PTPRD

 

Full name: protein tyrosine phosphatase receptor type D Alias Symbol: PTPD|HPTP
Type: protein-coding gene Cytoband: 9p24.1-p23
Entrez ID: 5789 HGNC ID: HGNC:9668 Ensembl Gene: ENSG00000153707 OMIM ID: 601598
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PTPRD:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTPRD 5789 214043_at -0.4342 0.7856
GSE20347 PTPRD 5789 214043_at -0.1484 0.6834
GSE23400 PTPRD 5789 205712_at -0.0729 0.1535
GSE26886 PTPRD 5789 214043_at 1.8996 0.0098
GSE29001 PTPRD 5789 214043_at -0.6142 0.1285
GSE38129 PTPRD 5789 214043_at -0.0930 0.8337
GSE45670 PTPRD 5789 214043_at -0.9164 0.0670
GSE53622 PTPRD 5789 41703 -0.0404 0.8784
GSE53624 PTPRD 5789 41703 0.2439 0.2306
GSE63941 PTPRD 5789 214043_at -2.9526 0.0043
GSE77861 PTPRD 5789 205712_at 0.0174 0.9366
GSE97050 PTPRD 5789 A_33_P3309551 -0.2543 0.4930
SRP007169 PTPRD 5789 RNAseq 3.3180 0.0001
SRP008496 PTPRD 5789 RNAseq 3.6759 0.0000
SRP064894 PTPRD 5789 RNAseq 0.6617 0.1409
SRP133303 PTPRD 5789 RNAseq 0.0837 0.8563
SRP159526 PTPRD 5789 RNAseq 1.1038 0.2174
SRP193095 PTPRD 5789 RNAseq 0.5618 0.1226
SRP219564 PTPRD 5789 RNAseq 1.1407 0.1687
TCGA PTPRD 5789 RNAseq -0.0598 0.8507

Upregulated datasets: 3; Downregulated datasets: 1.  

 

Survival by PTPRD expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTPRD:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTPRD 5789 2 16 12
GSE20123 PTPRD 5789 2 16 12
GSE43470 PTPRD 5789 4 14 25
GSE46452 PTPRD 5789 2 23 34
GSE47630 PTPRD 5789 4 27 9
GSE54993 PTPRD 5789 6 3 61
GSE54994 PTPRD 5789 10 16 27
GSE60625 PTPRD 5789 0 2 9
GSE74703 PTPRD 5789 4 11 21
GSE74704 PTPRD 5789 0 13 7
TCGA PTPRD 5789 14 52 30

Total number of gains: 48; Total number of losses: 193; Total Number of normals: 247.  

 

Somatic mutations of PTPRD:

 

Generating mutation plots.

 

Highly correlated genes for PTPRD:

 

Showing top 20/250 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTPRDGLI30.729422303
PTPRDRAB8B0.726773303
PTPRDRNF2140.722646303
PTPRDFNIP10.716469303
PTPRDFGFR10.708712303
PTPRDBBS40.704944303
PTPRDKIAA0895L0.70312303
PTPRDPCDH180.698459403
PTPRDIL13RA20.695406303
PTPRDPRRX10.69098403
PTPRDMSI20.67371303
PTPRDTGFB30.670604403
PTPRDSH2B30.67058303
PTPRDELFN10.66902303
PTPRDRAPGEF20.668401303
PTPRDPOLK0.667735303
PTPRDTRIB20.660906303
PTPRDIGFBP50.660295403
PTPRDMPP10.658601403
PTPRDKCNJ20.657263403

For details and further investigation, click here