| Full name: killer cell lectin like receptor C3 | Alias Symbol: NKG2-E | ||
| Type: protein-coding gene | Cytoband: 12p13.2 | ||
| Entrez ID: 3823 | HGNC ID: HGNC:6376 | Ensembl Gene: ENSG00000205810 | OMIM ID: 602892 |
| Drug and gene relationship at DGIdb | |||
KLRC3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of KLRC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLRC3 | 3823 | 207723_s_at | 0.3222 | 0.6439 | |
| GSE20347 | KLRC3 | 3823 | 207723_s_at | -0.0210 | 0.7478 | |
| GSE23400 | KLRC3 | 3823 | 207723_s_at | -0.0143 | 0.4243 | |
| GSE26886 | KLRC3 | 3823 | 207723_s_at | 0.1781 | 0.1100 | |
| GSE29001 | KLRC3 | 3823 | 207723_s_at | 0.0330 | 0.8107 | |
| GSE38129 | KLRC3 | 3823 | 207723_s_at | 0.0523 | 0.6466 | |
| GSE45670 | KLRC3 | 3823 | 207723_s_at | -0.0681 | 0.5853 | |
| GSE63941 | KLRC3 | 3823 | 207723_s_at | 0.5520 | 0.4330 | |
| GSE77861 | KLRC3 | 3823 | 207723_s_at | -0.0899 | 0.3979 | |
| GSE97050 | KLRC3 | 3823 | A_23_P128281 | 0.1255 | 0.6596 | |
| SRP133303 | KLRC3 | 3823 | RNAseq | -0.1846 | 0.6330 | |
| TCGA | KLRC3 | 3823 | RNAseq | 0.5856 | 0.3716 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLRC3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KLRC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLRC3 | 3823 | 6 | 2 | 22 | |
| GSE20123 | KLRC3 | 3823 | 6 | 2 | 22 | |
| GSE43470 | KLRC3 | 3823 | 9 | 3 | 31 | |
| GSE46452 | KLRC3 | 3823 | 10 | 1 | 48 | |
| GSE47630 | KLRC3 | 3823 | 14 | 2 | 24 | |
| GSE54993 | KLRC3 | 3823 | 1 | 10 | 59 | |
| GSE54994 | KLRC3 | 3823 | 9 | 2 | 42 | |
| GSE60625 | KLRC3 | 3823 | 0 | 1 | 10 | |
| GSE74703 | KLRC3 | 3823 | 9 | 2 | 25 | |
| GSE74704 | KLRC3 | 3823 | 4 | 1 | 15 | |
| TCGA | KLRC3 | 3823 | 39 | 6 | 51 |
Total number of gains: 107; Total number of losses: 32; Total Number of normals: 349.
Somatic mutations of KLRC3:
Generating mutation plots.
Highly correlated genes for KLRC3:
Showing top 20/144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLRC3 | CD36 | 0.780473 | 3 | 0 | 3 |
| KLRC3 | SCML4 | 0.776141 | 3 | 0 | 3 |
| KLRC3 | PARVG | 0.774242 | 3 | 0 | 3 |
| KLRC3 | WDR37 | 0.749221 | 3 | 0 | 3 |
| KLRC3 | BCL2L11 | 0.745368 | 3 | 0 | 3 |
| KLRC3 | PLEKHA4 | 0.737791 | 3 | 0 | 3 |
| KLRC3 | SNX20 | 0.737582 | 3 | 0 | 3 |
| KLRC3 | SPI1 | 0.729664 | 3 | 0 | 3 |
| KLRC3 | ZNF581 | 0.726501 | 3 | 0 | 3 |
| KLRC3 | POLN | 0.718372 | 3 | 0 | 3 |
| KLRC3 | COQ4 | 0.716416 | 3 | 0 | 3 |
| KLRC3 | DENND4B | 0.712949 | 3 | 0 | 3 |
| KLRC3 | ZNF276 | 0.704179 | 3 | 0 | 3 |
| KLRC3 | IL18BP | 0.700507 | 4 | 0 | 3 |
| KLRC3 | RPS19 | 0.69578 | 3 | 0 | 3 |
| KLRC3 | HES7 | 0.693731 | 3 | 0 | 3 |
| KLRC3 | ZMIZ2 | 0.693534 | 3 | 0 | 3 |
| KLRC3 | C8orf44 | 0.693412 | 3 | 0 | 3 |
| KLRC3 | ZNF579 | 0.690813 | 3 | 0 | 3 |
| KLRC3 | TMC5 | 0.690283 | 3 | 0 | 3 |
For details and further investigation, click here
