DNMT1

 

Full name: DNA methyltransferase 1 Alias Symbol: MCMT|CXXC9
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 1786 HGNC ID: HGNC:2976 Ensembl Gene: ENSG00000130816 OMIM ID: 126375
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DNMT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DNMT1 1786 201697_s_at 1.0767 0.0276
GSE20347 DNMT1 1786 201697_s_at 1.1610 0.0000
GSE23400 DNMT1 1786 201697_s_at 1.2302 0.0000
GSE26886 DNMT1 1786 201697_s_at 1.3502 0.0000
GSE29001 DNMT1 1786 201697_s_at 1.1550 0.0002
GSE38129 DNMT1 1786 201697_s_at 1.2316 0.0000
GSE45670 DNMT1 1786 201697_s_at 0.8461 0.0001
GSE53622 DNMT1 1786 41738 1.0634 0.0000
GSE53624 DNMT1 1786 41738 1.2499 0.0000
GSE63941 DNMT1 1786 201697_s_at 1.1617 0.0099
GSE77861 DNMT1 1786 201697_s_at 1.0395 0.0023
GSE97050 DNMT1 1786 A_33_P3329187 1.0694 0.0782
SRP007169 DNMT1 1786 RNAseq 2.4344 0.0000
SRP008496 DNMT1 1786 RNAseq 1.9506 0.0000
SRP064894 DNMT1 1786 RNAseq 1.2000 0.0000
SRP133303 DNMT1 1786 RNAseq 0.9680 0.0000
SRP159526 DNMT1 1786 RNAseq 0.8714 0.0066
SRP193095 DNMT1 1786 RNAseq 0.9502 0.0000
SRP219564 DNMT1 1786 RNAseq 2.1298 0.0017
TCGA DNMT1 1786 RNAseq 0.3939 0.0000

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by DNMT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DNMT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DNMT1 1786 4 2 24
GSE20123 DNMT1 1786 3 1 26
GSE43470 DNMT1 1786 3 6 34
GSE46452 DNMT1 1786 47 1 11
GSE47630 DNMT1 1786 4 7 29
GSE54993 DNMT1 1786 16 3 51
GSE54994 DNMT1 1786 7 13 33
GSE60625 DNMT1 1786 9 0 2
GSE74703 DNMT1 1786 3 4 29
GSE74704 DNMT1 1786 0 1 19
TCGA DNMT1 1786 13 16 67

Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.  

 

Somatic mutations of DNMT1:

 

Generating mutation plots.

 

Highly correlated genes for DNMT1:

 

Showing top 20/2463 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DNMT1COLGALT10.84003710010
DNMT1UBE2T0.839057808
DNMT1SIX40.828088707
DNMT1MCM60.8250613013
DNMT1MYBL20.82336512012
DNMT1BUB10.82274810010
DNMT1CD2760.821334404
DNMT1TIMELESS0.81756413012
DNMT1CDCA20.817259606
DNMT1PLXNA10.81615911011
DNMT1NCAPG20.81585911011
DNMT1MCM20.81333712011
DNMT1KIF2C0.81333112011
DNMT1UBE2C0.81266213012
DNMT1MARCKSL10.8105511011
DNMT1DTL0.81053313012
DNMT1TPX20.80851313012
DNMT1MCM30.80837712012
DNMT1ACLY0.80761111011
DNMT1CENPF0.80644813012

For details and further investigation, click here