| Full name: phospholipase A2 activating protein | Alias Symbol: PLAP|PLA2P|FLJ11281|FLJ12699|DOA1 | ||
| Type: protein-coding gene | Cytoband: 9p21.2 | ||
| Entrez ID: 9373 | HGNC ID: HGNC:9043 | Ensembl Gene: ENSG00000137055 | OMIM ID: 603873 |
| Drug and gene relationship at DGIdb | |||
Expression of PLAA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLAA | 9373 | 209533_s_at | -0.2121 | 0.6398 | |
| GSE20347 | PLAA | 9373 | 209533_s_at | -0.8137 | 0.0025 | |
| GSE23400 | PLAA | 9373 | 209533_s_at | -0.1043 | 0.1878 | |
| GSE26886 | PLAA | 9373 | 209533_s_at | -1.5775 | 0.0000 | |
| GSE29001 | PLAA | 9373 | 209533_s_at | -0.7105 | 0.0106 | |
| GSE38129 | PLAA | 9373 | 209533_s_at | -0.3733 | 0.0607 | |
| GSE45670 | PLAA | 9373 | 209533_s_at | -0.2962 | 0.4495 | |
| GSE53622 | PLAA | 9373 | 19052 | -0.3856 | 0.0000 | |
| GSE53624 | PLAA | 9373 | 19052 | -0.3016 | 0.0001 | |
| GSE63941 | PLAA | 9373 | 209533_s_at | -0.8471 | 0.1192 | |
| GSE77861 | PLAA | 9373 | 209533_s_at | -0.3807 | 0.7192 | |
| GSE97050 | PLAA | 9373 | A_23_P135157 | 0.2546 | 0.3859 | |
| SRP007169 | PLAA | 9373 | RNAseq | -0.1551 | 0.6746 | |
| SRP008496 | PLAA | 9373 | RNAseq | 0.0977 | 0.7036 | |
| SRP064894 | PLAA | 9373 | RNAseq | -0.4730 | 0.0105 | |
| SRP133303 | PLAA | 9373 | RNAseq | -0.1252 | 0.2391 | |
| SRP159526 | PLAA | 9373 | RNAseq | -0.5568 | 0.0299 | |
| SRP193095 | PLAA | 9373 | RNAseq | -0.4019 | 0.0018 | |
| SRP219564 | PLAA | 9373 | RNAseq | -0.8401 | 0.0332 | |
| TCGA | PLAA | 9373 | RNAseq | -0.0312 | 0.6882 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PLAA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLAA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLAA | 9373 | 2 | 14 | 14 | |
| GSE20123 | PLAA | 9373 | 2 | 14 | 14 | |
| GSE43470 | PLAA | 9373 | 2 | 11 | 30 | |
| GSE46452 | PLAA | 9373 | 6 | 18 | 35 | |
| GSE47630 | PLAA | 9373 | 1 | 22 | 17 | |
| GSE54993 | PLAA | 9373 | 7 | 0 | 63 | |
| GSE54994 | PLAA | 9373 | 7 | 15 | 31 | |
| GSE60625 | PLAA | 9373 | 0 | 0 | 11 | |
| GSE74703 | PLAA | 9373 | 2 | 8 | 26 | |
| GSE74704 | PLAA | 9373 | 0 | 11 | 9 | |
| TCGA | PLAA | 9373 | 16 | 46 | 34 |
Total number of gains: 45; Total number of losses: 159; Total Number of normals: 284.
Somatic mutations of PLAA:
Generating mutation plots.
Highly correlated genes for PLAA:
Showing top 20/813 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLAA | HERPUD1 | 0.774429 | 3 | 0 | 3 |
| PLAA | CAAP1 | 0.77353 | 11 | 0 | 11 |
| PLAA | MRPL1 | 0.765111 | 3 | 0 | 3 |
| PLAA | PCGF5 | 0.750785 | 3 | 0 | 3 |
| PLAA | IER3IP1 | 0.748498 | 4 | 0 | 4 |
| PLAA | ANKRD44 | 0.747952 | 3 | 0 | 3 |
| PLAA | SLC12A6 | 0.738254 | 4 | 0 | 4 |
| PLAA | ZNF436 | 0.72731 | 3 | 0 | 3 |
| PLAA | FAM107B | 0.718676 | 3 | 0 | 3 |
| PLAA | SEC11C | 0.71819 | 3 | 0 | 3 |
| PLAA | CDC42EP5 | 0.716962 | 3 | 0 | 3 |
| PLAA | PPP1R8 | 0.716393 | 3 | 0 | 3 |
| PLAA | EIF3I | 0.711602 | 3 | 0 | 3 |
| PLAA | ZNF394 | 0.710895 | 3 | 0 | 3 |
| PLAA | BACE2 | 0.709999 | 3 | 0 | 3 |
| PLAA | AQR | 0.708343 | 4 | 0 | 4 |
| PLAA | ATP6V1C2 | 0.700127 | 3 | 0 | 3 |
| PLAA | RALGPS2 | 0.699348 | 4 | 0 | 3 |
| PLAA | NOA1 | 0.697529 | 3 | 0 | 3 |
| PLAA | GLUD2 | 0.696885 | 4 | 0 | 3 |
For details and further investigation, click here
