| Full name: origin recognition complex subunit 3 | Alias Symbol: IMAGE50150|LATHEO | ||
| Type: protein-coding gene | Cytoband: 6q15 | ||
| Entrez ID: 23595 | HGNC ID: HGNC:8489 | Ensembl Gene: ENSG00000135336 | OMIM ID: 604972 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ORC3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of ORC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORC3 | 23595 | 210028_s_at | 0.0715 | 0.8683 | |
| GSE20347 | ORC3 | 23595 | 210028_s_at | 0.5994 | 0.0009 | |
| GSE23400 | ORC3 | 23595 | 210028_s_at | 0.4441 | 0.0000 | |
| GSE26886 | ORC3 | 23595 | 210028_s_at | 0.9516 | 0.0000 | |
| GSE29001 | ORC3 | 23595 | 210028_s_at | 0.7713 | 0.0079 | |
| GSE38129 | ORC3 | 23595 | 210028_s_at | 0.5188 | 0.0000 | |
| GSE45670 | ORC3 | 23595 | 210028_s_at | 0.2984 | 0.0561 | |
| GSE53622 | ORC3 | 23595 | 14388 | 0.6732 | 0.0000 | |
| GSE53624 | ORC3 | 23595 | 14388 | 0.7294 | 0.0000 | |
| GSE63941 | ORC3 | 23595 | 210028_s_at | -0.3702 | 0.4741 | |
| GSE77861 | ORC3 | 23595 | 210028_s_at | 0.7210 | 0.0067 | |
| GSE97050 | ORC3 | 23595 | A_23_P42045 | 0.2859 | 0.2539 | |
| SRP007169 | ORC3 | 23595 | RNAseq | 1.4722 | 0.0013 | |
| SRP008496 | ORC3 | 23595 | RNAseq | 1.1514 | 0.0000 | |
| SRP064894 | ORC3 | 23595 | RNAseq | 0.5712 | 0.0022 | |
| SRP133303 | ORC3 | 23595 | RNAseq | 0.4631 | 0.0090 | |
| SRP159526 | ORC3 | 23595 | RNAseq | 0.4659 | 0.0152 | |
| SRP193095 | ORC3 | 23595 | RNAseq | 0.2874 | 0.0080 | |
| SRP219564 | ORC3 | 23595 | RNAseq | 0.4673 | 0.2757 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ORC3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ORC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORC3 | 23595 | 1 | 4 | 25 | |
| GSE20123 | ORC3 | 23595 | 1 | 3 | 26 | |
| GSE43470 | ORC3 | 23595 | 3 | 1 | 39 | |
| GSE46452 | ORC3 | 23595 | 2 | 11 | 46 | |
| GSE47630 | ORC3 | 23595 | 8 | 6 | 26 | |
| GSE54993 | ORC3 | 23595 | 3 | 2 | 65 | |
| GSE54994 | ORC3 | 23595 | 8 | 8 | 37 | |
| GSE60625 | ORC3 | 23595 | 0 | 1 | 10 | |
| GSE74703 | ORC3 | 23595 | 3 | 1 | 32 | |
| GSE74704 | ORC3 | 23595 | 0 | 2 | 18 | |
| TCGA | ORC3 | 23595 | 5 | 21 | 70 |
Total number of gains: 34; Total number of losses: 60; Total Number of normals: 394.
Somatic mutations of ORC3:
Generating mutation plots.
Highly correlated genes for ORC3:
Showing top 20/1574 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORC3 | B3GALT6 | 0.76921 | 4 | 0 | 4 |
| ORC3 | MMS22L | 0.762736 | 3 | 0 | 3 |
| ORC3 | MCM6 | 0.75676 | 10 | 0 | 10 |
| ORC3 | XPO1 | 0.745759 | 9 | 0 | 9 |
| ORC3 | SNAP47 | 0.73862 | 3 | 0 | 3 |
| ORC3 | MCM3 | 0.736565 | 9 | 0 | 9 |
| ORC3 | DHRSX | 0.736384 | 3 | 0 | 3 |
| ORC3 | RFC4 | 0.73026 | 10 | 0 | 10 |
| ORC3 | PYCR2 | 0.726173 | 3 | 0 | 3 |
| ORC3 | CASP8AP2 | 0.722915 | 11 | 0 | 10 |
| ORC3 | NF1 | 0.721927 | 3 | 0 | 3 |
| ORC3 | SLC35B2 | 0.720387 | 3 | 0 | 3 |
| ORC3 | ZNF622 | 0.719175 | 3 | 0 | 3 |
| ORC3 | MSH6 | 0.718889 | 10 | 0 | 9 |
| ORC3 | MINPP1 | 0.71778 | 10 | 0 | 10 |
| ORC3 | ACTL6A | 0.716077 | 10 | 0 | 9 |
| ORC3 | CMSS1 | 0.713008 | 5 | 0 | 5 |
| ORC3 | PPT1 | 0.712563 | 10 | 0 | 9 |
| ORC3 | MRPL52 | 0.707986 | 3 | 0 | 3 |
| ORC3 | SIX4 | 0.70722 | 6 | 0 | 5 |
For details and further investigation, click here
