BCL2L11

 

Full name: BCL2 like 11 Alias Symbol: BOD|BimL|BimEL|BimS|BIM
Type: protein-coding gene Cytoband: 2q13
Entrez ID: 10018 HGNC ID: HGNC:994 Ensembl Gene: ENSG00000153094 OMIM ID: 603827
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

BCL2L11 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04932Non-alcoholic fatty liver disease (NAFLD)

 

Expression of BCL2L11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BCL2L11 10018 225606_at 0.4849 0.3667
GSE20347 BCL2L11 10018 222343_at 0.3478 0.0100
GSE23400 BCL2L11 10018 222343_at 0.0949 0.0117
GSE26886 BCL2L11 10018 225606_at 0.7118 0.0077
GSE29001 BCL2L11 10018 222343_at 0.6011 0.0369
GSE38129 BCL2L11 10018 222343_at 0.5187 0.0000
GSE45670 BCL2L11 10018 225606_at 0.3301 0.0353
GSE53622 BCL2L11 10018 27651 0.6894 0.0000
GSE53624 BCL2L11 10018 27651 0.6782 0.0000
GSE63941 BCL2L11 10018 225606_at 1.5514 0.0940
GSE77861 BCL2L11 10018 1553096_s_at -0.1401 0.3292
GSE97050 BCL2L11 10018 A_33_P3398526 0.9552 0.1496
SRP007169 BCL2L11 10018 RNAseq 0.2005 0.6684
SRP008496 BCL2L11 10018 RNAseq -1.2864 0.1254
SRP064894 BCL2L11 10018 RNAseq 0.3308 0.1474
SRP133303 BCL2L11 10018 RNAseq 0.6135 0.0032
SRP159526 BCL2L11 10018 RNAseq 0.6389 0.0308
SRP193095 BCL2L11 10018 RNAseq 0.2944 0.0382
SRP219564 BCL2L11 10018 RNAseq -0.0289 0.9328
TCGA BCL2L11 10018 RNAseq 0.2325 0.0001

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by BCL2L11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BCL2L11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BCL2L11 10018 4 2 24
GSE20123 BCL2L11 10018 4 2 24
GSE43470 BCL2L11 10018 3 1 39
GSE46452 BCL2L11 10018 1 4 54
GSE47630 BCL2L11 10018 7 0 33
GSE54993 BCL2L11 10018 0 6 64
GSE54994 BCL2L11 10018 10 0 43
GSE60625 BCL2L11 10018 0 3 8
GSE74703 BCL2L11 10018 3 1 32
GSE74704 BCL2L11 10018 2 2 16
TCGA BCL2L11 10018 31 5 60

Total number of gains: 65; Total number of losses: 26; Total Number of normals: 397.  

 

Somatic mutations of BCL2L11:

 

Generating mutation plots.

 

Highly correlated genes for BCL2L11:

 

Showing top 20/374 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BCL2L11GZMA0.854195303
BCL2L11SPOCK20.826525303
BCL2L11VASH10.80235303
BCL2L11SUSD30.776741403
BCL2L11KLRC30.745368303
BCL2L11ACAP10.736724403
BCL2L11ENPP50.728664303
BCL2L11SSBP40.719337303
BCL2L11XXYLT10.71782303
BCL2L11FAM78A0.715198303
BCL2L11DERL30.710592303
BCL2L11CDCA70.706039404
BCL2L11SGPL10.704932303
BCL2L11HAVCR20.697338303
BCL2L11LAPTM50.696507403
BCL2L11CCDC970.694023404
BCL2L11LPXN0.687762303
BCL2L11FUT80.684041403
BCL2L11RFXAP0.682878404
BCL2L11DHRSX0.682592303

For details and further investigation, click here