| Full name: cytochrome c oxidase assembly homolog COX15 | Alias Symbol: CEMCOX2 | ||
| Type: protein-coding gene | Cytoband: 10q24.2 | ||
| Entrez ID: 1355 | HGNC ID: HGNC:2263 | Ensembl Gene: ENSG00000014919 | OMIM ID: 603646 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COX15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX15 | 1355 | 219547_at | -0.2729 | 0.2389 | |
| GSE20347 | COX15 | 1355 | 219547_at | -0.2280 | 0.0960 | |
| GSE23400 | COX15 | 1355 | 219547_at | 0.0082 | 0.8949 | |
| GSE26886 | COX15 | 1355 | 219547_at | -0.6457 | 0.0149 | |
| GSE29001 | COX15 | 1355 | 219547_at | -0.2283 | 0.2201 | |
| GSE38129 | COX15 | 1355 | 219547_at | -0.2325 | 0.0416 | |
| GSE45670 | COX15 | 1355 | 219547_at | -0.2116 | 0.2167 | |
| GSE53622 | COX15 | 1355 | 32031 | 0.0035 | 0.9725 | |
| GSE53624 | COX15 | 1355 | 32031 | 0.0305 | 0.7925 | |
| GSE63941 | COX15 | 1355 | 223281_s_at | 1.7401 | 0.0000 | |
| GSE77861 | COX15 | 1355 | 219547_at | -0.3840 | 0.0540 | |
| GSE97050 | COX15 | 1355 | A_33_P3409302 | -0.1478 | 0.6309 | |
| SRP007169 | COX15 | 1355 | RNAseq | -0.4575 | 0.2685 | |
| SRP008496 | COX15 | 1355 | RNAseq | -0.3138 | 0.2014 | |
| SRP064894 | COX15 | 1355 | RNAseq | -0.2260 | 0.0625 | |
| SRP133303 | COX15 | 1355 | RNAseq | 0.1259 | 0.5538 | |
| SRP159526 | COX15 | 1355 | RNAseq | -0.1479 | 0.5561 | |
| SRP193095 | COX15 | 1355 | RNAseq | 0.0161 | 0.8394 | |
| SRP219564 | COX15 | 1355 | RNAseq | -0.2724 | 0.3023 | |
| TCGA | COX15 | 1355 | RNAseq | -0.0977 | 0.0364 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by COX15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX15 | 1355 | 1 | 8 | 21 | |
| GSE20123 | COX15 | 1355 | 1 | 7 | 22 | |
| GSE43470 | COX15 | 1355 | 0 | 7 | 36 | |
| GSE46452 | COX15 | 1355 | 0 | 11 | 48 | |
| GSE47630 | COX15 | 1355 | 2 | 14 | 24 | |
| GSE54993 | COX15 | 1355 | 8 | 0 | 62 | |
| GSE54994 | COX15 | 1355 | 1 | 12 | 40 | |
| GSE60625 | COX15 | 1355 | 0 | 0 | 11 | |
| GSE74703 | COX15 | 1355 | 0 | 5 | 31 | |
| GSE74704 | COX15 | 1355 | 0 | 4 | 16 | |
| TCGA | COX15 | 1355 | 5 | 28 | 63 |
Total number of gains: 18; Total number of losses: 96; Total Number of normals: 374.
Somatic mutations of COX15:
Generating mutation plots.
Highly correlated genes for COX15:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX15 | PRPF38A | 0.820782 | 3 | 0 | 3 |
| COX15 | E2F4 | 0.804236 | 3 | 0 | 3 |
| COX15 | COPZ1 | 0.802917 | 3 | 0 | 3 |
| COX15 | FBXO8 | 0.800244 | 3 | 0 | 3 |
| COX15 | SYNE2 | 0.789128 | 3 | 0 | 3 |
| COX15 | RAC1 | 0.778915 | 3 | 0 | 3 |
| COX15 | GLOD4 | 0.777824 | 3 | 0 | 3 |
| COX15 | TPRKB | 0.777743 | 3 | 0 | 3 |
| COX15 | RGS14 | 0.775234 | 3 | 0 | 3 |
| COX15 | BACE2 | 0.771112 | 3 | 0 | 3 |
| COX15 | ARRDC3 | 0.75972 | 3 | 0 | 3 |
| COX15 | MRPL37 | 0.755483 | 3 | 0 | 3 |
| COX15 | SLC35A4 | 0.755339 | 3 | 0 | 3 |
| COX15 | SNAI3 | 0.746145 | 3 | 0 | 3 |
| COX15 | SMURF1 | 0.745079 | 3 | 0 | 3 |
| COX15 | WDR61 | 0.739069 | 3 | 0 | 3 |
| COX15 | AP3M1 | 0.73175 | 4 | 0 | 4 |
| COX15 | FBXW2 | 0.731309 | 4 | 0 | 4 |
| COX15 | SLC18A2 | 0.727523 | 3 | 0 | 3 |
| COX15 | RAB4B | 0.727267 | 3 | 0 | 3 |
For details and further investigation, click here
