MAPK10

 

Full name: mitogen-activated protein kinase 10 Alias Symbol: JNK3|p493F12|p54bSAPK
Type: protein-coding gene Cytoband: 4q21.3
Entrez ID: 5602 HGNC ID: HGNC:6872 Ensembl Gene: ENSG00000109339 OMIM ID: 602897
Drug and gene relationship at DGIdb

 

MAPK10 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04024cAMP signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04210Apoptosis
hsa04310Wnt signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05231Choline metabolism in cancer

 

Expression of MAPK10:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAPK10 5602 204813_at -0.1087 0.8440
GSE20347 MAPK10 5602 204813_at 0.5347 0.0097
GSE23400 MAPK10 5602 204813_at 0.1818 0.0023
GSE26886 MAPK10 5602 204813_at 0.9792 0.0039
GSE29001 MAPK10 5602 204813_at 0.4635 0.2049
GSE38129 MAPK10 5602 204813_at 0.1147 0.5724
GSE45670 MAPK10 5602 204813_at 0.0515 0.9065
GSE53622 MAPK10 5602 134817 -0.2449 0.1413
GSE53624 MAPK10 5602 134817 -0.0266 0.8532
GSE63941 MAPK10 5602 204813_at -2.6646 0.0002
GSE77861 MAPK10 5602 204813_at 0.5032 0.2150
GSE97050 MAPK10 5602 A_33_P3254216 -0.6411 0.2018
SRP007169 MAPK10 5602 RNAseq 1.8564 0.0040
SRP008496 MAPK10 5602 RNAseq 1.7073 0.0006
SRP064894 MAPK10 5602 RNAseq -0.1466 0.6401
SRP133303 MAPK10 5602 RNAseq -0.1174 0.6694
SRP159526 MAPK10 5602 RNAseq 0.2635 0.6348
SRP193095 MAPK10 5602 RNAseq 1.2081 0.0000
SRP219564 MAPK10 5602 RNAseq 0.5364 0.4003
TCGA MAPK10 5602 RNAseq -0.2055 0.3611

Upregulated datasets: 3; Downregulated datasets: 1.  

 

Survival by MAPK10 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAPK10:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAPK10 5602 3 12 15
GSE20123 MAPK10 5602 3 12 15
GSE43470 MAPK10 5602 0 13 30
GSE46452 MAPK10 5602 1 36 22
GSE47630 MAPK10 5602 0 20 20
GSE54993 MAPK10 5602 8 0 62
GSE54994 MAPK10 5602 1 9 43
GSE60625 MAPK10 5602 0 0 11
GSE74703 MAPK10 5602 0 11 25
GSE74704 MAPK10 5602 2 7 11
TCGA MAPK10 5602 11 38 47

Total number of gains: 29; Total number of losses: 158; Total Number of normals: 301.  

 

Somatic mutations of MAPK10:

 

Generating mutation plots.

 

Highly correlated genes for MAPK10:

 

Showing top 20/318 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAPK10PIAS20.787455303
MAPK10RPS19BP10.742742303
MAPK10CTDSP10.741352303
MAPK10NUDT160.74131303
MAPK10DAG10.735955303
MAPK10NFYB0.732397303
MAPK10ARRDC40.727544303
MAPK10HMG20A0.71916303
MAPK10MAPKAPK5-AS10.70366303
MAPK10PEAK10.702228303
MAPK10DSEL0.701171303
MAPK10IL330.69651303
MAPK10UBR20.69598303
MAPK10KLHL130.695105505
MAPK10TMEM106B0.69497303
MAPK10CNRIP10.690749303
MAPK10SYNC0.689623303
MAPK10SCARB20.688744303
MAPK10PALLD0.687666303
MAPK10BHLHE410.68725303

For details and further investigation, click here