| Full name: heat shock protein family B (small) member 3 | Alias Symbol: HSPL27 | ||
| Type: protein-coding gene | Cytoband: 5q11.2 | ||
| Entrez ID: 8988 | HGNC ID: HGNC:5248 | Ensembl Gene: ENSG00000169271 | OMIM ID: 604624 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HSPB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSPB3 | 8988 | 206375_s_at | -1.1376 | 0.3549 | |
| GSE20347 | HSPB3 | 8988 | 206375_s_at | 0.2732 | 0.4220 | |
| GSE23400 | HSPB3 | 8988 | 206375_s_at | -0.1287 | 0.2054 | |
| GSE26886 | HSPB3 | 8988 | 206375_s_at | 0.8405 | 0.0001 | |
| GSE29001 | HSPB3 | 8988 | 206375_s_at | 0.2170 | 0.6789 | |
| GSE38129 | HSPB3 | 8988 | 206375_s_at | -0.3014 | 0.4583 | |
| GSE45670 | HSPB3 | 8988 | 206375_s_at | -0.1919 | 0.7948 | |
| GSE53622 | HSPB3 | 8988 | 50980 | -0.2705 | 0.2885 | |
| GSE53624 | HSPB3 | 8988 | 50980 | -0.2997 | 0.1732 | |
| GSE63941 | HSPB3 | 8988 | 206375_s_at | 0.8164 | 0.4889 | |
| GSE77861 | HSPB3 | 8988 | 206375_s_at | 0.4587 | 0.3417 | |
| GSE97050 | HSPB3 | 8988 | A_23_P92730 | -1.4361 | 0.2171 | |
| SRP159526 | HSPB3 | 8988 | RNAseq | -0.5413 | 0.4003 | |
| SRP219564 | HSPB3 | 8988 | RNAseq | -0.7704 | 0.3529 | |
| TCGA | HSPB3 | 8988 | RNAseq | 0.0919 | 0.8688 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSPB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPB3 | 8988 | 1 | 13 | 16 | |
| GSE20123 | HSPB3 | 8988 | 1 | 13 | 16 | |
| GSE43470 | HSPB3 | 8988 | 1 | 12 | 30 | |
| GSE46452 | HSPB3 | 8988 | 1 | 27 | 31 | |
| GSE47630 | HSPB3 | 8988 | 2 | 16 | 22 | |
| GSE54993 | HSPB3 | 8988 | 8 | 1 | 61 | |
| GSE54994 | HSPB3 | 8988 | 5 | 18 | 30 | |
| GSE60625 | HSPB3 | 8988 | 0 | 0 | 11 | |
| GSE74703 | HSPB3 | 8988 | 1 | 9 | 26 | |
| GSE74704 | HSPB3 | 8988 | 1 | 6 | 13 | |
| TCGA | HSPB3 | 8988 | 8 | 45 | 43 |
Total number of gains: 29; Total number of losses: 160; Total Number of normals: 299.
Somatic mutations of HSPB3:
Generating mutation plots.
Highly correlated genes for HSPB3:
Showing top 20/268 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPB3 | SOX8 | 0.721449 | 3 | 0 | 3 |
| HSPB3 | STK33 | 0.701808 | 3 | 0 | 3 |
| HSPB3 | GABRA5 | 0.697051 | 4 | 0 | 3 |
| HSPB3 | ROR2 | 0.685599 | 3 | 0 | 3 |
| HSPB3 | CITED1 | 0.682382 | 4 | 0 | 4 |
| HSPB3 | COL16A1 | 0.681523 | 3 | 0 | 3 |
| HSPB3 | RNF150 | 0.67959 | 4 | 0 | 4 |
| HSPB3 | ST8SIA1 | 0.67393 | 4 | 0 | 3 |
| HSPB3 | LMO1 | 0.673826 | 4 | 0 | 4 |
| HSPB3 | KITLG | 0.666486 | 4 | 0 | 3 |
| HSPB3 | AXIN2 | 0.657398 | 3 | 0 | 3 |
| HSPB3 | MYADM | 0.653665 | 5 | 0 | 3 |
| HSPB3 | TWIST2 | 0.651038 | 4 | 0 | 3 |
| HSPB3 | ACTN2 | 0.650204 | 5 | 0 | 4 |
| HSPB3 | SHISA3 | 0.649957 | 3 | 0 | 3 |
| HSPB3 | CCDC8 | 0.649438 | 4 | 0 | 3 |
| HSPB3 | DLC1 | 0.647659 | 6 | 0 | 5 |
| HSPB3 | CORO6 | 0.647095 | 4 | 0 | 3 |
| HSPB3 | SHISA4 | 0.644749 | 3 | 0 | 3 |
| HSPB3 | LINC00888 | 0.644036 | 3 | 0 | 3 |
For details and further investigation, click here
