 | 4 |
| SPAST | TMTC4 | 0.704082 | 5 | 0 | 5 |
| SPAST | GSS | 0.703441 | 3 | 0 | 3 |
| SPAST | SSH2 | 0.700096 | 3 | 0 | 3 |
For details and further investigation, click here
