| Full name: derlin 1 | Alias Symbol: MGC3067|PRO2577|FLJ13784|DER1|DER-1|derlin-1 | ||
| Type: protein-coding gene | Cytoband: 8q24.13 | ||
| Entrez ID: 79139 | HGNC ID: HGNC:28454 | Ensembl Gene: ENSG00000136986 | OMIM ID: 608813 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DERL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of DERL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DERL1 | 79139 | 219402_s_at | 0.6804 | 0.1723 | |
| GSE20347 | DERL1 | 79139 | 219402_s_at | 0.4309 | 0.0273 | |
| GSE23400 | DERL1 | 79139 | 219402_s_at | 0.6806 | 0.0000 | |
| GSE26886 | DERL1 | 79139 | 219402_s_at | 0.7310 | 0.0000 | |
| GSE29001 | DERL1 | 79139 | 219402_s_at | 0.4045 | 0.1248 | |
| GSE38129 | DERL1 | 79139 | 219402_s_at | 0.7318 | 0.0001 | |
| GSE45670 | DERL1 | 79139 | 222543_at | 0.6013 | 0.0002 | |
| GSE63941 | DERL1 | 79139 | 219402_s_at | 1.2584 | 0.0058 | |
| GSE77861 | DERL1 | 79139 | 219402_s_at | 0.2558 | 0.3452 | |
| GSE97050 | DERL1 | 79139 | A_23_P330908 | 0.4874 | 0.1061 | |
| SRP007169 | DERL1 | 79139 | RNAseq | 0.6438 | 0.0710 | |
| SRP008496 | DERL1 | 79139 | RNAseq | 0.6744 | 0.0109 | |
| SRP064894 | DERL1 | 79139 | RNAseq | 1.0905 | 0.0000 | |
| SRP133303 | DERL1 | 79139 | RNAseq | 0.8865 | 0.0000 | |
| SRP159526 | DERL1 | 79139 | RNAseq | 0.3930 | 0.0822 | |
| SRP193095 | DERL1 | 79139 | RNAseq | 0.4778 | 0.0002 | |
| SRP219564 | DERL1 | 79139 | RNAseq | 0.7930 | 0.0341 | |
| TCGA | DERL1 | 79139 | RNAseq | 0.1426 | 0.0019 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DERL1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DERL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DERL1 | 79139 | 19 | 1 | 10 | |
| GSE20123 | DERL1 | 79139 | 20 | 1 | 9 | |
| GSE43470 | DERL1 | 79139 | 22 | 0 | 21 | |
| GSE46452 | DERL1 | 79139 | 27 | 0 | 32 | |
| GSE47630 | DERL1 | 79139 | 24 | 0 | 16 | |
| GSE54993 | DERL1 | 79139 | 0 | 21 | 49 | |
| GSE54994 | DERL1 | 79139 | 37 | 1 | 15 | |
| GSE60625 | DERL1 | 79139 | 0 | 4 | 7 | |
| GSE74703 | DERL1 | 79139 | 19 | 0 | 17 | |
| GSE74704 | DERL1 | 79139 | 13 | 1 | 6 | |
| TCGA | DERL1 | 79139 | 67 | 1 | 28 |
Total number of gains: 248; Total number of losses: 30; Total Number of normals: 210.
Somatic mutations of DERL1:
Generating mutation plots.
Highly correlated genes for DERL1:
Showing top 20/1518 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DERL1 | B3GALT6 | 0.826065 | 4 | 0 | 4 |
| DERL1 | ELOF1 | 0.781766 | 3 | 0 | 3 |
| DERL1 | NUS1 | 0.778086 | 3 | 0 | 3 |
| DERL1 | CXCL16 | 0.776221 | 3 | 0 | 3 |
| DERL1 | YWHAG | 0.771966 | 3 | 0 | 3 |
| DERL1 | PDE7A | 0.758809 | 4 | 0 | 4 |
| DERL1 | CEP250 | 0.752736 | 3 | 0 | 3 |
| DERL1 | FTO | 0.749483 | 3 | 0 | 3 |
| DERL1 | GTPBP6 | 0.74732 | 3 | 0 | 3 |
| DERL1 | ZNF579 | 0.745946 | 3 | 0 | 3 |
| DERL1 | BRAT1 | 0.744423 | 4 | 0 | 4 |
| DERL1 | XAB2 | 0.743277 | 3 | 0 | 3 |
| DERL1 | TPM3 | 0.738634 | 4 | 0 | 4 |
| DERL1 | NEK6 | 0.735473 | 4 | 0 | 4 |
| DERL1 | SERPINF2 | 0.734319 | 3 | 0 | 3 |
| DERL1 | HELB | 0.732001 | 3 | 0 | 3 |
| DERL1 | XXYLT1 | 0.731971 | 5 | 0 | 4 |
| DERL1 | CCM2 | 0.730437 | 5 | 0 | 5 |
| DERL1 | GRAMD4 | 0.7299 | 3 | 0 | 3 |
| DERL1 | PPHLN1 | 0.727408 | 3 | 0 | 3 |
For details and further investigation, click here
