| Full name: aldo-keto reductase family 1 member E2 | Alias Symbol: MGC10612 | ||
| Type: protein-coding gene | Cytoband: 10p15.1 | ||
| Entrez ID: 83592 | HGNC ID: HGNC:23437 | Ensembl Gene: ENSG00000165568 | OMIM ID: 617451 |
| Drug and gene relationship at DGIdb | |||
Expression of AKR1E2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKR1E2 | 83592 | 223856_at | -0.0625 | 0.8020 | |
| GSE26886 | AKR1E2 | 83592 | 223856_at | 0.3422 | 0.0030 | |
| GSE45670 | AKR1E2 | 83592 | 223856_at | 0.1175 | 0.4170 | |
| GSE53622 | AKR1E2 | 83592 | 29756 | -0.4983 | 0.0403 | |
| GSE53624 | AKR1E2 | 83592 | 29756 | 0.2878 | 0.1224 | |
| GSE63941 | AKR1E2 | 83592 | 223856_at | 0.6552 | 0.0257 | |
| GSE77861 | AKR1E2 | 83592 | 223856_at | -0.0644 | 0.4740 | |
| GSE97050 | AKR1E2 | 83592 | A_33_P3480561 | -0.1612 | 0.6223 | |
| SRP064894 | AKR1E2 | 83592 | RNAseq | 0.0523 | 0.8787 | |
| SRP133303 | AKR1E2 | 83592 | RNAseq | 0.6918 | 0.0012 | |
| SRP159526 | AKR1E2 | 83592 | RNAseq | 1.4939 | 0.0156 | |
| SRP219564 | AKR1E2 | 83592 | RNAseq | 0.2568 | 0.6017 | |
| TCGA | AKR1E2 | 83592 | RNAseq | 0.4724 | 0.1959 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by AKR1E2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKR1E2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKR1E2 | 83592 | 6 | 7 | 17 | |
| GSE20123 | AKR1E2 | 83592 | 6 | 6 | 18 | |
| GSE43470 | AKR1E2 | 83592 | 4 | 6 | 33 | |
| GSE46452 | AKR1E2 | 83592 | 2 | 14 | 43 | |
| GSE47630 | AKR1E2 | 83592 | 6 | 14 | 20 | |
| GSE54993 | AKR1E2 | 83592 | 11 | 0 | 59 | |
| GSE54994 | AKR1E2 | 83592 | 5 | 10 | 38 | |
| GSE60625 | AKR1E2 | 83592 | 0 | 0 | 11 | |
| GSE74703 | AKR1E2 | 83592 | 2 | 4 | 30 | |
| GSE74704 | AKR1E2 | 83592 | 1 | 5 | 14 | |
| TCGA | AKR1E2 | 83592 | 19 | 25 | 52 |
Total number of gains: 62; Total number of losses: 91; Total Number of normals: 335.
Somatic mutations of AKR1E2:
Generating mutation plots.
Highly correlated genes for AKR1E2:
Showing top 20/96 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKR1E2 | NFIL3 | 0.754391 | 3 | 0 | 3 |
| AKR1E2 | CRYBA1 | 0.736125 | 4 | 0 | 4 |
| AKR1E2 | TIMM9 | 0.729863 | 3 | 0 | 3 |
| AKR1E2 | BHLHE41 | 0.724858 | 3 | 0 | 3 |
| AKR1E2 | ANP32B | 0.723309 | 3 | 0 | 3 |
| AKR1E2 | ING1 | 0.718406 | 3 | 0 | 3 |
| AKR1E2 | SIVA1 | 0.715569 | 3 | 0 | 3 |
| AKR1E2 | WDR93 | 0.714627 | 3 | 0 | 3 |
| AKR1E2 | ZBTB25 | 0.712011 | 3 | 0 | 3 |
| AKR1E2 | ACY1 | 0.706032 | 3 | 0 | 3 |
| AKR1E2 | KCNA2 | 0.705684 | 3 | 0 | 3 |
| AKR1E2 | KCNC4 | 0.699222 | 3 | 0 | 3 |
| AKR1E2 | KIAA1324L | 0.696259 | 3 | 0 | 3 |
| AKR1E2 | EPPK1 | 0.694156 | 3 | 0 | 3 |
| AKR1E2 | ENKUR | 0.693083 | 3 | 0 | 3 |
| AKR1E2 | ARTN | 0.690503 | 3 | 0 | 3 |
| AKR1E2 | BSN | 0.68654 | 3 | 0 | 3 |
| AKR1E2 | TAS2R38 | 0.675926 | 4 | 0 | 3 |
| AKR1E2 | PPP1R35 | 0.67555 | 3 | 0 | 3 |
| AKR1E2 | GLRX5 | 0.668929 | 3 | 0 | 3 |
For details and further investigation, click here
