| Full name: phosphatidylinositol-4-phosphate 5-kinase type 1 beta | Alias Symbol: STM7|MSS4 | ||
| Type: protein-coding gene | Cytoband: 9q21.11 | ||
| Entrez ID: 8395 | HGNC ID: HGNC:8995 | Ensembl Gene: ENSG00000107242 | OMIM ID: 602745 |
| Drug and gene relationship at DGIdb | |||
PIP5K1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04666 | Fc gamma R-mediated phagocytosis | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05231 | Choline metabolism in cancer |
Expression of PIP5K1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PIP5K1B | 8395 | 205632_s_at | -0.3264 | 0.7883 | |
| GSE20347 | PIP5K1B | 8395 | 205632_s_at | 0.1011 | 0.3322 | |
| GSE23400 | PIP5K1B | 8395 | 217477_at | -0.0783 | 0.0069 | |
| GSE26886 | PIP5K1B | 8395 | 205632_s_at | 0.4076 | 0.2968 | |
| GSE29001 | PIP5K1B | 8395 | 205632_s_at | 0.2348 | 0.3904 | |
| GSE38129 | PIP5K1B | 8395 | 205632_s_at | -0.1077 | 0.7325 | |
| GSE45670 | PIP5K1B | 8395 | 205632_s_at | -0.2845 | 0.4775 | |
| GSE53622 | PIP5K1B | 8395 | 13629 | -0.1663 | 0.3906 | |
| GSE53624 | PIP5K1B | 8395 | 23921 | -0.8281 | 0.0019 | |
| GSE63941 | PIP5K1B | 8395 | 205632_s_at | 0.5807 | 0.4790 | |
| GSE77861 | PIP5K1B | 8395 | 217477_at | -0.0357 | 0.6964 | |
| GSE97050 | PIP5K1B | 8395 | A_33_P3256725 | 0.1643 | 0.5767 | |
| SRP133303 | PIP5K1B | 8395 | RNAseq | 0.5036 | 0.3310 | |
| SRP159526 | PIP5K1B | 8395 | RNAseq | 0.8839 | 0.1789 | |
| SRP219564 | PIP5K1B | 8395 | RNAseq | -0.5845 | 0.2521 | |
| TCGA | PIP5K1B | 8395 | RNAseq | -1.8302 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PIP5K1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PIP5K1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PIP5K1B | 8395 | 6 | 10 | 14 | |
| GSE20123 | PIP5K1B | 8395 | 6 | 10 | 14 | |
| GSE43470 | PIP5K1B | 8395 | 6 | 5 | 32 | |
| GSE46452 | PIP5K1B | 8395 | 7 | 14 | 38 | |
| GSE47630 | PIP5K1B | 8395 | 1 | 19 | 20 | |
| GSE54993 | PIP5K1B | 8395 | 5 | 1 | 64 | |
| GSE54994 | PIP5K1B | 8395 | 4 | 13 | 36 | |
| GSE60625 | PIP5K1B | 8395 | 0 | 0 | 11 | |
| GSE74703 | PIP5K1B | 8395 | 5 | 4 | 27 | |
| GSE74704 | PIP5K1B | 8395 | 3 | 7 | 10 | |
| TCGA | PIP5K1B | 8395 | 18 | 28 | 50 |
Total number of gains: 61; Total number of losses: 111; Total Number of normals: 316.
Somatic mutations of PIP5K1B:
Generating mutation plots.
Highly correlated genes for PIP5K1B:
Showing top 20/335 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PIP5K1B | WDR19 | 0.739484 | 3 | 0 | 3 |
| PIP5K1B | AGBL5 | 0.702414 | 4 | 0 | 4 |
| PIP5K1B | ELAC1 | 0.69959 | 4 | 0 | 3 |
| PIP5K1B | BCL2 | 0.697245 | 5 | 0 | 5 |
| PIP5K1B | POU2AF1 | 0.69688 | 3 | 0 | 3 |
| PIP5K1B | TCTN2 | 0.695692 | 3 | 0 | 3 |
| PIP5K1B | SLC1A1 | 0.692847 | 3 | 0 | 3 |
| PIP5K1B | MAT2B | 0.691708 | 3 | 0 | 3 |
| PIP5K1B | ZNF664 | 0.685212 | 3 | 0 | 3 |
| PIP5K1B | ING4 | 0.683318 | 4 | 0 | 3 |
| PIP5K1B | ZIK1 | 0.674197 | 3 | 0 | 3 |
| PIP5K1B | LIFR | 0.674176 | 7 | 0 | 7 |
| PIP5K1B | RRAGB | 0.673898 | 4 | 0 | 3 |
| PIP5K1B | NUDT16 | 0.671893 | 5 | 0 | 4 |
| PIP5K1B | MRI1 | 0.669371 | 3 | 0 | 3 |
| PIP5K1B | ZNF616 | 0.66807 | 3 | 0 | 3 |
| PIP5K1B | CCND1 | 0.666865 | 3 | 0 | 3 |
| PIP5K1B | TSHZ1 | 0.662252 | 3 | 0 | 3 |
| PIP5K1B | USP13 | 0.659875 | 5 | 0 | 5 |
| PIP5K1B | CD200 | 0.658932 | 5 | 0 | 5 |
For details and further investigation, click here
