| Full name: derlin 3 | Alias Symbol: FLJ43842|MGC71803|derlin-3|IZP6 | ||
| Type: protein-coding gene | Cytoband: 22q11.23 | ||
| Entrez ID: 91319 | HGNC ID: HGNC:14236 | Ensembl Gene: ENSG00000099958 | OMIM ID: 610305 |
| Drug and gene relationship at DGIdb | |||
Expression of DERL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DERL3 | 91319 | 229721_x_at | 0.1711 | 0.8667 | |
| GSE26886 | DERL3 | 91319 | 228897_at | 0.2816 | 0.0735 | |
| GSE45670 | DERL3 | 91319 | 228897_at | 0.0906 | 0.5069 | |
| GSE53622 | DERL3 | 91319 | 133880 | 0.0369 | 0.4449 | |
| GSE53624 | DERL3 | 91319 | 133880 | 0.0484 | 0.2774 | |
| GSE63941 | DERL3 | 91319 | 229721_x_at | -0.2841 | 0.0415 | |
| GSE77861 | DERL3 | 91319 | 228897_at | -0.0103 | 0.9702 | |
| GSE97050 | DERL3 | 91319 | A_33_P3724155 | 0.1874 | 0.3186 | |
| SRP064894 | DERL3 | 91319 | RNAseq | 0.1566 | 0.7682 | |
| SRP133303 | DERL3 | 91319 | RNAseq | 0.8114 | 0.1303 | |
| SRP159526 | DERL3 | 91319 | RNAseq | 1.6422 | 0.0625 | |
| SRP219564 | DERL3 | 91319 | RNAseq | 2.9406 | 0.0000 | |
| TCGA | DERL3 | 91319 | RNAseq | -0.2180 | 0.2765 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DERL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DERL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DERL3 | 91319 | 5 | 7 | 18 | |
| GSE20123 | DERL3 | 91319 | 5 | 6 | 19 | |
| GSE43470 | DERL3 | 91319 | 3 | 6 | 34 | |
| GSE46452 | DERL3 | 91319 | 32 | 1 | 26 | |
| GSE47630 | DERL3 | 91319 | 8 | 5 | 27 | |
| GSE54993 | DERL3 | 91319 | 3 | 6 | 61 | |
| GSE54994 | DERL3 | 91319 | 11 | 7 | 35 | |
| GSE60625 | DERL3 | 91319 | 5 | 0 | 6 | |
| GSE74703 | DERL3 | 91319 | 3 | 5 | 28 | |
| GSE74704 | DERL3 | 91319 | 2 | 3 | 15 | |
| TCGA | DERL3 | 91319 | 26 | 15 | 55 |
Total number of gains: 103; Total number of losses: 61; Total Number of normals: 324.
Somatic mutations of DERL3:
Generating mutation plots.
Highly correlated genes for DERL3:
Showing top 20/250 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DERL3 | TEAD2 | 0.803098 | 3 | 0 | 3 |
| DERL3 | MAPRE3 | 0.791162 | 3 | 0 | 3 |
| DERL3 | FAM167B | 0.789391 | 3 | 0 | 3 |
| DERL3 | LGI2 | 0.774154 | 3 | 0 | 3 |
| DERL3 | CCL22 | 0.763898 | 3 | 0 | 3 |
| DERL3 | KCNN1 | 0.762935 | 3 | 0 | 3 |
| DERL3 | SH2B3 | 0.759407 | 3 | 0 | 3 |
| DERL3 | TRIM62 | 0.758325 | 3 | 0 | 3 |
| DERL3 | ITGB2 | 0.756583 | 3 | 0 | 3 |
| DERL3 | DEFB132 | 0.754455 | 3 | 0 | 3 |
| DERL3 | BCAS4 | 0.753577 | 4 | 0 | 4 |
| DERL3 | ATP8B2 | 0.750511 | 4 | 0 | 4 |
| DERL3 | UNC5C | 0.746781 | 3 | 0 | 3 |
| DERL3 | IQCC | 0.745768 | 3 | 0 | 3 |
| DERL3 | PREX1 | 0.740302 | 3 | 0 | 3 |
| DERL3 | HSD11B1 | 0.735226 | 3 | 0 | 3 |
| DERL3 | POU2F2 | 0.733322 | 4 | 0 | 3 |
| DERL3 | NCDN | 0.73332 | 3 | 0 | 3 |
| DERL3 | INSRR | 0.731455 | 3 | 0 | 3 |
| DERL3 | ITM2C | 0.730865 | 3 | 0 | 3 |
For details and further investigation, click here
