| Full name: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 | Alias Symbol: KIAA0275|testican-2 | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 9806 | HGNC ID: HGNC:13564 | Ensembl Gene: ENSG00000107742 | OMIM ID: 607988 |
| Drug and gene relationship at DGIdb | |||
Expression of SPOCK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPOCK2 | 9806 | 202524_s_at | 0.0512 | 0.9676 | |
| GSE20347 | SPOCK2 | 9806 | 202523_s_at | 0.0846 | 0.3526 | |
| GSE23400 | SPOCK2 | 9806 | 202523_s_at | 0.0040 | 0.9503 | |
| GSE26886 | SPOCK2 | 9806 | 202524_s_at | -0.3277 | 0.2823 | |
| GSE29001 | SPOCK2 | 9806 | 202523_s_at | 0.0598 | 0.7599 | |
| GSE38129 | SPOCK2 | 9806 | 202523_s_at | 0.0044 | 0.9638 | |
| GSE45670 | SPOCK2 | 9806 | 202524_s_at | -0.1698 | 0.2268 | |
| GSE53622 | SPOCK2 | 9806 | 33109 | -0.3675 | 0.0211 | |
| GSE53624 | SPOCK2 | 9806 | 33109 | -0.4326 | 0.0011 | |
| GSE63941 | SPOCK2 | 9806 | 202523_s_at | 0.0049 | 0.9790 | |
| GSE77861 | SPOCK2 | 9806 | 202523_s_at | -0.0798 | 0.5383 | |
| GSE97050 | SPOCK2 | 9806 | A_33_P3214948 | 0.7265 | 0.1555 | |
| SRP007169 | SPOCK2 | 9806 | RNAseq | -0.0748 | 0.9121 | |
| SRP064894 | SPOCK2 | 9806 | RNAseq | 0.0278 | 0.9306 | |
| SRP133303 | SPOCK2 | 9806 | RNAseq | -0.5491 | 0.0632 | |
| SRP159526 | SPOCK2 | 9806 | RNAseq | -0.7345 | 0.2939 | |
| SRP193095 | SPOCK2 | 9806 | RNAseq | 0.2349 | 0.4242 | |
| SRP219564 | SPOCK2 | 9806 | RNAseq | 0.2631 | 0.5591 | |
| TCGA | SPOCK2 | 9806 | RNAseq | -0.3010 | 0.0383 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPOCK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPOCK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPOCK2 | 9806 | 3 | 4 | 23 | |
| GSE20123 | SPOCK2 | 9806 | 3 | 3 | 24 | |
| GSE43470 | SPOCK2 | 9806 | 1 | 8 | 34 | |
| GSE46452 | SPOCK2 | 9806 | 0 | 11 | 48 | |
| GSE47630 | SPOCK2 | 9806 | 2 | 14 | 24 | |
| GSE54993 | SPOCK2 | 9806 | 7 | 0 | 63 | |
| GSE54994 | SPOCK2 | 9806 | 2 | 11 | 40 | |
| GSE60625 | SPOCK2 | 9806 | 0 | 0 | 11 | |
| GSE74703 | SPOCK2 | 9806 | 1 | 5 | 30 | |
| GSE74704 | SPOCK2 | 9806 | 2 | 1 | 17 | |
| TCGA | SPOCK2 | 9806 | 11 | 23 | 62 |
Total number of gains: 32; Total number of losses: 80; Total Number of normals: 376.
Somatic mutations of SPOCK2:
Generating mutation plots.
Highly correlated genes for SPOCK2:
Showing top 20/607 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPOCK2 | BCL2L11 | 0.826525 | 3 | 0 | 3 |
| SPOCK2 | ZBTB33 | 0.777706 | 3 | 0 | 3 |
| SPOCK2 | CORO1A | 0.767416 | 7 | 0 | 7 |
| SPOCK2 | CD48 | 0.755267 | 6 | 0 | 6 |
| SPOCK2 | GPR174 | 0.753921 | 3 | 0 | 3 |
| SPOCK2 | PPP1R16B | 0.749443 | 5 | 0 | 5 |
| SPOCK2 | FAM78A | 0.746802 | 4 | 0 | 4 |
| SPOCK2 | EVI2B | 0.742776 | 7 | 0 | 7 |
| SPOCK2 | CD52 | 0.733615 | 6 | 0 | 6 |
| SPOCK2 | SIT1 | 0.727845 | 6 | 0 | 5 |
| SPOCK2 | FHL3 | 0.71729 | 3 | 0 | 3 |
| SPOCK2 | RAB39B | 0.714333 | 4 | 0 | 4 |
| SPOCK2 | KLRB1 | 0.711261 | 7 | 0 | 6 |
| SPOCK2 | HMHB1 | 0.710185 | 3 | 0 | 3 |
| SPOCK2 | SNX20 | 0.708445 | 7 | 0 | 7 |
| SPOCK2 | LGALS2 | 0.707722 | 7 | 0 | 7 |
| SPOCK2 | PARVG | 0.70721 | 7 | 0 | 7 |
| SPOCK2 | C16orf54 | 0.706265 | 6 | 0 | 5 |
| SPOCK2 | HLA-DMB | 0.705568 | 7 | 0 | 7 |
| SPOCK2 | MIR142 | 0.70188 | 3 | 0 | 3 |
For details and further investigation, click here
