| Full name: low density lipoprotein receptor adaptor protein 1 | Alias Symbol: ARH|ARH2|FHCB1|FHCB2|MGC34705|DKFZp586D0624 | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 26119 | HGNC ID: HGNC:18640 | Ensembl Gene: ENSG00000157978 | OMIM ID: 605747 |
| Drug and gene relationship at DGIdb | |||
Expression of LDLRAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LDLRAP1 | 26119 | 57082_at | 0.7162 | 0.2249 | |
| GSE20347 | LDLRAP1 | 26119 | 57082_at | 0.1409 | 0.3902 | |
| GSE23400 | LDLRAP1 | 26119 | 57082_at | 0.2928 | 0.0000 | |
| GSE26886 | LDLRAP1 | 26119 | 57082_at | -0.2985 | 0.1780 | |
| GSE29001 | LDLRAP1 | 26119 | 57082_at | -0.0345 | 0.8916 | |
| GSE38129 | LDLRAP1 | 26119 | 57082_at | 0.1537 | 0.2378 | |
| GSE45670 | LDLRAP1 | 26119 | 57082_at | 0.3479 | 0.0533 | |
| GSE53622 | LDLRAP1 | 26119 | 67555 | 0.2133 | 0.0085 | |
| GSE53624 | LDLRAP1 | 26119 | 67555 | 0.2555 | 0.0003 | |
| GSE63941 | LDLRAP1 | 26119 | 57082_at | 0.0495 | 0.8977 | |
| GSE77861 | LDLRAP1 | 26119 | 221790_s_at | 0.0729 | 0.7641 | |
| GSE97050 | LDLRAP1 | 26119 | A_32_P216548 | 0.5755 | 0.1058 | |
| SRP007169 | LDLRAP1 | 26119 | RNAseq | 0.4762 | 0.4069 | |
| SRP008496 | LDLRAP1 | 26119 | RNAseq | 0.2143 | 0.5595 | |
| SRP064894 | LDLRAP1 | 26119 | RNAseq | 0.3223 | 0.1641 | |
| SRP133303 | LDLRAP1 | 26119 | RNAseq | 0.1855 | 0.3945 | |
| SRP159526 | LDLRAP1 | 26119 | RNAseq | 0.0867 | 0.7382 | |
| SRP193095 | LDLRAP1 | 26119 | RNAseq | 0.1264 | 0.2227 | |
| SRP219564 | LDLRAP1 | 26119 | RNAseq | 0.1836 | 0.4932 | |
| TCGA | LDLRAP1 | 26119 | RNAseq | 0.0391 | 0.5264 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LDLRAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LDLRAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LDLRAP1 | 26119 | 0 | 5 | 25 | |
| GSE20123 | LDLRAP1 | 26119 | 0 | 4 | 26 | |
| GSE43470 | LDLRAP1 | 26119 | 2 | 6 | 35 | |
| GSE46452 | LDLRAP1 | 26119 | 5 | 1 | 53 | |
| GSE47630 | LDLRAP1 | 26119 | 8 | 3 | 29 | |
| GSE54993 | LDLRAP1 | 26119 | 2 | 1 | 67 | |
| GSE54994 | LDLRAP1 | 26119 | 11 | 4 | 38 | |
| GSE60625 | LDLRAP1 | 26119 | 0 | 0 | 11 | |
| GSE74703 | LDLRAP1 | 26119 | 1 | 4 | 31 | |
| GSE74704 | LDLRAP1 | 26119 | 0 | 0 | 20 | |
| TCGA | LDLRAP1 | 26119 | 9 | 24 | 63 |
Total number of gains: 38; Total number of losses: 52; Total Number of normals: 398.
Somatic mutations of LDLRAP1:
Generating mutation plots.
Highly correlated genes for LDLRAP1:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LDLRAP1 | MAZ | 0.862773 | 3 | 0 | 3 |
| LDLRAP1 | IFT80 | 0.847356 | 3 | 0 | 3 |
| LDLRAP1 | SND1 | 0.8355 | 3 | 0 | 3 |
| LDLRAP1 | FBXW8 | 0.817112 | 3 | 0 | 3 |
| LDLRAP1 | ZBTB39 | 0.795339 | 3 | 0 | 3 |
| LDLRAP1 | PNPLA6 | 0.778233 | 3 | 0 | 3 |
| LDLRAP1 | TTLL4 | 0.774178 | 3 | 0 | 3 |
| LDLRAP1 | AKT1S1 | 0.770664 | 3 | 0 | 3 |
| LDLRAP1 | TAF1C | 0.763678 | 3 | 0 | 3 |
| LDLRAP1 | FLYWCH2 | 0.758449 | 3 | 0 | 3 |
| LDLRAP1 | DOCK1 | 0.755958 | 3 | 0 | 3 |
| LDLRAP1 | ATXN7L3B | 0.75294 | 3 | 0 | 3 |
| LDLRAP1 | ACSS2 | 0.749099 | 3 | 0 | 3 |
| LDLRAP1 | SEPHS1 | 0.748695 | 3 | 0 | 3 |
| LDLRAP1 | ZNF473 | 0.741907 | 3 | 0 | 3 |
| LDLRAP1 | GIT1 | 0.739602 | 4 | 0 | 3 |
| LDLRAP1 | SHISA5 | 0.737478 | 3 | 0 | 3 |
| LDLRAP1 | C10orf88 | 0.729323 | 3 | 0 | 3 |
| LDLRAP1 | CUL7 | 0.728833 | 3 | 0 | 3 |
| LDLRAP1 | TMEM160 | 0.726463 | 3 | 0 | 3 |
For details and further investigation, click here
