| Full name: hepatitis A virus cellular receptor 2 | Alias Symbol: Tim-3|TIM3|FLJ14428|TIMD3|CD366 | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 84868 | HGNC ID: HGNC:18437 | Ensembl Gene: ENSG00000135077 | OMIM ID: 606652 |
| Drug and gene relationship at DGIdb | |||
Expression of HAVCR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HAVCR2 | 84868 | 235458_at | 0.6137 | 0.3351 | |
| GSE26886 | HAVCR2 | 84868 | 235458_at | 0.0762 | 0.7937 | |
| GSE45670 | HAVCR2 | 84868 | 235458_at | 0.2481 | 0.4528 | |
| GSE63941 | HAVCR2 | 84868 | 1555628_a_at | -0.0073 | 0.9767 | |
| GSE77861 | HAVCR2 | 84868 | 1555628_a_at | -0.1150 | 0.3453 | |
| GSE97050 | HAVCR2 | 84868 | A_24_P411561 | 0.2508 | 0.2353 | |
| SRP007169 | HAVCR2 | 84868 | RNAseq | 2.2612 | 0.0037 | |
| SRP008496 | HAVCR2 | 84868 | RNAseq | 2.0402 | 0.0001 | |
| SRP064894 | HAVCR2 | 84868 | RNAseq | 1.5186 | 0.0000 | |
| SRP133303 | HAVCR2 | 84868 | RNAseq | 1.1461 | 0.0000 | |
| SRP159526 | HAVCR2 | 84868 | RNAseq | 0.6230 | 0.3549 | |
| SRP193095 | HAVCR2 | 84868 | RNAseq | 0.8394 | 0.0000 | |
| SRP219564 | HAVCR2 | 84868 | RNAseq | 1.9209 | 0.0018 | |
| TCGA | HAVCR2 | 84868 | RNAseq | 0.7502 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by HAVCR2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HAVCR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HAVCR2 | 84868 | 0 | 11 | 19 | |
| GSE20123 | HAVCR2 | 84868 | 0 | 11 | 19 | |
| GSE43470 | HAVCR2 | 84868 | 2 | 11 | 30 | |
| GSE46452 | HAVCR2 | 84868 | 0 | 27 | 32 | |
| GSE47630 | HAVCR2 | 84868 | 0 | 20 | 20 | |
| GSE54993 | HAVCR2 | 84868 | 9 | 1 | 60 | |
| GSE54994 | HAVCR2 | 84868 | 1 | 16 | 36 | |
| GSE60625 | HAVCR2 | 84868 | 0 | 0 | 11 | |
| GSE74703 | HAVCR2 | 84868 | 2 | 8 | 26 | |
| GSE74704 | HAVCR2 | 84868 | 0 | 6 | 14 | |
| TCGA | HAVCR2 | 84868 | 4 | 36 | 56 |
Total number of gains: 18; Total number of losses: 147; Total Number of normals: 323.
Somatic mutations of HAVCR2:
Generating mutation plots.
Highly correlated genes for HAVCR2:
Showing top 20/191 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HAVCR2 | TFEC | 0.826457 | 4 | 0 | 4 |
| HAVCR2 | SNX20 | 0.809929 | 3 | 0 | 3 |
| HAVCR2 | IL18BP | 0.80331 | 3 | 0 | 3 |
| HAVCR2 | TMEM140 | 0.795593 | 3 | 0 | 3 |
| HAVCR2 | IGSF6 | 0.769448 | 5 | 0 | 4 |
| HAVCR2 | SLAMF8 | 0.766084 | 5 | 0 | 5 |
| HAVCR2 | ADAMDEC1 | 0.755823 | 5 | 0 | 5 |
| HAVCR2 | ITGB2 | 0.75233 | 6 | 0 | 5 |
| HAVCR2 | HLA-DMB | 0.751817 | 5 | 0 | 5 |
| HAVCR2 | IL7R | 0.751264 | 3 | 0 | 3 |
| HAVCR2 | JMJD4 | 0.743561 | 3 | 0 | 3 |
| HAVCR2 | NCKAP1L | 0.738893 | 5 | 0 | 4 |
| HAVCR2 | TNFRSF1B | 0.732833 | 5 | 0 | 5 |
| HAVCR2 | MFSD3 | 0.732765 | 3 | 0 | 3 |
| HAVCR2 | RGS19 | 0.73085 | 3 | 0 | 3 |
| HAVCR2 | CCR1 | 0.730155 | 5 | 0 | 5 |
| HAVCR2 | CSNK2B | 0.724219 | 3 | 0 | 3 |
| HAVCR2 | MTCH2 | 0.722293 | 3 | 0 | 3 |
| HAVCR2 | SAMSN1 | 0.721157 | 5 | 0 | 5 |
| HAVCR2 | LANCL2 | 0.71364 | 3 | 0 | 3 |
For details and further investigation, click here
