| Full name: down-regulator of transcription 1 | Alias Symbol: NC2-BETA|NC2B|NCB2 | ||
| Type: protein-coding gene | Cytoband: 1p22.1 | ||
| Entrez ID: 1810 | HGNC ID: HGNC:3017 | Ensembl Gene: ENSG00000117505 | OMIM ID: 601482 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DR1 | 1810 | 209187_at | 0.2018 | 0.6188 | |
| GSE20347 | DR1 | 1810 | 209187_at | -0.1067 | 0.5014 | |
| GSE23400 | DR1 | 1810 | 209188_x_at | 0.2716 | 0.0056 | |
| GSE26886 | DR1 | 1810 | 209187_at | -0.4031 | 0.0448 | |
| GSE29001 | DR1 | 1810 | 209187_at | 0.1690 | 0.6859 | |
| GSE38129 | DR1 | 1810 | 209187_at | 0.0842 | 0.5212 | |
| GSE45670 | DR1 | 1810 | 209187_at | 0.2261 | 0.0985 | |
| GSE63941 | DR1 | 1810 | 209187_at | -0.1313 | 0.8313 | |
| GSE77861 | DR1 | 1810 | 209187_at | -0.4761 | 0.0119 | |
| GSE97050 | DR1 | A_21_P0000189 | 0.0080 | 0.9849 | ||
| SRP007169 | DR1 | 1810 | RNAseq | -0.3671 | 0.3435 | |
| SRP008496 | DR1 | 1810 | RNAseq | -0.3002 | 0.0935 | |
| SRP064894 | DR1 | 1810 | RNAseq | 0.2107 | 0.2302 | |
| SRP133303 | DR1 | 1810 | RNAseq | 0.2584 | 0.0341 | |
| SRP159526 | DR1 | 1810 | RNAseq | -0.3384 | 0.1875 | |
| SRP193095 | DR1 | 1810 | RNAseq | -0.0004 | 0.9978 | |
| SRP219564 | DR1 | 1810 | RNAseq | 0.0650 | 0.8956 | |
| TCGA | DR1 | 1810 | RNAseq | 0.0986 | 0.0375 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DR1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DR1 | 1810 | 0 | 8 | 22 | |
| GSE20123 | DR1 | 1810 | 0 | 8 | 22 | |
| GSE43470 | DR1 | 1810 | 2 | 6 | 35 | |
| GSE46452 | DR1 | 1810 | 1 | 1 | 57 | |
| GSE47630 | DR1 | 1810 | 8 | 5 | 27 | |
| GSE54993 | DR1 | 1810 | 0 | 1 | 69 | |
| GSE54994 | DR1 | 1810 | 6 | 3 | 44 | |
| GSE60625 | DR1 | 1810 | 0 | 0 | 11 | |
| GSE74703 | DR1 | 1810 | 1 | 5 | 30 | |
| GSE74704 | DR1 | 1810 | 0 | 5 | 15 | |
| TCGA | DR1 | 1810 | 6 | 24 | 66 |
Total number of gains: 24; Total number of losses: 66; Total Number of normals: 398.
Somatic mutations of DR1:
Generating mutation plots.
Highly correlated genes for DR1:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DR1 | SGMS1 | 0.767431 | 3 | 0 | 3 |
| DR1 | ZDHHC7 | 0.766365 | 3 | 0 | 3 |
| DR1 | ZNF512 | 0.755177 | 3 | 0 | 3 |
| DR1 | NUB1 | 0.742963 | 3 | 0 | 3 |
| DR1 | ZNF844 | 0.742007 | 3 | 0 | 3 |
| DR1 | BHLHE41 | 0.741945 | 3 | 0 | 3 |
| DR1 | CNOT1 | 0.741644 | 3 | 0 | 3 |
| DR1 | PINK1 | 0.726066 | 3 | 0 | 3 |
| DR1 | SGMS2 | 0.719939 | 3 | 0 | 3 |
| DR1 | MAPK9 | 0.716579 | 3 | 0 | 3 |
| DR1 | FBXL3 | 0.715615 | 3 | 0 | 3 |
| DR1 | PAIP2B | 0.713983 | 3 | 0 | 3 |
| DR1 | MAP2K5 | 0.708221 | 3 | 0 | 3 |
| DR1 | ARF6 | 0.707233 | 3 | 0 | 3 |
| DR1 | ZNF597 | 0.703651 | 3 | 0 | 3 |
| DR1 | EEA1 | 0.702785 | 4 | 0 | 3 |
| DR1 | SEL1L | 0.702237 | 4 | 0 | 3 |
| DR1 | TXLNG | 0.701183 | 3 | 0 | 3 |
| DR1 | SRP9 | 0.698857 | 5 | 0 | 4 |
| DR1 | ASXL2 | 0.698813 | 4 | 0 | 3 |
For details and further investigation, click here
