BCL2

 

Full name: BCL2 apoptosis regulator Alias Symbol: Bcl-2|PPP1R50
Type: protein-coding gene Cytoband: 18q21.33
Entrez ID: 596 HGNC ID: HGNC:990 Ensembl Gene: ENSG00000171791 OMIM ID: 151430
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 13/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

BCL2 involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04066HIF-1 signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04340Hedgehog signaling pathway
hsa04510Focal adhesion
hsa04630Jak-STAT signaling pathway
hsa04725Cholinergic synapse
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05215Prostate cancer

 

Expression of BCL2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BCL2 596 203685_at -0.7412 0.5623
GSE20347 BCL2 596 203685_at 0.3057 0.4137
GSE23400 BCL2 596 203685_at -0.0037 0.9738
GSE26886 BCL2 596 203685_at 0.5364 0.4283
GSE29001 BCL2 596 203685_at -0.1271 0.8525
GSE38129 BCL2 596 203685_at -0.2325 0.5808
GSE45670 BCL2 596 207004_at -0.0830 0.4136
GSE53622 BCL2 596 16891 -0.3421 0.0058
GSE53624 BCL2 596 16891 -0.2145 0.0082
GSE63941 BCL2 596 207004_at -0.2584 0.1748
GSE77861 BCL2 596 207004_at -0.0811 0.6727
GSE97050 BCL2 596 A_33_P3355185 -0.3000 0.2502
SRP007169 BCL2 596 RNAseq -0.0636 0.9271
SRP008496 BCL2 596 RNAseq -0.4413 0.2663
SRP064894 BCL2 596 RNAseq -0.9160 0.0016
SRP133303 BCL2 596 RNAseq -0.5014 0.0443
SRP159526 BCL2 596 RNAseq 0.1598 0.6747
SRP193095 BCL2 596 RNAseq -0.3518 0.1253
SRP219564 BCL2 596 RNAseq -0.1613 0.7826
TCGA BCL2 596 RNAseq -0.3309 0.0214

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by BCL2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BCL2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BCL2 596 1 9 20
GSE20123 BCL2 596 1 9 20
GSE43470 BCL2 596 0 7 36
GSE46452 BCL2 596 1 26 32
GSE47630 BCL2 596 5 21 14
GSE54993 BCL2 596 9 0 61
GSE54994 BCL2 596 1 18 34
GSE60625 BCL2 596 0 4 7
GSE74703 BCL2 596 0 7 29
GSE74704 BCL2 596 1 6 13
TCGA BCL2 596 10 45 41

Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.  

 

Somatic mutations of BCL2:

 

Generating mutation plots.

 

Highly correlated genes for BCL2:

 

Showing top 20/329 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BCL2NUDT160.763166303
BCL2BCAT20.709991303
BCL2DISP10.709424303
BCL2GPR260.701532303
BCL2CDO10.701341403
BCL2PIP5K1B0.697245505
BCL2TMEM8B0.69561606
BCL2FGF130.692404404
BCL2ZNF3580.688295404
BCL2BEND50.679418706
BCL2STXBP60.674289606
BCL2PTGIS0.673141605
BCL2ADCY50.671641504
BCL2FAM117A0.669408808
BCL2KANK20.665853403
BCL2LRRC4B0.663355303
BCL2MYEF20.662959303
BCL2BEX10.659409504
BCL2PROM10.655379504
BCL2TSPYL50.654015503

For details and further investigation, click here