| Full name: beta-secretase 2 | Alias Symbol: CEAP1|DRAP|ALP56 | ||
| Type: protein-coding gene | Cytoband: 21q22.2-q22.3 | ||
| Entrez ID: 25825 | HGNC ID: HGNC:934 | Ensembl Gene: ENSG00000182240 | OMIM ID: 605668 |
| Drug and gene relationship at DGIdb | |||
Expression of BACE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BACE2 | 25825 | 222446_s_at | -0.1505 | 0.8202 | |
| GSE20347 | BACE2 | 25825 | 217867_x_at | -0.6894 | 0.0017 | |
| GSE23400 | BACE2 | 25825 | 217867_x_at | -0.4616 | 0.0000 | |
| GSE26886 | BACE2 | 25825 | 222446_s_at | -0.6580 | 0.0113 | |
| GSE29001 | BACE2 | 25825 | 217867_x_at | -0.4634 | 0.2163 | |
| GSE38129 | BACE2 | 25825 | 217867_x_at | -0.3994 | 0.0754 | |
| GSE45670 | BACE2 | 25825 | 222446_s_at | -0.2343 | 0.2558 | |
| GSE53622 | BACE2 | 25825 | 77740 | -0.3101 | 0.0000 | |
| GSE53624 | BACE2 | 25825 | 68632 | -0.5568 | 0.0000 | |
| GSE63941 | BACE2 | 25825 | 222446_s_at | -0.1580 | 0.8800 | |
| GSE77861 | BACE2 | 25825 | 222446_s_at | -0.6515 | 0.0276 | |
| GSE97050 | BACE2 | 25825 | A_23_P154875 | 0.0873 | 0.8337 | |
| SRP007169 | BACE2 | 25825 | RNAseq | -2.3482 | 0.0000 | |
| SRP008496 | BACE2 | 25825 | RNAseq | -1.8388 | 0.0000 | |
| SRP064894 | BACE2 | 25825 | RNAseq | -0.6249 | 0.0193 | |
| SRP133303 | BACE2 | 25825 | RNAseq | -0.4591 | 0.0107 | |
| SRP159526 | BACE2 | 25825 | RNAseq | -0.5121 | 0.0091 | |
| SRP193095 | BACE2 | 25825 | RNAseq | -0.4300 | 0.0661 | |
| SRP219564 | BACE2 | 25825 | RNAseq | 0.0721 | 0.7968 | |
| TCGA | BACE2 | 25825 | RNAseq | -0.2768 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by BACE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BACE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BACE2 | 25825 | 2 | 9 | 19 | |
| GSE20123 | BACE2 | 25825 | 2 | 9 | 19 | |
| GSE43470 | BACE2 | 25825 | 0 | 13 | 30 | |
| GSE46452 | BACE2 | 25825 | 1 | 21 | 37 | |
| GSE47630 | BACE2 | 25825 | 6 | 17 | 17 | |
| GSE54993 | BACE2 | 25825 | 8 | 1 | 61 | |
| GSE54994 | BACE2 | 25825 | 3 | 8 | 42 | |
| GSE60625 | BACE2 | 25825 | 0 | 0 | 11 | |
| GSE74703 | BACE2 | 25825 | 0 | 10 | 26 | |
| GSE74704 | BACE2 | 25825 | 1 | 5 | 14 | |
| TCGA | BACE2 | 25825 | 7 | 41 | 48 |
Total number of gains: 30; Total number of losses: 134; Total Number of normals: 324.
Somatic mutations of BACE2:
Generating mutation plots.
Highly correlated genes for BACE2:
Showing top 20/422 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BACE2 | CHID1 | 0.82071 | 3 | 0 | 3 |
| BACE2 | ZNF436 | 0.811009 | 3 | 0 | 3 |
| BACE2 | SPATS2L | 0.794732 | 3 | 0 | 3 |
| BACE2 | COX15 | 0.771112 | 3 | 0 | 3 |
| BACE2 | ZNF578 | 0.753469 | 3 | 0 | 3 |
| BACE2 | RRAGB | 0.739793 | 3 | 0 | 3 |
| BACE2 | AP3M1 | 0.738708 | 3 | 0 | 3 |
| BACE2 | UQCRFS1 | 0.73685 | 3 | 0 | 3 |
| BACE2 | CCNB3 | 0.721909 | 3 | 0 | 3 |
| BACE2 | PLAA | 0.709999 | 3 | 0 | 3 |
| BACE2 | KLHDC10 | 0.709881 | 4 | 0 | 3 |
| BACE2 | RWDD2B | 0.704835 | 3 | 0 | 3 |
| BACE2 | ABHD3 | 0.700045 | 3 | 0 | 3 |
| BACE2 | ZNHIT6 | 0.699365 | 3 | 0 | 3 |
| BACE2 | ANKIB1 | 0.698281 | 3 | 0 | 3 |
| BACE2 | TPD52L2 | 0.691085 | 3 | 0 | 3 |
| BACE2 | LDLRAP1 | 0.690324 | 3 | 0 | 3 |
| BACE2 | ACBD5 | 0.686493 | 3 | 0 | 3 |
| BACE2 | TMEM131 | 0.68363 | 3 | 0 | 3 |
| BACE2 | RABEP2 | 0.679411 | 4 | 0 | 3 |
For details and further investigation, click here
