| Full name: Bardet-Biedl syndrome 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 585 | HGNC ID: HGNC:969 | Ensembl Gene: ENSG00000140463 | OMIM ID: 600374 |
| Drug and gene relationship at DGIdb | |||
Expression of BBS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BBS4 | 585 | 212744_at | 0.1654 | 0.7944 | |
| GSE20347 | BBS4 | 585 | 212744_at | 0.4134 | 0.0168 | |
| GSE23400 | BBS4 | 585 | 212744_at | 0.0440 | 0.2474 | |
| GSE26886 | BBS4 | 585 | 212745_s_at | -0.0413 | 0.8873 | |
| GSE29001 | BBS4 | 585 | 212745_s_at | 0.7290 | 0.0695 | |
| GSE38129 | BBS4 | 585 | 212744_at | 0.3384 | 0.0583 | |
| GSE45670 | BBS4 | 585 | 212744_at | 0.0110 | 0.9590 | |
| GSE53622 | BBS4 | 585 | 56942 | 0.4303 | 0.0001 | |
| GSE53624 | BBS4 | 585 | 56942 | 0.4357 | 0.0002 | |
| GSE63941 | BBS4 | 585 | 212744_at | -1.5497 | 0.0068 | |
| GSE77861 | BBS4 | 585 | 212744_at | 0.2195 | 0.2413 | |
| GSE97050 | BBS4 | 585 | A_23_P99967 | -0.0892 | 0.7206 | |
| SRP007169 | BBS4 | 585 | RNAseq | 1.1100 | 0.0647 | |
| SRP008496 | BBS4 | 585 | RNAseq | 1.1972 | 0.0125 | |
| SRP064894 | BBS4 | 585 | RNAseq | 0.3621 | 0.0105 | |
| SRP133303 | BBS4 | 585 | RNAseq | 0.2363 | 0.1536 | |
| SRP159526 | BBS4 | 585 | RNAseq | -0.0677 | 0.7293 | |
| SRP193095 | BBS4 | 585 | RNAseq | 0.2965 | 0.0069 | |
| SRP219564 | BBS4 | 585 | RNAseq | 0.1090 | 0.7992 | |
| TCGA | BBS4 | 585 | RNAseq | -0.2051 | 0.0010 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by BBS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BBS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BBS4 | 585 | 8 | 0 | 22 | |
| GSE20123 | BBS4 | 585 | 8 | 0 | 22 | |
| GSE43470 | BBS4 | 585 | 4 | 6 | 33 | |
| GSE46452 | BBS4 | 585 | 3 | 7 | 49 | |
| GSE47630 | BBS4 | 585 | 8 | 10 | 22 | |
| GSE54993 | BBS4 | 585 | 5 | 6 | 59 | |
| GSE54994 | BBS4 | 585 | 5 | 8 | 40 | |
| GSE60625 | BBS4 | 585 | 4 | 4 | 3 | |
| GSE74703 | BBS4 | 585 | 4 | 3 | 29 | |
| GSE74704 | BBS4 | 585 | 4 | 0 | 16 | |
| TCGA | BBS4 | 585 | 12 | 15 | 69 |
Total number of gains: 65; Total number of losses: 59; Total Number of normals: 364.
Somatic mutations of BBS4:
Generating mutation plots.
Highly correlated genes for BBS4:
Showing top 20/855 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BBS4 | EIF4G3 | 0.810135 | 3 | 0 | 3 |
| BBS4 | SLC7A6OS | 0.809247 | 3 | 0 | 3 |
| BBS4 | RRN3 | 0.800306 | 3 | 0 | 3 |
| BBS4 | RNF4 | 0.764162 | 3 | 0 | 3 |
| BBS4 | IL17RD | 0.742773 | 3 | 0 | 3 |
| BBS4 | ELOF1 | 0.733139 | 3 | 0 | 3 |
| BBS4 | TM7SF3 | 0.728153 | 3 | 0 | 3 |
| BBS4 | NEIL2 | 0.72327 | 3 | 0 | 3 |
| BBS4 | CEP192 | 0.720718 | 4 | 0 | 4 |
| BBS4 | YBEY | 0.720655 | 3 | 0 | 3 |
| BBS4 | HEXA | 0.714706 | 7 | 0 | 7 |
| BBS4 | CD63 | 0.710351 | 3 | 0 | 3 |
| BBS4 | SLC39A1 | 0.709099 | 3 | 0 | 3 |
| BBS4 | NDUFAF1 | 0.706722 | 3 | 0 | 3 |
| BBS4 | ZNF225 | 0.705917 | 3 | 0 | 3 |
| BBS4 | PTPRD | 0.704944 | 3 | 0 | 3 |
| BBS4 | LSM10 | 0.70423 | 4 | 0 | 4 |
| BBS4 | TRIM35 | 0.704222 | 3 | 0 | 3 |
| BBS4 | ZFAND3 | 0.700187 | 3 | 0 | 3 |
| BBS4 | SLC38A10 | 0.699467 | 4 | 0 | 3 |
For details and further investigation, click here
