ACTA2

 

Full name: actin alpha 2, smooth muscle Alias Symbol: ACTSA
Type: protein-coding gene Cytoband: 10q23.31
Entrez ID: 59 HGNC ID: HGNC:130 Ensembl Gene: ENSG00000107796 OMIM ID: 102620
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ACTA2 involved pathways:

KEGG pathway Description View
hsa04270Vascular smooth muscle contraction

 

Expression of ACTA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ACTA2 59 200974_at -1.2169 0.2459
GSE20347 ACTA2 59 200974_at -0.4698 0.3584
GSE23400 ACTA2 59 200974_at -0.6810 0.0011
GSE26886 ACTA2 59 200974_at 2.2327 0.0046
GSE29001 ACTA2 59 200974_at -0.4960 0.5004
GSE38129 ACTA2 59 200974_at -0.6173 0.2416
GSE45670 ACTA2 59 200974_at -3.1509 0.0000
GSE53622 ACTA2 59 33931 -0.9984 0.0000
GSE53624 ACTA2 59 33931 -0.8783 0.0000
GSE63941 ACTA2 59 200974_at -4.2680 0.0009
GSE77861 ACTA2 59 200974_at 1.4079 0.0392
GSE97050 ACTA2 59 A_23_P150053 -1.1155 0.0828
SRP007169 ACTA2 59 RNAseq 3.8310 0.0000
SRP008496 ACTA2 59 RNAseq 4.5240 0.0000
SRP064894 ACTA2 59 RNAseq 0.0462 0.9191
SRP133303 ACTA2 59 RNAseq -0.7773 0.1551
SRP159526 ACTA2 59 RNAseq -1.1073 0.1124
SRP193095 ACTA2 59 RNAseq 0.6437 0.2146
SRP219564 ACTA2 59 RNAseq -1.0680 0.3452
TCGA ACTA2 59 RNAseq -0.4094 0.0003

Upregulated datasets: 4; Downregulated datasets: 2.  

 

Survival by ACTA2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ACTA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ACTA2 59 2 7 21
GSE20123 ACTA2 59 2 6 22
GSE43470 ACTA2 59 0 8 35
GSE46452 ACTA2 59 0 11 48
GSE47630 ACTA2 59 2 14 24
GSE54993 ACTA2 59 7 0 63
GSE54994 ACTA2 59 1 11 41
GSE60625 ACTA2 59 0 0 11
GSE74703 ACTA2 59 0 6 30
GSE74704 ACTA2 59 1 4 15
TCGA ACTA2 59 7 27 62

Total number of gains: 22; Total number of losses: 94; Total Number of normals: 372.  

 

Somatic mutations of ACTA2:

 

Generating mutation plots.

 

Highly correlated genes for ACTA2:

 

Showing top 20/916 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ACTA2TAGLN0.90022312012
ACTA2ACTBL20.896103303
ACTA2ACTG20.89554313013
ACTA2TPM20.87657713013
ACTA2TPM10.8576213013
ACTA2TMEM470.85384413013
ACTA2MYLK0.85268313013
ACTA2MSRB30.849267707
ACTA2PDLIM30.83515413012
ACTA2CNN10.82453611011
ACTA2LMOD10.82390912012
ACTA2NEXN0.822996909
ACTA2LINC012790.815359404
ACTA2MYH110.80715112012
ACTA2MGP0.80647713013
ACTA2FERMT20.80030513013
ACTA2MRVI10.796007807
ACTA2AOC30.79564413013
ACTA2PLN0.79433113013
ACTA2SYNM0.79260312012

For details and further investigation, click here