FLNC

 

Full name: filamin C Alias Symbol: ABP-280|ABPL
Type: protein-coding gene Cytoband: 7q32.1
Entrez ID: 2318 HGNC ID: HGNC:3756 Ensembl Gene: ENSG00000128591 OMIM ID: 102565
Drug and gene relationship at DGIdb

 

FLNC involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04510Focal adhesion
hsa05132Salmonella infection
hsa05205Proteoglycans in cancer

 

Expression of FLNC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FLNC 2318 207876_s_at -1.6131 0.1341
GSE20347 FLNC 2318 207876_s_at -0.3741 0.0572
GSE23400 FLNC 2318 207876_s_at -0.8217 0.0000
GSE26886 FLNC 2318 207876_s_at 0.5099 0.0195
GSE29001 FLNC 2318 207876_s_at -0.4433 0.3506
GSE38129 FLNC 2318 207876_s_at -0.9524 0.0102
GSE45670 FLNC 2318 207876_s_at -1.3695 0.0000
GSE53622 FLNC 2318 22403 -2.0164 0.0000
GSE53624 FLNC 2318 22403 -1.5211 0.0000
GSE63941 FLNC 2318 207876_s_at -3.4556 0.0009
GSE77861 FLNC 2318 207876_s_at 0.0138 0.9301
GSE97050 FLNC A_21_P0013349 -1.6614 0.0781
SRP007169 FLNC 2318 RNAseq 3.2388 0.0000
SRP008496 FLNC 2318 RNAseq 3.2175 0.0000
SRP064894 FLNC 2318 RNAseq -0.7624 0.1219
SRP133303 FLNC 2318 RNAseq -2.5614 0.0000
SRP159526 FLNC 2318 RNAseq -1.4910 0.0306
SRP193095 FLNC 2318 RNAseq 0.6559 0.2049
SRP219564 FLNC 2318 RNAseq -1.4660 0.2407
TCGA FLNC 2318 RNAseq -0.8670 0.0000

Upregulated datasets: 2; Downregulated datasets: 6.  

 

Survival by FLNC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FLNC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FLNC 2318 8 1 21
GSE20123 FLNC 2318 8 1 21
GSE43470 FLNC 2318 2 3 38
GSE46452 FLNC 2318 7 2 50
GSE47630 FLNC 2318 7 4 29
GSE54993 FLNC 2318 3 5 62
GSE54994 FLNC 2318 8 7 38
GSE60625 FLNC 2318 0 0 11
GSE74703 FLNC 2318 2 3 31
GSE74704 FLNC 2318 4 1 15
TCGA FLNC 2318 28 22 46

Total number of gains: 77; Total number of losses: 49; Total Number of normals: 362.  

 

Somatic mutations of FLNC:

 

Generating mutation plots.

 

Highly correlated genes for FLNC:

 

Showing top 20/1195 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FLNCMYOCD0.858868707
FLNCCNN10.83992510010
FLNCKANK20.83861110010
FLNCCOX7A10.81648611011
FLNCMRVI10.815277808
FLNCMGARP0.815259303
FLNCMAMDC20.811309606
FLNCSYNM0.81033511010
FLNCACTG20.80943712012
FLNCC1QTNF70.809054505
FLNCLMOD10.80506113012
FLNCCYP21A20.800545303
FLNCDIXDC10.7992561009
FLNCLPP0.798552909
FLNCMYL90.79759612012
FLNCGMPR0.797151404
FLNCZNF3470.797113303
FLNCTPM20.79372412011
FLNCCDH190.792755808
FLNCACTBL20.792694303

For details and further investigation, click here