| Full name: hexosaminidase subunit alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q23 | ||
| Entrez ID: 3073 | HGNC ID: HGNC:4878 | Ensembl Gene: ENSG00000213614 | OMIM ID: 606869 |
| Drug and gene relationship at DGIdb | |||
Expression of HEXA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HEXA | 3073 | 201765_s_at | 0.4062 | 0.3539 | |
| GSE20347 | HEXA | 3073 | 201765_s_at | 1.0095 | 0.0002 | |
| GSE23400 | HEXA | 3073 | 201765_s_at | 0.4921 | 0.0000 | |
| GSE26886 | HEXA | 3073 | 201765_s_at | 0.8610 | 0.0101 | |
| GSE29001 | HEXA | 3073 | 201765_s_at | 0.8532 | 0.0024 | |
| GSE38129 | HEXA | 3073 | 201765_s_at | 0.8021 | 0.0001 | |
| GSE45670 | HEXA | 3073 | 201765_s_at | 0.2228 | 0.2077 | |
| GSE63941 | HEXA | 3073 | 201765_s_at | -0.9556 | 0.3173 | |
| GSE77861 | HEXA | 3073 | 201765_s_at | 0.3972 | 0.1555 | |
| GSE97050 | HEXA | 3073 | A_23_P129101 | 0.4549 | 0.2110 | |
| SRP007169 | HEXA | 3073 | RNAseq | 2.2748 | 0.0000 | |
| SRP008496 | HEXA | 3073 | RNAseq | 2.0896 | 0.0000 | |
| SRP064894 | HEXA | 3073 | RNAseq | 0.8905 | 0.0000 | |
| SRP133303 | HEXA | 3073 | RNAseq | 0.5625 | 0.0000 | |
| SRP159526 | HEXA | 3073 | RNAseq | 0.7255 | 0.0674 | |
| SRP193095 | HEXA | 3073 | RNAseq | 0.6429 | 0.0000 | |
| SRP219564 | HEXA | 3073 | RNAseq | 0.6577 | 0.0183 | |
| TCGA | HEXA | 3073 | RNAseq | -0.0113 | 0.8183 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by HEXA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HEXA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HEXA | 3073 | 8 | 0 | 22 | |
| GSE20123 | HEXA | 3073 | 8 | 0 | 22 | |
| GSE43470 | HEXA | 3073 | 4 | 6 | 33 | |
| GSE46452 | HEXA | 3073 | 3 | 7 | 49 | |
| GSE47630 | HEXA | 3073 | 8 | 10 | 22 | |
| GSE54993 | HEXA | 3073 | 5 | 6 | 59 | |
| GSE54994 | HEXA | 3073 | 5 | 8 | 40 | |
| GSE60625 | HEXA | 3073 | 4 | 4 | 3 | |
| GSE74703 | HEXA | 3073 | 4 | 3 | 29 | |
| GSE74704 | HEXA | 3073 | 4 | 0 | 16 | |
| TCGA | HEXA | 3073 | 12 | 15 | 69 |
Total number of gains: 65; Total number of losses: 59; Total Number of normals: 364.
Somatic mutations of HEXA:
Generating mutation plots.
Highly correlated genes for HEXA:
Showing top 20/1298 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HEXA | POLR2J | 0.843516 | 3 | 0 | 3 |
| HEXA | C1orf43 | 0.79477 | 3 | 0 | 3 |
| HEXA | GCLC | 0.794442 | 3 | 0 | 3 |
| HEXA | CCDC127 | 0.793233 | 3 | 0 | 3 |
| HEXA | ZNF518B | 0.787424 | 3 | 0 | 3 |
| HEXA | C7orf50 | 0.786237 | 3 | 0 | 3 |
| HEXA | BUD31 | 0.763979 | 3 | 0 | 3 |
| HEXA | XPO7 | 0.755191 | 4 | 0 | 4 |
| HEXA | TMED8 | 0.746016 | 5 | 0 | 5 |
| HEXA | NEK6 | 0.742507 | 4 | 0 | 4 |
| HEXA | KIAA0895 | 0.7384 | 3 | 0 | 3 |
| HEXA | CNPY2 | 0.733107 | 5 | 0 | 5 |
| HEXA | MED10 | 0.731146 | 4 | 0 | 3 |
| HEXA | EGFLAM | 0.725902 | 3 | 0 | 3 |
| HEXA | HAX1 | 0.725472 | 3 | 0 | 3 |
| HEXA | ZFYVE27 | 0.723271 | 4 | 0 | 4 |
| HEXA | TIMP1 | 0.723144 | 9 | 0 | 9 |
| HEXA | POC5 | 0.72142 | 4 | 0 | 4 |
| HEXA | XXYLT1 | 0.719825 | 3 | 0 | 3 |
| HEXA | NEDD1 | 0.715105 | 4 | 0 | 4 |
For details and further investigation, click here
