| Full name: bone morphogenetic protein 6 | Alias Symbol: VGR1 | ||
| Type: protein-coding gene | Cytoband: 6p24.3 | ||
| Entrez ID: 654 | HGNC ID: HGNC:1073 | Ensembl Gene: ENSG00000153162 | OMIM ID: 112266 |
| Drug and gene relationship at DGIdb | |||
BMP6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of BMP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMP6 | 654 | 206176_at | -0.3508 | 0.6462 | |
| GSE20347 | BMP6 | 654 | 206176_at | 0.1903 | 0.0127 | |
| GSE23400 | BMP6 | 654 | 206176_at | -0.2288 | 0.0000 | |
| GSE26886 | BMP6 | 654 | 206176_at | -0.0096 | 0.9647 | |
| GSE29001 | BMP6 | 654 | 206176_at | -0.0252 | 0.8932 | |
| GSE38129 | BMP6 | 654 | 206176_at | 0.2658 | 0.1183 | |
| GSE45670 | BMP6 | 654 | 206176_at | -0.3118 | 0.3503 | |
| GSE53622 | BMP6 | 654 | 13896 | 0.0017 | 0.9927 | |
| GSE53624 | BMP6 | 654 | 13896 | 0.1458 | 0.3909 | |
| GSE63941 | BMP6 | 654 | 206176_at | -4.3236 | 0.0000 | |
| GSE77861 | BMP6 | 654 | 206176_at | 0.1233 | 0.5108 | |
| GSE97050 | BMP6 | 654 | A_23_P19624 | 0.3268 | 0.1849 | |
| SRP007169 | BMP6 | 654 | RNAseq | 3.5912 | 0.0000 | |
| SRP064894 | BMP6 | 654 | RNAseq | 0.1312 | 0.7223 | |
| SRP133303 | BMP6 | 654 | RNAseq | -0.6967 | 0.0058 | |
| SRP159526 | BMP6 | 654 | RNAseq | 0.8727 | 0.1418 | |
| SRP193095 | BMP6 | 654 | RNAseq | 0.0419 | 0.9099 | |
| SRP219564 | BMP6 | 654 | RNAseq | -1.3911 | 0.0018 | |
| TCGA | BMP6 | 654 | RNAseq | -0.2423 | 0.1050 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by BMP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BMP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMP6 | 654 | 3 | 6 | 21 | |
| GSE20123 | BMP6 | 654 | 3 | 6 | 21 | |
| GSE43470 | BMP6 | 654 | 8 | 2 | 33 | |
| GSE46452 | BMP6 | 654 | 1 | 10 | 48 | |
| GSE47630 | BMP6 | 654 | 7 | 8 | 25 | |
| GSE54993 | BMP6 | 654 | 1 | 1 | 68 | |
| GSE54994 | BMP6 | 654 | 10 | 3 | 40 | |
| GSE60625 | BMP6 | 654 | 0 | 1 | 10 | |
| GSE74703 | BMP6 | 654 | 7 | 2 | 27 | |
| GSE74704 | BMP6 | 654 | 2 | 2 | 16 | |
| TCGA | BMP6 | 654 | 15 | 29 | 52 |
Total number of gains: 57; Total number of losses: 70; Total Number of normals: 361.
Somatic mutations of BMP6:
Generating mutation plots.
Highly correlated genes for BMP6:
Showing top 20/418 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMP6 | MED24 | 0.751698 | 3 | 0 | 3 |
| BMP6 | ACSS3 | 0.749946 | 4 | 0 | 4 |
| BMP6 | LMAN1 | 0.71624 | 3 | 0 | 3 |
| BMP6 | SH3PXD2B | 0.705676 | 3 | 0 | 3 |
| BMP6 | ZNF441 | 0.700859 | 3 | 0 | 3 |
| BMP6 | SARDH | 0.700613 | 3 | 0 | 3 |
| BMP6 | ACTA2 | 0.699882 | 3 | 0 | 3 |
| BMP6 | NEDD9 | 0.699617 | 4 | 0 | 4 |
| BMP6 | ZNF610 | 0.699212 | 3 | 0 | 3 |
| BMP6 | SLC1A1 | 0.692589 | 4 | 0 | 3 |
| BMP6 | FLNC | 0.692245 | 3 | 0 | 3 |
| BMP6 | WDFY1 | 0.68868 | 3 | 0 | 3 |
| BMP6 | CYP4V2 | 0.679752 | 3 | 0 | 3 |
| BMP6 | GLIS3 | 0.676466 | 4 | 0 | 3 |
| BMP6 | DZIP1L | 0.672487 | 3 | 0 | 3 |
| BMP6 | ZNF471 | 0.671843 | 4 | 0 | 3 |
| BMP6 | PDE1C | 0.670161 | 4 | 0 | 4 |
| BMP6 | JKAMP | 0.66431 | 3 | 0 | 3 |
| BMP6 | SLC17A3 | 0.660564 | 3 | 0 | 3 |
| BMP6 | IKZF3 | 0.6605 | 4 | 0 | 3 |
For details and further investigation, click here
