TRIM35

 

Full name: tripartite motif containing 35 Alias Symbol: KIAA1098|MAIR|HLS5
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 23087 HGNC ID: HGNC:16285 Ensembl Gene: ENSG00000104228 OMIM ID: 617007
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TRIM35:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TRIM35 23087 227102_at 0.3632 0.4277
GSE26886 TRIM35 23087 227102_at 0.5243 0.0143
GSE45670 TRIM35 23087 227102_at 0.1335 0.4073
GSE53622 TRIM35 23087 49972 -0.0905 0.3327
GSE53624 TRIM35 23087 49972 0.1266 0.1035
GSE63941 TRIM35 23087 227102_at -1.3702 0.0036
GSE77861 TRIM35 23087 227102_at 0.0964 0.3599
GSE97050 TRIM35 23087 A_23_P502553 0.0426 0.8728
SRP007169 TRIM35 23087 RNAseq -0.4742 0.2545
SRP008496 TRIM35 23087 RNAseq -0.2677 0.3011
SRP064894 TRIM35 23087 RNAseq -0.1073 0.4847
SRP133303 TRIM35 23087 RNAseq -0.3061 0.1243
SRP159526 TRIM35 23087 RNAseq -0.2235 0.4059
SRP193095 TRIM35 23087 RNAseq -0.0189 0.8759
SRP219564 TRIM35 23087 RNAseq 0.2225 0.5664
TCGA TRIM35 23087 RNAseq 0.1244 0.0933

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by TRIM35 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TRIM35:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TRIM35 23087 4 11 15
GSE20123 TRIM35 23087 4 11 15
GSE43470 TRIM35 23087 4 7 32
GSE46452 TRIM35 23087 13 13 33
GSE47630 TRIM35 23087 10 8 22
GSE54993 TRIM35 23087 2 15 53
GSE54994 TRIM35 23087 10 15 28
GSE60625 TRIM35 23087 3 0 8
GSE74703 TRIM35 23087 4 6 26
GSE74704 TRIM35 23087 3 8 9
TCGA TRIM35 23087 16 43 37

Total number of gains: 73; Total number of losses: 137; Total Number of normals: 278.  

 

Somatic mutations of TRIM35:

 

Generating mutation plots.

 

Highly correlated genes for TRIM35:

 

Showing top 20/261 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TRIM35CEP970.831292303
TRIM35ABHD20.805152303
TRIM35RRM2B0.805081303
TRIM35RRAS20.796517303
TRIM35TNPO10.790932303
TRIM35PAK20.782156303
TRIM35PUM10.776877303
TRIM35FIBP0.774433303
TRIM35DHX150.763942303
TRIM35USF10.760011303
TRIM35GDAP10.758718303
TRIM35OAF0.752599303
TRIM35SCRN10.748524303
TRIM35FAM13A0.74799303
TRIM35LSM100.747819303
TRIM35GAA0.742771303
TRIM35ACVR10.739569404
TRIM35MNAT10.731183303
TRIM35VASP0.728777303
TRIM35ILKAP0.728392404

For details and further investigation, click here