| Full name: sodium channel epithelial 1 alpha subunit | Alias Symbol: ENaCalpha | ||
| Type: protein-coding gene | Cytoband: 12p13 | ||
| Entrez ID: 6337 | HGNC ID: HGNC:10599 | Ensembl Gene: ENSG00000111319 | OMIM ID: 600228 |
| Drug and gene relationship at DGIdb | |||
SCNN1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04960 | Aldosterone-regulated sodium reabsorption |
Expression of SCNN1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCNN1A | 6337 | 203453_at | -2.1312 | 0.2366 | |
| GSE20347 | SCNN1A | 6337 | 203453_at | -2.1554 | 0.0000 | |
| GSE23400 | SCNN1A | 6337 | 203453_at | -1.9079 | 0.0000 | |
| GSE26886 | SCNN1A | 6337 | 203453_at | -2.0283 | 0.0007 | |
| GSE29001 | SCNN1A | 6337 | 203453_at | -2.3174 | 0.0029 | |
| GSE38129 | SCNN1A | 6337 | 203453_at | -1.2690 | 0.0165 | |
| GSE45670 | SCNN1A | 6337 | 203453_at | -0.9786 | 0.0662 | |
| GSE53622 | SCNN1A | 6337 | 37787 | -2.1505 | 0.0000 | |
| GSE53624 | SCNN1A | 6337 | 37787 | -2.1705 | 0.0000 | |
| GSE63941 | SCNN1A | 6337 | 203453_at | 5.0565 | 0.0031 | |
| GSE77861 | SCNN1A | 6337 | 203453_at | -1.2960 | 0.0211 | |
| GSE97050 | SCNN1A | 6337 | A_23_P128323 | 0.1388 | 0.8893 | |
| SRP007169 | SCNN1A | 6337 | RNAseq | -2.0678 | 0.0000 | |
| SRP008496 | SCNN1A | 6337 | RNAseq | -2.4258 | 0.0000 | |
| SRP064894 | SCNN1A | 6337 | RNAseq | -2.3249 | 0.0000 | |
| SRP133303 | SCNN1A | 6337 | RNAseq | -1.2858 | 0.0333 | |
| SRP159526 | SCNN1A | 6337 | RNAseq | -2.0452 | 0.0172 | |
| SRP193095 | SCNN1A | 6337 | RNAseq | -1.7629 | 0.0000 | |
| SRP219564 | SCNN1A | 6337 | RNAseq | -1.9256 | 0.0569 | |
| TCGA | SCNN1A | 6337 | RNAseq | -0.2445 | 0.2608 |
Upregulated datasets: 1; Downregulated datasets: 14.
Survival by SCNN1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCNN1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCNN1A | 6337 | 9 | 3 | 18 | |
| GSE20123 | SCNN1A | 6337 | 9 | 3 | 18 | |
| GSE43470 | SCNN1A | 6337 | 8 | 3 | 32 | |
| GSE46452 | SCNN1A | 6337 | 10 | 1 | 48 | |
| GSE47630 | SCNN1A | 6337 | 12 | 2 | 26 | |
| GSE54993 | SCNN1A | 6337 | 1 | 10 | 59 | |
| GSE54994 | SCNN1A | 6337 | 10 | 2 | 41 | |
| GSE60625 | SCNN1A | 6337 | 0 | 1 | 10 | |
| GSE74703 | SCNN1A | 6337 | 7 | 2 | 27 | |
| GSE74704 | SCNN1A | 6337 | 5 | 2 | 13 | |
| TCGA | SCNN1A | 6337 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 35; Total Number of normals: 342.
Somatic mutations of SCNN1A:
Generating mutation plots.
Highly correlated genes for SCNN1A:
Showing top 20/1003 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCNN1A | ELF3 | 0.785979 | 13 | 0 | 13 |
| SCNN1A | ERBB3 | 0.777872 | 12 | 0 | 12 |
| SCNN1A | TMPRSS11A | 0.775215 | 3 | 0 | 3 |
| SCNN1A | NCCRP1 | 0.772128 | 3 | 0 | 3 |
| SCNN1A | MGST2 | 0.770827 | 10 | 0 | 10 |
| SCNN1A | NEBL | 0.767119 | 13 | 0 | 12 |
| SCNN1A | PPL | 0.760249 | 12 | 0 | 12 |
| SCNN1A | CEACAM7 | 0.758113 | 11 | 0 | 11 |
| SCNN1A | CLDN4 | 0.756325 | 10 | 0 | 10 |
| SCNN1A | EVPL | 0.753549 | 12 | 0 | 12 |
| SCNN1A | KLK13 | 0.751759 | 11 | 0 | 10 |
| SCNN1A | CEACAM5 | 0.751658 | 13 | 0 | 12 |
| SCNN1A | MAL2 | 0.746083 | 7 | 0 | 7 |
| SCNN1A | SCNN1B | 0.745787 | 11 | 0 | 11 |
| SCNN1A | ULK3 | 0.7442 | 6 | 0 | 6 |
| SCNN1A | FAM214A | 0.74283 | 6 | 0 | 6 |
| SCNN1A | LIPH | 0.739723 | 8 | 0 | 8 |
| SCNN1A | EPHX3 | 0.737519 | 11 | 0 | 11 |
| SCNN1A | MUC20 | 0.737082 | 8 | 0 | 7 |
| SCNN1A | UPK3B | 0.737035 | 3 | 0 | 3 |
For details and further investigation, click here
