| Full name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | Alias Symbol: KIAA0050 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 9744 | HGNC ID: HGNC:16467 | Ensembl Gene: ENSG00000072818 | OMIM ID: 607763 |
| Drug and gene relationship at DGIdb | |||
Expression of ACAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACAP1 | 9744 | 205213_at | 0.6112 | 0.5271 | |
| GSE20347 | ACAP1 | 9744 | 205212_s_at | -0.1556 | 0.1146 | |
| GSE23400 | ACAP1 | 9744 | 205213_at | -0.1677 | 0.0027 | |
| GSE26886 | ACAP1 | 9744 | 205212_s_at | 0.4370 | 0.0169 | |
| GSE29001 | ACAP1 | 9744 | 205213_at | -0.2421 | 0.2289 | |
| GSE38129 | ACAP1 | 9744 | 205213_at | -0.2699 | 0.1693 | |
| GSE45670 | ACAP1 | 9744 | 242081_at | -0.0753 | 0.5193 | |
| GSE53622 | ACAP1 | 9744 | 64803 | -0.3499 | 0.0673 | |
| GSE53624 | ACAP1 | 9744 | 64803 | -0.5547 | 0.0000 | |
| GSE63941 | ACAP1 | 9744 | 242081_at | -0.0260 | 0.9378 | |
| GSE77861 | ACAP1 | 9744 | 242081_at | 0.0321 | 0.8771 | |
| GSE97050 | ACAP1 | 9744 | A_23_P107336 | 0.7142 | 0.2467 | |
| SRP007169 | ACAP1 | 9744 | RNAseq | 0.4040 | 0.5946 | |
| SRP064894 | ACAP1 | 9744 | RNAseq | 0.1698 | 0.5598 | |
| SRP133303 | ACAP1 | 9744 | RNAseq | -0.5510 | 0.0102 | |
| SRP159526 | ACAP1 | 9744 | RNAseq | -1.0900 | 0.0776 | |
| SRP193095 | ACAP1 | 9744 | RNAseq | -0.1950 | 0.2136 | |
| SRP219564 | ACAP1 | 9744 | RNAseq | 0.2755 | 0.4926 | |
| TCGA | ACAP1 | 9744 | RNAseq | 0.0975 | 0.5806 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACAP1 | 9744 | 4 | 2 | 24 | |
| GSE20123 | ACAP1 | 9744 | 4 | 3 | 23 | |
| GSE43470 | ACAP1 | 9744 | 1 | 4 | 38 | |
| GSE46452 | ACAP1 | 9744 | 34 | 1 | 24 | |
| GSE47630 | ACAP1 | 9744 | 7 | 1 | 32 | |
| GSE54993 | ACAP1 | 9744 | 4 | 3 | 63 | |
| GSE54994 | ACAP1 | 9744 | 5 | 8 | 40 | |
| GSE60625 | ACAP1 | 9744 | 4 | 0 | 7 | |
| GSE74703 | ACAP1 | 9744 | 1 | 2 | 33 | |
| GSE74704 | ACAP1 | 9744 | 2 | 1 | 17 | |
| TCGA | ACAP1 | 9744 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of ACAP1:
Generating mutation plots.
Highly correlated genes for ACAP1:
Showing top 20/343 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACAP1 | SNX20 | 0.851966 | 4 | 0 | 4 |
| ACAP1 | IL18BP | 0.776559 | 3 | 0 | 3 |
| ACAP1 | PARVG | 0.772438 | 5 | 0 | 5 |
| ACAP1 | CORO1A | 0.766494 | 8 | 0 | 7 |
| ACAP1 | TIGIT | 0.761315 | 5 | 0 | 5 |
| ACAP1 | CD3G | 0.755674 | 4 | 0 | 4 |
| ACAP1 | EVL | 0.751027 | 3 | 0 | 3 |
| ACAP1 | ZAP70 | 0.749048 | 7 | 0 | 7 |
| ACAP1 | CD96 | 0.746821 | 6 | 0 | 6 |
| ACAP1 | CD37 | 0.740341 | 8 | 0 | 7 |
| ACAP1 | JAK3 | 0.738382 | 4 | 0 | 4 |
| ACAP1 | TMEM200A | 0.738351 | 3 | 0 | 3 |
| ACAP1 | BCL2L11 | 0.736724 | 4 | 0 | 3 |
| ACAP1 | TCF15 | 0.734542 | 3 | 0 | 3 |
| ACAP1 | PTPRU | 0.731934 | 3 | 0 | 3 |
| ACAP1 | CD3D | 0.729441 | 8 | 0 | 7 |
| ACAP1 | GNGT2 | 0.728735 | 5 | 0 | 5 |
| ACAP1 | C16orf58 | 0.728216 | 3 | 0 | 3 |
| ACAP1 | GZMA | 0.722631 | 5 | 0 | 5 |
| ACAP1 | MAP2K7 | 0.722082 | 4 | 0 | 3 |
For details and further investigation, click here
