| Full name: basic helix-loop-helix family member e41 | Alias Symbol: DEC2|SHARP-1|SHARP1|bHLHe41 | ||
| Type: protein-coding gene | Cytoband: 12p12.1 | ||
| Entrez ID: 79365 | HGNC ID: HGNC:16617 | Ensembl Gene: ENSG00000123095 | OMIM ID: 606200 |
| Drug and gene relationship at DGIdb | |||
BHLHE41 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04710 | Circadian rhythm |
Expression of BHLHE41:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BHLHE41 | 79365 | 221530_s_at | 0.3444 | 0.8008 | |
| GSE20347 | BHLHE41 | 79365 | 221530_s_at | 1.0021 | 0.0055 | |
| GSE23400 | BHLHE41 | 79365 | 221530_s_at | 0.4629 | 0.0030 | |
| GSE26886 | BHLHE41 | 79365 | 221530_s_at | 2.5697 | 0.0000 | |
| GSE29001 | BHLHE41 | 79365 | 221530_s_at | 0.6658 | 0.1763 | |
| GSE38129 | BHLHE41 | 79365 | 221530_s_at | 0.7934 | 0.0193 | |
| GSE45670 | BHLHE41 | 79365 | 221530_s_at | -0.8120 | 0.1131 | |
| GSE53622 | BHLHE41 | 79365 | 104796 | 0.7470 | 0.0001 | |
| GSE53624 | BHLHE41 | 79365 | 104796 | 0.4917 | 0.0061 | |
| GSE63941 | BHLHE41 | 79365 | 221530_s_at | -2.0122 | 0.2067 | |
| GSE77861 | BHLHE41 | 79365 | 231243_s_at | -0.0662 | 0.6219 | |
| GSE97050 | BHLHE41 | 79365 | A_23_P139500 | 0.1026 | 0.8279 | |
| SRP007169 | BHLHE41 | 79365 | RNAseq | 2.0942 | 0.0158 | |
| SRP008496 | BHLHE41 | 79365 | RNAseq | 3.0800 | 0.0003 | |
| SRP064894 | BHLHE41 | 79365 | RNAseq | 1.2755 | 0.0000 | |
| SRP133303 | BHLHE41 | 79365 | RNAseq | 1.2576 | 0.0007 | |
| SRP159526 | BHLHE41 | 79365 | RNAseq | 0.1283 | 0.8498 | |
| SRP193095 | BHLHE41 | 79365 | RNAseq | 0.7335 | 0.0286 | |
| SRP219564 | BHLHE41 | 79365 | RNAseq | 0.8088 | 0.2756 | |
| TCGA | BHLHE41 | 79365 | RNAseq | 0.2414 | 0.1384 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by BHLHE41 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BHLHE41:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BHLHE41 | 79365 | 10 | 1 | 19 | |
| GSE20123 | BHLHE41 | 79365 | 10 | 1 | 19 | |
| GSE43470 | BHLHE41 | 79365 | 9 | 4 | 30 | |
| GSE46452 | BHLHE41 | 79365 | 10 | 1 | 48 | |
| GSE47630 | BHLHE41 | 79365 | 14 | 0 | 26 | |
| GSE54993 | BHLHE41 | 79365 | 0 | 9 | 61 | |
| GSE54994 | BHLHE41 | 79365 | 11 | 2 | 40 | |
| GSE60625 | BHLHE41 | 79365 | 0 | 1 | 10 | |
| GSE74703 | BHLHE41 | 79365 | 9 | 3 | 24 | |
| GSE74704 | BHLHE41 | 79365 | 6 | 1 | 13 | |
| TCGA | BHLHE41 | 79365 | 43 | 5 | 48 |
Total number of gains: 122; Total number of losses: 28; Total Number of normals: 338.
Somatic mutations of BHLHE41:
Generating mutation plots.
Highly correlated genes for BHLHE41:
Showing top 20/752 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BHLHE41 | LONRF3 | 0.78171 | 3 | 0 | 3 |
| BHLHE41 | LRRC14 | 0.775854 | 3 | 0 | 3 |
| BHLHE41 | C20orf96 | 0.766819 | 3 | 0 | 3 |
| BHLHE41 | TAF1L | 0.762722 | 3 | 0 | 3 |
| BHLHE41 | CDK18 | 0.760375 | 3 | 0 | 3 |
| BHLHE41 | RRAS2 | 0.747592 | 3 | 0 | 3 |
| BHLHE41 | DR1 | 0.741945 | 3 | 0 | 3 |
| BHLHE41 | MAPK9 | 0.736571 | 3 | 0 | 3 |
| BHLHE41 | AKR1E2 | 0.724858 | 3 | 0 | 3 |
| BHLHE41 | TCF7L1 | 0.720196 | 5 | 0 | 4 |
| BHLHE41 | ZNF703 | 0.716944 | 3 | 0 | 3 |
| BHLHE41 | NFKB1 | 0.70836 | 3 | 0 | 3 |
| BHLHE41 | RILPL2 | 0.705191 | 5 | 0 | 5 |
| BHLHE41 | IFI27L2 | 0.702418 | 3 | 0 | 3 |
| BHLHE41 | KIAA1324L | 0.694984 | 4 | 0 | 3 |
| BHLHE41 | PRR12 | 0.694949 | 3 | 0 | 3 |
| BHLHE41 | HCFC1R1 | 0.693709 | 5 | 0 | 4 |
| BHLHE41 | DEGS1 | 0.692915 | 3 | 0 | 3 |
| BHLHE41 | CCDC59 | 0.691251 | 3 | 0 | 3 |
| BHLHE41 | MAPK10 | 0.68725 | 3 | 0 | 3 |
For details and further investigation, click here
