DCAF13

 

Full name: DDB1 and CUL4 associated factor 13 Alias Symbol: DKFZP564O0463|Gm83|HSPC064|Sof1
Type: protein-coding gene Cytoband: 8q22.3
Entrez ID: 25879 HGNC ID: HGNC:24535 Ensembl Gene: ENSG00000164934 OMIM ID: 616196
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of DCAF13:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DCAF13 25879 225676_s_at 1.2259 0.0602
GSE20347 DCAF13 25879 220843_s_at 0.3617 0.0067
GSE23400 DCAF13 25879 220843_s_at -0.0375 0.1704
GSE26886 DCAF13 25879 225676_s_at 0.1640 0.4971
GSE29001 DCAF13 25879 220843_s_at 0.3191 0.0945
GSE38129 DCAF13 25879 220843_s_at 0.3571 0.0011
GSE45670 DCAF13 25879 225676_s_at 0.7995 0.0002
GSE53622 DCAF13 25879 71306 0.9391 0.0000
GSE53624 DCAF13 25879 71306 1.1203 0.0000
GSE63941 DCAF13 25879 225676_s_at 0.3541 0.5182
GSE77861 DCAF13 25879 225676_s_at 0.5961 0.0388
GSE97050 DCAF13 25879 A_23_P215875 1.2972 0.0555
SRP007169 DCAF13 25879 RNAseq 0.2544 0.4506
SRP008496 DCAF13 25879 RNAseq 0.4722 0.0631
SRP064894 DCAF13 25879 RNAseq 1.0486 0.0000
SRP133303 DCAF13 25879 RNAseq 0.8106 0.0000
SRP159526 DCAF13 25879 RNAseq 0.5515 0.1477
SRP193095 DCAF13 25879 RNAseq 0.3679 0.0303
SRP219564 DCAF13 25879 RNAseq 0.7772 0.0651
TCGA DCAF13 25879 RNAseq 0.3582 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by DCAF13 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DCAF13:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DCAF13 25879 16 0 14
GSE20123 DCAF13 25879 18 0 12
GSE43470 DCAF13 25879 22 0 21
GSE46452 DCAF13 25879 24 0 35
GSE47630 DCAF13 25879 24 0 16
GSE54993 DCAF13 25879 0 20 50
GSE54994 DCAF13 25879 37 1 15
GSE60625 DCAF13 25879 0 4 7
GSE74703 DCAF13 25879 19 0 17
GSE74704 DCAF13 25879 11 0 9
TCGA DCAF13 25879 60 1 35

Total number of gains: 231; Total number of losses: 26; Total Number of normals: 231.  

 

Somatic mutations of DCAF13:

 

Generating mutation plots.

 

Highly correlated genes for DCAF13:

 

Showing top 20/2065 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DCAF13EBNA1BP20.844896303
DCAF13ILF20.832686606
DCAF13NUF20.815995606
DCAF13CDCA20.810562404
DCAF13NOP560.807602303
DCAF13ZNF7070.801214303
DCAF13DKC10.792192303
DCAF13B3GALT60.788112505
DCAF13UCK20.784645303
DCAF13UBE2T0.779769606
DCAF13PTK70.775076606
DCAF13ANLN0.773409606
DCAF13WDR540.772349505
DCAF13CTHRC10.770241606
DCAF13FAM89A0.76917303
DCAF13MAP4K40.760222303
DCAF13DNAJB110.759833706
DCAF13EFTUD20.757205606
DCAF13LRRC590.756524303
DCAF13ANAPC10.75565303

For details and further investigation, click here