| Full name: RNA polymerase II subunit K | Alias Symbol: RPB10alpha | ||
| Type: protein-coding gene | Cytoband: 8q22.2 | ||
| Entrez ID: 5440 | HGNC ID: HGNC:9198 | Ensembl Gene: ENSG00000147669 | OMIM ID: 606033 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR2K:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR2K | 5440 | 202635_s_at | 0.8192 | 0.0366 | |
| GSE20347 | POLR2K | 5440 | 202635_s_at | 1.0300 | 0.0000 | |
| GSE23400 | POLR2K | 5440 | 202635_s_at | 1.0448 | 0.0000 | |
| GSE26886 | POLR2K | 5440 | 202634_at | 0.5239 | 0.0092 | |
| GSE29001 | POLR2K | 5440 | 202634_at | 0.5760 | 0.0326 | |
| GSE38129 | POLR2K | 5440 | 202635_s_at | 0.8822 | 0.0000 | |
| GSE45670 | POLR2K | 5440 | 202635_s_at | 0.4134 | 0.0075 | |
| GSE63941 | POLR2K | 5440 | 202635_s_at | 0.5907 | 0.1298 | |
| GSE77861 | POLR2K | 5440 | 202635_s_at | 0.2792 | 0.3412 | |
| GSE97050 | POLR2K | 5440 | A_23_P157449 | -0.1476 | 0.6255 | |
| SRP007169 | POLR2K | 5440 | RNAseq | -0.0022 | 0.9945 | |
| SRP008496 | POLR2K | 5440 | RNAseq | 0.2713 | 0.3030 | |
| SRP064894 | POLR2K | 5440 | RNAseq | 0.7217 | 0.0011 | |
| SRP133303 | POLR2K | 5440 | RNAseq | 0.6321 | 0.0001 | |
| SRP159526 | POLR2K | 5440 | RNAseq | 0.4192 | 0.0164 | |
| SRP193095 | POLR2K | 5440 | RNAseq | 0.1893 | 0.2315 | |
| SRP219564 | POLR2K | 5440 | RNAseq | 0.2040 | 0.5118 | |
| TCGA | POLR2K | 5440 | RNAseq | 0.1564 | 0.0045 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by POLR2K expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of POLR2K:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR2K | 5440 | 17 | 0 | 13 | |
| GSE20123 | POLR2K | 5440 | 17 | 0 | 13 | |
| GSE43470 | POLR2K | 5440 | 21 | 0 | 22 | |
| GSE46452 | POLR2K | 5440 | 24 | 0 | 35 | |
| GSE47630 | POLR2K | 5440 | 24 | 0 | 16 | |
| GSE54993 | POLR2K | 5440 | 0 | 20 | 50 | |
| GSE54994 | POLR2K | 5440 | 38 | 1 | 14 | |
| GSE60625 | POLR2K | 5440 | 0 | 4 | 7 | |
| GSE74703 | POLR2K | 5440 | 18 | 0 | 18 | |
| GSE74704 | POLR2K | 5440 | 12 | 0 | 8 | |
| TCGA | POLR2K | 5440 | 58 | 1 | 37 |
Total number of gains: 229; Total number of losses: 26; Total Number of normals: 233.
Somatic mutations of POLR2K:
Generating mutation plots.
Highly correlated genes for POLR2K:
Showing top 20/1600 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR2K | CCDC127 | 0.834653 | 3 | 0 | 3 |
| POLR2K | TP53RK | 0.820977 | 3 | 0 | 3 |
| POLR2K | KLHL8 | 0.820212 | 3 | 0 | 3 |
| POLR2K | WDR5 | 0.813562 | 3 | 0 | 3 |
| POLR2K | ZNF496 | 0.800886 | 3 | 0 | 3 |
| POLR2K | ATP6V1C1 | 0.796033 | 11 | 0 | 11 |
| POLR2K | BCORL1 | 0.79557 | 3 | 0 | 3 |
| POLR2K | B3GALT6 | 0.789663 | 4 | 0 | 4 |
| POLR2K | ENY2 | 0.781438 | 11 | 0 | 10 |
| POLR2K | DNAH14 | 0.778959 | 3 | 0 | 3 |
| POLR2K | MTERF3 | 0.777329 | 8 | 0 | 8 |
| POLR2K | SS18L1 | 0.773593 | 3 | 0 | 3 |
| POLR2K | SLC7A6OS | 0.768775 | 3 | 0 | 3 |
| POLR2K | NAF1 | 0.767157 | 4 | 0 | 4 |
| POLR2K | ZNF284 | 0.762006 | 3 | 0 | 3 |
| POLR2K | SOCS4 | 0.758772 | 4 | 0 | 4 |
| POLR2K | BLCAP | 0.756963 | 3 | 0 | 3 |
| POLR2K | PPP1R16A | 0.754763 | 4 | 0 | 4 |
| POLR2K | TIA1 | 0.753203 | 3 | 0 | 3 |
| POLR2K | MRPL13 | 0.751079 | 10 | 0 | 9 |
For details and further investigation, click here
