BRIP1

 

Full name: BRCA1 interacting protein C-terminal helicase 1 Alias Symbol: OF|BACH1|FANCJ
Type: protein-coding gene Cytoband: 17q23.2
Entrez ID: 83990 HGNC ID: HGNC:20473 Ensembl Gene: ENSG00000136492 OMIM ID: 605882
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

BRIP1 involved pathways:

KEGG pathway Description View
hsa03460Fanconi anemia pathway

 

Expression of BRIP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BRIP1 83990 235609_at 1.2341 0.1306
GSE20347 BRIP1 83990 221703_at 0.1960 0.0048
GSE23400 BRIP1 83990 221703_at 0.1501 0.0000
GSE26886 BRIP1 83990 235609_at 1.3511 0.0001
GSE29001 BRIP1 83990 221703_at 0.2120 0.0716
GSE38129 BRIP1 83990 221703_at 0.2696 0.0000
GSE45670 BRIP1 83990 235609_at 0.8796 0.0013
GSE53622 BRIP1 83990 90886 1.5843 0.0000
GSE53624 BRIP1 83990 90886 1.6831 0.0000
GSE63941 BRIP1 83990 235609_at 1.6711 0.0279
GSE77861 BRIP1 83990 235609_at 0.5439 0.0198
GSE97050 BRIP1 83990 A_23_P15844 0.7231 0.0969
SRP007169 BRIP1 83990 RNAseq 1.5658 0.0003
SRP008496 BRIP1 83990 RNAseq 1.7139 0.0000
SRP064894 BRIP1 83990 RNAseq 1.0845 0.0004
SRP133303 BRIP1 83990 RNAseq 0.9963 0.0003
SRP159526 BRIP1 83990 RNAseq 1.1905 0.0036
SRP193095 BRIP1 83990 RNAseq 0.5406 0.0000
SRP219564 BRIP1 83990 RNAseq 0.9809 0.0877
TCGA BRIP1 83990 RNAseq 1.2069 0.0000

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by BRIP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BRIP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BRIP1 83990 4 1 25
GSE20123 BRIP1 83990 4 1 25
GSE43470 BRIP1 83990 5 0 38
GSE46452 BRIP1 83990 31 0 28
GSE47630 BRIP1 83990 7 1 32
GSE54993 BRIP1 83990 2 5 63
GSE54994 BRIP1 83990 9 5 39
GSE60625 BRIP1 83990 4 0 7
GSE74703 BRIP1 83990 5 0 31
GSE74704 BRIP1 83990 3 1 16
TCGA BRIP1 83990 31 6 59

Total number of gains: 105; Total number of losses: 20; Total Number of normals: 363.  

 

Somatic mutations of BRIP1:

 

Generating mutation plots.

 

Highly correlated genes for BRIP1:

 

Showing top 20/1107 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BRIP1UBE2T0.806073808
BRIP1MTFR20.774685707
BRIP1TRPV40.764485303
BRIP1CDCA50.764477707
BRIP1KIF140.76344412011
BRIP1CKAP2L0.758693808
BRIP1CENPW0.757807808
BRIP1MMS22L0.754874303
BRIP1SPAG50.75400912011
BRIP1CENPF0.74604212012
BRIP1TIMELESS0.74183612012
BRIP1ASPM0.74036112011
BRIP1ECT20.74035112012
BRIP1FOXM10.74034412012
BRIP1CDK10.73960712012
BRIP1TTK0.73937612011
BRIP1NCAPH0.739176909
BRIP1BUB1B0.735795908
BRIP1KNSTRN0.734158707
BRIP1CDC450.73334512012

For details and further investigation, click here