| Full name: leucine rich repeat containing 4B | Alias Symbol: DKFZp761A179|HSM | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 94030 | HGNC ID: HGNC:25042 | Ensembl Gene: ENSG00000131409 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LRRC4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC4B | 94030 | 239320_at | -0.0396 | 0.9088 | |
| GSE26886 | LRRC4B | 94030 | 239320_at | 0.2651 | 0.0308 | |
| GSE45670 | LRRC4B | 94030 | 239320_at | -0.0342 | 0.6492 | |
| GSE53622 | LRRC4B | 94030 | 18735 | -1.0894 | 0.0000 | |
| GSE53624 | LRRC4B | 94030 | 18735 | -0.7049 | 0.0000 | |
| GSE63941 | LRRC4B | 94030 | 239320_at | 0.3981 | 0.0733 | |
| GSE77861 | LRRC4B | 94030 | 239320_at | -0.1658 | 0.1761 | |
| GSE97050 | LRRC4B | 94030 | A_23_P419503 | -0.5205 | 0.3408 | |
| SRP133303 | LRRC4B | 94030 | RNAseq | -1.7406 | 0.0000 | |
| SRP159526 | LRRC4B | 94030 | RNAseq | -0.1363 | 0.8035 | |
| SRP219564 | LRRC4B | 94030 | RNAseq | -0.8701 | 0.2575 | |
| TCGA | LRRC4B | 94030 | RNAseq | -0.6730 | 0.0015 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LRRC4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC4B | 94030 | 3 | 4 | 23 | |
| GSE20123 | LRRC4B | 94030 | 3 | 3 | 24 | |
| GSE43470 | LRRC4B | 94030 | 4 | 11 | 28 | |
| GSE46452 | LRRC4B | 94030 | 45 | 1 | 13 | |
| GSE47630 | LRRC4B | 94030 | 10 | 6 | 24 | |
| GSE54993 | LRRC4B | 94030 | 17 | 4 | 49 | |
| GSE54994 | LRRC4B | 94030 | 4 | 14 | 35 | |
| GSE60625 | LRRC4B | 94030 | 9 | 0 | 2 | |
| GSE74703 | LRRC4B | 94030 | 4 | 7 | 25 | |
| GSE74704 | LRRC4B | 94030 | 3 | 1 | 16 | |
| TCGA | LRRC4B | 94030 | 14 | 19 | 63 |
Total number of gains: 116; Total number of losses: 70; Total Number of normals: 302.
Somatic mutations of LRRC4B:
Generating mutation plots.
Highly correlated genes for LRRC4B:
Showing top 20/87 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC4B | MAP2K7 | 0.70915 | 3 | 0 | 3 |
| LRRC4B | ACTR1B | 0.700197 | 3 | 0 | 3 |
| LRRC4B | DHDH | 0.669728 | 3 | 0 | 3 |
| LRRC4B | ZNF835 | 0.664301 | 3 | 0 | 3 |
| LRRC4B | HCN2 | 0.664111 | 3 | 0 | 3 |
| LRRC4B | BCL2 | 0.663355 | 3 | 0 | 3 |
| LRRC4B | SLC9A3R2 | 0.660617 | 3 | 0 | 3 |
| LRRC4B | CACNA1H | 0.654275 | 4 | 0 | 4 |
| LRRC4B | HOXD12 | 0.649693 | 3 | 0 | 3 |
| LRRC4B | MAG | 0.644292 | 4 | 0 | 3 |
| LRRC4B | FAIM2 | 0.643151 | 5 | 0 | 4 |
| LRRC4B | NTRK1 | 0.639411 | 3 | 0 | 3 |
| LRRC4B | MIIP | 0.631506 | 3 | 0 | 3 |
| LRRC4B | IL17B | 0.628407 | 5 | 0 | 4 |
| LRRC4B | SSTR3 | 0.625476 | 4 | 0 | 3 |
| LRRC4B | CLEC14A | 0.622245 | 4 | 0 | 3 |
| LRRC4B | MMD2 | 0.622221 | 3 | 0 | 3 |
| LRRC4B | TNRC6C | 0.611511 | 4 | 0 | 3 |
| LRRC4B | MS4A3 | 0.611232 | 3 | 0 | 3 |
| LRRC4B | UPK3A | 0.604702 | 3 | 0 | 3 |
For details and further investigation, click here
